Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4851 KP13_02419 OmpA/MotB domain-containing protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
No map 0.109 0.685 No Hit 0.0% —
4852 KP13_01769 putative ribose ABC transporter substrate-binding protein Experimental + ColabFold model – – No map 0.109 0.484 No Hit 0.0% —
4853 KP13_05606 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.108 No Hit 0.0% —
4854 KP13_03574 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.108 No Hit 0.0% —
4855 KP13_03056 OmpA/MotB domain-containing protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
No map 0.108 0.933 No Hit 0.0% —
4856 KP13_00283 Protein BcsE bcsE AlphaFold DB model + ColabFold model –
GO:0035438Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
No map 0.108 0.602 No Hit 0.0% —
4857 KP13_08327 putative GST-like protein AlphaFold DB model + ColabFold model –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
No map 0.107 0.728 Hit 30.1% 7.22e-06
4858 KP13_01867 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.107 0.266 No Hit 0.0% —
4859 KP13_01598 Serine/threonine-protein phosphatase 1 AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.107 0.272 No Hit 0.0% —
4860 KP13_31584 Type-2 restriction enzyme EcoRII AlphaFold DB model + ColabFold model –
GO:0009307A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme. GO:0009036Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.106 0.771 No Hit 0.0% —
4861 KP13_04252 Putrescine transport system permease protein potH potH AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.106 0.705 No Hit 0.0% —
4862 KP13_03807 Protein-tyrosine-phosphatase in cps region wzb AlphaFold DB model + ColabFold model
3.1.3.48
GO:0004725Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. GO:0006470The process of removing one or more phosphoric residues from a protein.
No map 0.106 0.381 Hit 39.4% 1.46e-06
4863 KP13_03055 putative Type VI secretion system effector AlphaFold DB model + ColabFold model – – No map 0.106 0.175 No Hit 0.0% —
4864 KP13_03051 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.106 0.452 No Hit 0.0% —
4865 KP13_02118 branched-chain amino acid transport ATP-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +710 total
No map 0.106 0.128 Hit 31.9% 1.34e-07
4866 KP13_01061 Type VI secretion system VgrG family protein AlphaFold DB model + ColabFold model – – No map 0.106 0.643 No Hit 0.0% —
4867 KP13_15795 putative diguanylate cyclase AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
No map 0.105 0.986 No Hit 0.0% —
4868 KP13_05162 Membrane-bound lysozyme inhibitor of C-type lysozyme mliC AlphaFold DB model + ColabFold model – – No map 0.105 0.622 No Hit 0.0% —
4869 KP13_04191 3-deoxy-manno-octulosonate cytidylyltransferase kdsB Experimental + ColabFold model
2.7.7.38
GO:0008690Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
No map 0.105 0.415 No Hit 0.0% —
4870 KP13_03536 putative N-acetylmuramoyl-L-alanine amidase amiA amiA AlphaFold DB model + ColabFold model
3.5.1.28
GO:0009253The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0008745Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +14 total
No map 0.105 0.446 No Hit 0.0% —
4871 KP13_01509 Type IV/VI secretion system domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.105 0.83 No Hit 0.0% —
4872 KP13_00711 Nitrite reductase [NAD(P)H] small subunit nirD AlphaFold DB model + ColabFold model
1.7.1.15
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0008942Catalysis of the reaction: NH4+ + 3 NAD(P)+ + 2 H2O = nitrite + 3 NAD(P)H + 5 H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
No map N/A 0.105 No Hit 0.0% —
4873 KP13_00550 Inner membrane protein AlphaFold DB model + ColabFold model – – No map 0.105 0.292 No Hit 0.0% —
4874 KP13_04602 HTH-type transcriptional regulator czcR czcR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
No map 0.104 0.573 No Hit 0.0% —
4875 KP13_04391 HTH-type transcriptional activator AllS allS AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.104 0.358 No Hit 0.0% —
Page of 234 · 5842 total proteins