Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4976 KP13_02765 Thioredoxin-like fold domain-containing protein AlphaFold + ColabFold – – 0.23 No Hit 0.0% —
4977 KP13_02089 Alkaline phosphatase phoA Experimental + ColabFold
3.1.3.1
GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004035Catalysis of the reaction: a phosphate monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. +14 total
0.23 Hit 30.4% 2.72e-29
4978 KP13_02024 5'-nucleotidase AlphaFold + ColabFold –
GO:0008253Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
0.23 Hit 30.3% 6.95e-16
4979 KP13_00700 hypothetical protein ColabFold – – 0.23 No Hit 0.0% —
4980 KP13_00607 Protein fdhD fdhD AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016783Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.23 No Hit 0.0% —
4981 KP13_06637 hypothetical protein AlphaFold + ColabFold – – 0.229 No Hit 0.0% —
4982 KP13_03202 Beta-glucoside operon antiterminator arbG AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0003723Binding to an RNA molecule or a portion thereof.
0.229 No Hit 0.0% —
4983 KP13_02369 putative aliphatic sulfonates-binding protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.229 No Hit 0.0% —
4984 KP13_02082 hypothetical protein AlphaFold + ColabFold – – 0.229 No Hit 0.0% —
4985 KP13_01324 Metallo-dependent phosphatase AlphaFold + ColabFold –
GO:0004112Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
0.229 No Hit 0.0% —
4986 KP13_31838 putative transposase AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.228 No Hit 0.0% —
4987 KP13_06811 putative transposase AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.228 No Hit 0.0% —
4988 KP13_05969 hypothetical protein AlphaFold + ColabFold – – 0.228 No Hit 0.0% —
4989 KP13_04426 hypothetical protein AlphaFold + ColabFold – – 0.228 No Hit 0.0% —
4990 KP13_04143 hypothetical protein AlphaFold + ColabFold – – 0.228 No Hit 0.0% —
4991 KP13_04007 hypothetical protein AlphaFold + ColabFold – – 0.228 No Hit 0.0% —
4992 KP13_00293 2-dehydro-3-deoxygluconokinase AlphaFold + ColabFold
2.7.1.45
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008673Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H+. +47 total
0.228 No Hit 0.0% —
4993 KP13_32181 HTH-type transcriptional repressor NsrR nsrR AlphaFold + ColabFold –
GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. +36 total
0.227 No Hit 0.0% —
4994 KP13_05658 HNH endonuclease domain-containing protein AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0008270Binding to a zinc ion (Zn). GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
0.227 No Hit 0.0% —
4995 KP13_04631 putative ATP-dependent transporter sufC sufC AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.227 Hit 31.0% 2.68e-10
4996 KP13_04018 hypothetical protein ColabFold – – 0.227 No Hit 0.0% —
4997 KP13_01255 Fructose-1,6-bisphosphatase class 1 fbp AlphaFold + ColabFold
3.1.3.11
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0042578Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. +811 total
0.227 Hit 48.9% 1.20e-31
4998 KP13_01198 hypothetical protein ColabFold – – 0.227 No Hit 0.0% —
4999 KP13_32064 RepFIB replication protein A AlphaFold + ColabFold –
GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0006270The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.
0.226 No Hit 0.0% —
5000 KP13_05218 hypothetical protein AlphaFold + ColabFold – – 0.226 No Hit 0.0% —
Page of 234 · 5842 total proteins