Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5026 KP13_02126 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
No map 0.083 0.443 No Hit 0.0% —
5027 KP13_01758 HlyD family secretion protein AlphaFold DB model + ColabFold model – – No map 0.083 0.5 No Hit 0.0% —
5028 KP13_01628 hypothetical protein ColabFold model – – No map 0.083 0.488 No Hit 0.0% —
5029 KP13_01054 hypothetical protein ColabFold model – – No map N/A 0.083 No Hit 0.0% —
5030 KP13_31990 transcriptional regulator, AraC family AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.082 0.454 No Hit 0.0% —
5031 KP13_31838 putative transposase AlphaFold DB model + ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.082 0.228 No Hit 0.0% —
5032 KP13_31795 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.082 No Hit 0.0% —
5033 KP13_06811 putative transposase AlphaFold DB model + ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.082 0.228 No Hit 0.0% —
5034 KP13_05549 ABC transporter domain-containing protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.082 0.723 Hit 37.4% 9.64e-20
5035 KP13_02817 transposase for insertion sequence element IS1328 ColabFold model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.082 0.939 No Hit 0.0% —
5036 KP13_00959 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB AlphaFold DB model + ColabFold model
1.17.4.1
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0009263The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0046872Binding to a metal ion. +14 total
No map 0.082 0.425 Hit 24.2% 5.75e-11
5037 KP13_00370 Maltose transport system permease protein malG malG AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.082 0.878 No Hit 0.0% —
5038 KP13_00041 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0008897Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. GO:0000287Binding to a magnesium (Mg) ion.
No map 0.082 0.209 No Hit 0.0% —
5039 KP13_32382 hypothetical protein ColabFold model – – No map N/A 0.081 No Hit 0.0% —
5040 KP13_06674 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.081 0.499 No Hit 0.0% —
5041 KP13_03672 Peptidyl-prolyl cis-trans isomerase D ppiD AlphaFold DB model + ColabFold model –
GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.081 0.513 No Hit 0.0% —
5042 KP13_03341 Rare lipoprotein A rlpA AlphaFold DB model + ColabFold model
4.2.2.-
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0042834Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +47 total
No map 0.081 0.078 No Hit 0.0% —
5043 KP13_02135 Phosphonate transport system permease protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015416Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). GO:0015716The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). +25 total
No map 0.081 0.669 No Hit 0.0% —
5044 KP13_01543 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.081 No Hit 0.0% —
5045 KP13_32023 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.08 No Hit 0.0% —
5046 KP13_05627 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.080 0.294 No Hit 0.0% —
5047 KP13_00878 Prophage CP4-57 regulatory protein AlphaFold DB model + ColabFold model – – No map N/A 0.08 No Hit 0.0% —
5048 KP13_09592 Leucine-specific-binding protein livK AlphaFold DB model + ColabFold model –
GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0015820The directed movement of L-leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.079 0.385 No Hit 0.0% —
5049 KP13_04578 AFG1-family ATPase protein AlphaFold DB model + ColabFold model
1.11.1.6
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. +36 total
No map 0.079 0.535 Hit 46.8% 9.61e-12
5050 KP13_03866 putative lipoprotein AlphaFold DB model + ColabFold model – – No map 0.079 0.364 No Hit 0.0% —
Page of 234 · 5842 total proteins