Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4826 KP13_31587 hypothetical protein AlphaFold + ColabFold – – 0.26 No Hit 0.0% —
4827 KP13_06765 hypothetical protein ColabFold – – 0.26 No Hit 0.0% —
4828 KP13_04585 Coenzyme PQQ synthesis protein F pqqF AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0046872Binding to a metal ion. GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. +25 total
0.26 Hit 25.2% 8.10e-22
4829 KP13_01765 putative NAD(P)H dehydrogenase quinone Experimental + ColabFold – – 0.26 Hit 51.9% 1.59e-10
4830 KP13_01041 Phosphohistidine phosphatase sixA sixA AlphaFold + ColabFold
3.1.3.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0101006Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate. GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
0.26 No Hit 0.0% —
4831 KP13_00766 30S ribosomal protein S5 rpsE AlphaFold + ColabFold –
GO:0015935The smaller of the two subunits of a ribosome. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +25 total
0.26 Hit 29.2% 4.60e-08
4832 KP13_05321 Hippurate hydrolase AlphaFold + ColabFold
3.-.-.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. GO:0050118Catalysis of the reaction: H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + acetate. +14 total
0.259 No Hit 0.0% —
4833 KP13_04493 Cystine-binding periplasmic protein AlphaFold + ColabFold – – 0.259 No Hit 0.0% —
4834 KP13_01897 Protein translocase subunit secA secA AlphaFold + ColabFold
7.4.2.8
GO:0006886The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006605The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. +912 total
0.259 No Hit 0.0% —
4835 KP13_31757 hypothetical protein ColabFold – – 0.258 No Hit 0.0% —
4836 KP13_03662 Nitrogen regulatory protein P-II 2 glnK AlphaFold + ColabFold –
GO:0030234A molecular function regulator that modulates a catalytic activity. GO:0006808Any process that modulates the frequency, rate or extent of nitrogen utilization. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.258 No Hit 0.0% —
4837 KP13_02036 LuxR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.258 No Hit 0.0% —
4838 KP13_01850 2'-5'-RNA ligase ligT AlphaFold + ColabFold
3.1.4.58
GO:0008664Catalysis the reaction: a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H+. GO:0004113Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate. GO:0016874Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
0.258 No Hit 0.0% —
4839 KP13_00363 LpxA-like domain-containing transferase AlphaFold + ColabFold – – 0.258 No Hit 0.0% —
4840 KP13_31921 hypothetical protein ColabFold – – 0.257 No Hit 0.0% —
4841 KP13_04338 putative type VI secretion system protein AlphaFold + ColabFold – – 0.257 No Hit 0.0% —
4842 KP13_02913 Xanthine phosphoribosyltransferase gpt AlphaFold + ColabFold
2.4.2.22
GO:0000310Catalysis of the reaction: diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +710 total
0.257 No Hit 0.0% —
4843 KP13_02402 Sulfate adenylyltransferase subunit 1 cysN AlphaFold + ColabFold
2.7.7.4
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate. GO:0006790The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. +47 total
0.257 Hit 37.1% 2.19e-28
4844 KP13_31601 HTH-type transcriptional regulator hdfR hdfR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
0.256 No Hit 0.0% —
4845 KP13_04750 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase AlphaFold + ColabFold
2.4.2.21
GO:0008939Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H+ + nicotinate. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
0.256 No Hit 0.0% —
4846 KP13_03748 putative response regulatory protein AlphaFold + ColabFold –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +14 total
0.256 No Hit 0.0% —
4847 KP13_01504 pyocin domain-containing protein AlphaFold + ColabFold – – 0.256 No Hit 0.0% —
4848 KP13_05078 hypothetical protein ColabFold – – 0.255 No Hit 0.0% —
4849 KP13_02895 Tetratricopeptide repeat-containing protein AlphaFold + ColabFold –
GO:0005515Binding to a protein.
0.255 No Hit 0.0% —
4850 KP13_02446 Xylose isomerase domain-containing protein AlphaFold + ColabFold – – 0.255 No Hit 0.0% —
Page of 234 · 5842 total proteins