Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4901 KP13_05206 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.100 0.96 No Hit 0.0% —
4902 KP13_05134 Acid shock protein AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map N/A 0.1 No Hit 0.0% —
4903 KP13_05032 Methylated-DNA--protein-cysteine methyltransferase ogt AlphaFold DB model + ColabFold model
2.1.1.63
GO:0003908Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. +36 total
No map 0.100 0.069 Hit 45.5% 2.50e-21
4904 KP13_04860 hypothetical protein ColabFold model – – No map 0.100 0.156 No Hit 0.0% —
4905 KP13_04760 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.1 No Hit 0.0% —
4906 KP13_02911 Sigma factor-binding protein crl crl AlphaFold DB model + ColabFold model –
GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map N/A 0.1 No Hit 0.0% —
4907 KP13_03416 putative transposase ColabFold model – – No map 0.099 0.599 No Hit 0.0% —
4908 KP13_03104 hypothetical protein ColabFold model – – No map N/A 0.099 No Hit 0.0% —
4909 KP13_01868 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.099 0.311 No Hit 0.0% —
4910 KP13_01420 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.099 0.275 No Hit 0.0% —
4911 KP13_01178 Malonate decarboxylase subunit gamma mdcE AlphaFold DB model + ColabFold model –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
No map 0.099 0.679 No Hit 0.0% —
4912 KP13_02928 putative glutamine amidotransferase AlphaFold DB model + ColabFold model – – No map 0.098 0.303 No Hit 0.0% —
4913 KP13_02677 hypothetical protein ColabFold model – – No map N/A 0.098 No Hit 0.0% —
4914 KP13_00851 Protein iscX iscX AlphaFold DB model + ColabFold model –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
No map N/A 0.098 No Hit 0.0% —
4915 KP13_32240 putative HTH transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.097 0.463 No Hit 0.0% —
4916 KP13_32041 hypothetical protein ColabFold model – – No map 0.097 0.485 No Hit 0.0% —
4917 KP13_06658 Flagellar transcriptional activator FlhD domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.097 0.526 No Hit 0.0% —
4918 KP13_04339 DotU family type VI secretion system protein AlphaFold DB model + ColabFold model – – No map 0.097 0.341 No Hit 0.0% —
4919 KP13_02884 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.097 0.874 No Hit 0.0% —
4920 KP13_02669 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.096 0.676 No Hit 0.0% —
4921 KP13_00605 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.096 No Hit 0.0% —
4922 KP13_31791 RNA polymerase sigma factor RpoD rpoD AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0016987Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
No map 0.095 0.769 No Hit 0.0% —
4923 KP13_04256 Sensory transduction regulator AlphaFold DB model + ColabFold model – – No map 0.095 0.387 No Hit 0.0% —
4924 KP13_04150 Tellurium resistance protein terF AlphaFold DB model + ColabFold model –
GO:0046690Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus.
No map 0.095 0.28 No Hit 0.0% —
4925 KP13_04133 TerY type protein AlphaFold DB model + ColabFold model – – No map 0.095 0.868 No Hit 0.0% —
Page of 234 · 5842 total proteins