Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5842 / 5842 proteins
No filters or custom sorting applied — click to see defaults

Scoring formula None

Sorted by Druggability (P2Rank preferred) (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5001 KP13_00621 hypothetical protein ColabFold model – – No map 0.086 0.899 No Hit 0.0% —
5002 KP13_32384 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.085 0.722 No Hit 0.0% —
5003 KP13_32118 DNA relaxase mbeA AlphaFold DB model + ColabFold model – – No map 0.085 0.553 No Hit 0.0% —
5004 KP13_06839 integrase AlphaFold DB model + ColabFold model –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.085 0.419 No Hit 0.0% —
5005 KP13_06160 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.085 0.648 No Hit 0.0% —
5006 KP13_05276 Multiple antibiotic resistance protein marA marA AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.085 0.132 No Hit 0.0% —
5007 KP13_05254 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.085 0.712 No Hit 0.0% —
5008 KP13_04379 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.085 0.989 No Hit 0.0% —
5009 KP13_02423 tRNA (guanine-N(1)-)-methyltransferase trmD AlphaFold DB model + ColabFold model
2.1.1.228
GO:0052906Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.085 0.183 No Hit 0.0% —
5010 KP13_02086 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.085 0.748 No Hit 0.0% —
5011 KP13_01919 putative HTH-type transcriptional regulator leuO leuO AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.085 0.674 No Hit 0.0% —
5012 KP13_01673 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.085 0.842 No Hit 0.0% —
5013 KP13_01413 Plasmid stability protein B parB AlphaFold DB model + ColabFold model – – No map 0.085 0.488 No Hit 0.0% —
5014 KP13_00389 Replicative DNA helicase dnaB AlphaFold DB model + ColabFold model
5.6.2.3
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. +710 total
No map 0.085 0.535 No Hit 0.0% —
5015 KP13_32122 insertion sequence IS1 ColabFold model – – No map 0.084 0.507 No Hit 0.0% —
5016 KP13_04178 Beta-lactamase-like protein AlphaFold DB model + ColabFold model
1.6.3.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.084 0.38 No Hit 0.0% —
5017 KP13_03468 PTS family sugar transport protein component IID AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.084 0.855 No Hit 0.0% —
5018 KP13_01891 putative protein transporter AlphaFold DB model + ColabFold model –
GO:0009306The controlled release of proteins from a cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.084 0.892 No Hit 0.0% —
5019 KP13_01063 hypothetical protein ColabFold model – – No map 0.084 0.277 No Hit 0.0% —
5020 KP13_31915 putative Mg2+ transporter CorA family protein AlphaFold DB model + ColabFold model –
GO:0030001The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0046873Enables the transfer of metal ions from one side of a membrane to the other. +69 total
No map 0.083 0.975 No Hit 0.0% —
5021 KP13_06735 conjugal transfer TrbG-like protein trbG AlphaFold DB model + ColabFold model – – No map 0.083 0.286 No Hit 0.0% —
5022 KP13_06666 putative transposase for insertion sequence element IS408 AlphaFold DB model + ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.083 0.796 No Hit 0.0% —
5023 KP13_05140 hypothetical protein ColabFold model – – No map 0.083 0.715 No Hit 0.0% —
5024 KP13_04062 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.083 0.095 No Hit 0.0% —
5025 KP13_03555 Protein cysZ cysZ AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0000103The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. GO:0015116Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. +25 total
No map 0.083 0.568 No Hit 0.0% —
Page of 234 · 5842 total proteins