Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4876 KP13_04152 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.104 0.822 No Hit 0.0% —
4877 KP13_04066 OsmC-like protein AlphaFold DB model + ColabFold model – – No map N/A 0.104 No Hit 0.0% —
4878 KP13_03232 RNA polymerase sigma-54 factor rpoN Experimental + ColabFold model –
GO:0006352The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place. GO:0016987Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
No map 0.104 0.954 No Hit 0.0% —
4879 KP13_00737 Sulfurtransferase tusD tusD AlphaFold DB model + ColabFold model
2.8.1.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. GO:0016783Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). +36 total
No map 0.104 0.483 No Hit 0.0% —
4880 KP13_00380 LexA repressor lexA AlphaFold DB model + ColabFold model
3.4.21.88
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0009432An error-prone process for repairing damaged microbial DNA. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +58 total
No map 0.104 0.237 No Hit 0.0% —
4881 KP13_32154 ATP-dependent Clp protease proteolytic subunit ClpP clpP AlphaFold DB model + ColabFold model
3.4.21.92
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0004176Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +47 total
No map 0.103 0.576 Hit 56.0% 3.74e-64
4882 KP13_04006 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.103 No Hit 0.0% —
4883 KP13_03015 Universal stress A family protein AlphaFold DB model + ColabFold model – – No map 0.103 0.206 No Hit 0.0% —
4884 KP13_02606 Carbon storage regulator csrA AlphaFold DB model + ColabFold model –
GO:0006109Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. GO:0006402The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. GO:0003723Binding to an RNA molecule or a portion thereof.
No map N/A 0.103 No Hit 0.0% —
4885 KP13_00879 RecT-like protein AlphaFold DB model + ColabFold model –
GO:0006259Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.103 0.633 No Hit 0.0% —
4886 KP13_00767 50S ribosomal protein L30 rpmD AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0015934The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
No map N/A 0.103 No Hit 0.0% —
4887 KP13_31615 Insertion element IS3 family ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.102 0.24 No Hit 0.0% —
4888 KP13_31502 Gamma-glutamyltransferase Experimental + ColabFold model – – No map 0.102 0.734 Hit 30.5% 2.52e-07
4889 KP13_06634 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.102 0.3 No Hit 0.0% —
4890 KP13_03844 Ethanolamine utilization cobalamin adenosyltransferase eutT AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006580The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. +14 total
No map 0.102 0.413 No Hit 0.0% —
4891 KP13_03274 Succinyl-CoA ligase [ADP-forming] subunit alpha sucD AlphaFold DB model + ColabFold model
6.2.1.5
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0009361A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +36 total
No map 0.102 0.867 Hit 68.7% 5.63e-64
4892 KP13_02796 Outer membrane protein tolC tolC AlphaFold DB model + ColabFold model –
GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
No map 0.102 0.397 No Hit 0.0% —
4893 KP13_00828 Nitrogen regulatory protein P-II glnB AlphaFold DB model + ColabFold model –
GO:0030234A molecular function regulator that modulates a catalytic activity. GO:0006808Any process that modulates the frequency, rate or extent of nitrogen utilization. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map N/A 0.102 No Hit 0.0% —
4894 KP13_00819 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.102 0.44 No Hit 0.0% —
4895 KP13_32085 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.101 0.094 No Hit 0.0% —
4896 KP13_32048 hypothetical protein ColabFold model – – No map 0.101 0.019 Hit 62.2% 4.80e-08
4897 KP13_05472 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.101 No Hit 0.0% —
4898 KP13_05111 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.101 No Hit 0.0% —
4899 KP13_03739 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.101 0.14 No Hit 0.0% —
4900 KP13_01050 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.101 0.655 No Hit 0.0% —
Page of 234 · 5842 total proteins