Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4801 KP13_03058 putative Type VI secretion system protein AlphaFold DB model + ColabFold model – – No map 0.119 0.23 No Hit 0.0% —
4802 KP13_01490 Sulphatase-modifying factor domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.119 0.606 Hit 36.9% 1.11e-06
4803 KP13_31905 Putative aliphatic sulfonates transport permease protein ssuC ssuC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.118 0.709 No Hit 0.0% —
4804 KP13_03050 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.118 0.226 No Hit 0.0% —
4805 KP13_02673 hypothetical protein ColabFold model – – No map N/A 0.118 No Hit 0.0% —
4806 KP13_02503 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.118 0.367 No Hit 0.0% —
4807 KP13_01896 8-oxo-dGTP diphosphatase mutT Experimental + ColabFold model
3.6.1.55
GO:0008413Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. +58 total
No map 0.118 0.417 No Hit 0.0% —
4808 KP13_01006 Phosphodiesterase AlphaFold DB model + ColabFold model
3.1.4.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
No map 0.118 0.105 No Hit 0.0% —
4809 KP13_05072 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.117 No Hit 0.0% —
4810 KP13_00316 Nickel-responsive regulator nikR AlphaFold DB model + ColabFold model –
GO:0016151Binding to a nickel (Ni) cation. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0010045Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus. +36 total
No map 0.117 0.272 No Hit 0.0% —
4811 KP13_06694 conjugal transfer TraG-like protein AlphaFold DB model + ColabFold model – – No map 0.116 0.6 No Hit 0.0% —
4812 KP13_04866 Adenylosuccinate lyase purB AlphaFold DB model + ColabFold model
4.3.2.2
GO:0009152The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004018Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. +58 total
No map 0.116 0.248 Hit 23.2% 5.01e-07
4813 KP13_02997 Transcriptional regulator modE modE AlphaFold DB model + ColabFold model –
GO:0030151Binding to a molybdenum ion (Mo). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
No map N/A 0.116 No Hit 0.0% —
4814 KP13_01773 Inner membrane transport permease AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
No map 0.116 0.763 No Hit 0.0% —
4815 KP13_01499 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.116 0.547 No Hit 0.0% —
4816 KP13_00739 Protein tusB tusB AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0002143The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
No map N/A 0.116 No Hit 0.0% —
4817 KP13_04875 Spermidine/putrescine transport system permease protein potC potC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.115 0.482 No Hit 0.0% —
4818 KP13_04084 putative diguanylate cyclase AlphaFold DB model + ColabFold model
2.7.7.65
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +58 total
No map 0.114 0.564 No Hit 0.0% —
4819 KP13_32185 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.113 No Hit 0.0% —
4820 KP13_32014 hypothetical protein ColabFold model – – No map 0.113 0.6 No Hit 0.0% —
4821 KP13_04597 ABC-type transport system, permease component AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.113 0.62 No Hit 0.0% —
4822 KP13_01185 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.113 No Hit 0.0% —
4823 KP13_32220 Osmotically-inducible protein Y osmY AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map N/A 0.112 No Hit 0.0% —
4824 KP13_04433 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.112 0.442 No Hit 0.0% —
4825 KP13_01575 PTS system mannose-specific EIIAB component manX AlphaFold DB model + ColabFold model
2.7.1.191
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +58 total
No map 0.112 0.499 No Hit 0.0% —
Page of 234 · 5842 total proteins