Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5026 KP13_00082 Acetolactate synthase isozyme 1 small subunit ilvN AlphaFold + ColabFold
2.2.1.6
GO:1990610Binds to and modulates the activity of acetolactate synthase. GO:0009082The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.222 No Hit 0.0% —
5027 KP13_32182 Protein hfq hfq AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.221 No Hit 0.0% —
5028 KP13_04752 HPP family protein AlphaFold + ColabFold – – 0.221 No Hit 0.0% —
5029 KP13_03880 Heat shock protein hspQ hspQ AlphaFold + ColabFold –
GO:0009408Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.221 No Hit 0.0% —
5030 KP13_03713 Cation efflux system protein cusF cusF AlphaFold + ColabFold – – 0.221 No Hit 0.0% —
5031 KP13_03413 putative lipoprotein AlphaFold + ColabFold – – 0.221 No Hit 0.0% —
5032 KP13_03155 putative lipid kinase AlphaFold + ColabFold
2.7.1.-
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0001727Catalysis of the phosphorylation of a simple or complex lipid. +69 total
0.221 Hit 28.2% 8.76e-07
5033 KP13_01433 replication initiation protein RepC repC AlphaFold + ColabFold – – 0.221 No Hit 0.0% —
5034 KP13_00902 hypothetical protein AlphaFold + ColabFold – – 0.221 No Hit 0.0% —
5035 KP13_00866 putative oxidoreductase AlphaFold + ColabFold –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.221 No Hit 0.0% —
5036 KP13_00796 CDP-diacylglycerol--serine O-phosphatidyltransferase pssA AlphaFold + ColabFold –
GO:0032049The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008444Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H+. +25 total
0.221 Hit 27.7% 2.25e-07
5037 KP13_31895 hypothetical protein ColabFold – – 0.22 No Hit 0.0% —
5038 KP13_05632 Transcriptional repressor protein, KorB AlphaFold + ColabFold –
GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0007059The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. GO:0045881Any process that activates or increases the frequency, rate or extent of sporulation.
0.22 No Hit 0.0% —
5039 KP13_04864 tRNA-specific 2-thiouridylase mnmA mnmA AlphaFold + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. GO:0016783Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).
0.22 Hit 54.6% 1.05e-31
5040 KP13_03671 competence protein ComEA-related protein AlphaFold + ColabFold –
GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. +14 total
0.22 Hit 37.5% 4.21e-06
5041 KP13_03010 hypothetical protein ColabFold – – 0.22 No Hit 0.0% —
5042 KP13_02641 hypothetical protein AlphaFold + ColabFold – – 0.22 No Hit 0.0% —
5043 KP13_00616 GCN5-related N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0006048The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. GO:0004343Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+. +25 total
0.22 No Hit 0.0% —
5044 KP13_31857 hypothetical protein ColabFold – – 0.219 No Hit 0.0% —
5045 KP13_31617 Glucosamine--fructose-6-phosphate aminotransferase isomerizing AlphaFold + ColabFold –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0097367Binding to a carbohydrate derivative. GO:0004360Catalysis of the reaction: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. +36 total
0.219 Hit 24.2% 6.96e-09
5046 KP13_04052 hypothetical protein ColabFold – – 0.219 No Hit 0.0% —
5047 KP13_03333 LPS-assembly lipoprotein lptE lptE AlphaFold + ColabFold –
GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +36 total
0.219 No Hit 0.0% —
5048 KP13_02515 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF AlphaFold + ColabFold
4.6.1.12
GO:0016114The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. GO:0008685Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP. GO:0046872Binding to a metal ion. +14 total
0.219 No Hit 0.0% —
5049 KP13_01536 hypothetical protein AlphaFold + ColabFold –
GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water.
0.219 No Hit 0.0% —
5050 KP13_02457 Pili assembly chaperone protein AlphaFold + ColabFold –
GO:0061077OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +14 total
0.218 No Hit 0.0% —
Page of 234 · 5842 total proteins