Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4951 KP13_31775 Acriflavine resistance protein E acrE AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
No map 0.091 0.913 No Hit 0.0% —
4952 KP13_06814 putative transposase AlphaFold DB model + ColabFold model – – No map 0.091 0.074 No Hit 0.0% —
4953 KP13_06681 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.091 0.998 No Hit 0.0% —
4954 KP13_04125 putative transposase AlphaFold DB model + ColabFold model – – No map 0.091 0.074 No Hit 0.0% —
4955 KP13_04120 putative transposase AlphaFold DB model + ColabFold model – – No map 0.091 0.074 No Hit 0.0% —
4956 KP13_03959 putative transposase AlphaFold DB model + ColabFold model – – No map 0.091 0.074 No Hit 0.0% —
4957 KP13_03730 putative transposase AlphaFold DB model + ColabFold model – – No map 0.091 0.074 No Hit 0.0% —
4958 KP13_02504 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.091 0.559 No Hit 0.0% —
4959 KP13_02430 putative inorganic polyphosphate/ATP-NAD kinase ppnK AlphaFold DB model + ColabFold model
2.7.1.23
GO:0003951Catalysis of the reaction: ATP + NAD+ = ADP + H+ + NADP+. GO:0006741The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide phosphate (NADP+), a coenzyme that interconverts with its reduced form, NADPH, in many redox and biosynthetic reactions. GO:0019674The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. +47 total
No map 0.091 0.431 Hit 27.6% 8.65e-19
4960 KP13_02196 Thiol:disulfide interchange protein DsbC dsbC AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.091 0.238 No Hit 0.0% —
4961 KP13_02155 putative transposase AlphaFold DB model + ColabFold model – – No map 0.091 0.074 No Hit 0.0% —
4962 KP13_01839 General secretion pathway protein F pulF AlphaFold DB model + ColabFold model –
GO:0009306The controlled release of proteins from a cell. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
No map 0.091 0.906 No Hit 0.0% —
4963 KP13_01585 putative transposase AlphaFold DB model + ColabFold model – – No map 0.091 0.074 No Hit 0.0% —
4964 KP13_01100 Translation initiation factor IF-2 infB AlphaFold DB model + ColabFold model –
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate. GO:0003743Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. +36 total
No map 0.091 0.644 Hit 41.5% 5.97e-126
4965 KP13_01069 putative transposase AlphaFold DB model + ColabFold model – – No map 0.091 0.074 No Hit 0.0% —
4966 KP13_00818 putative ferredoxin-like protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion.
No map 0.091 0.454 No Hit 0.0% —
4967 KP13_32141 hypothetical protein ColabFold model – – No map N/A 0.09 No Hit 0.0% —
4968 KP13_31482 Stationary-phase-induced ribosome-associated protein sra AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
No map N/A 0.09 No Hit 0.0% —
4969 KP13_07007 hypothetical protein ColabFold model – – No map 0.090 0.801 No Hit 0.0% —
4970 KP13_02455 LuxR family transcriptional regulatory protein AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.090 0.566 No Hit 0.0% —
4971 KP13_01929 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
No map 0.090 0.655 No Hit 0.0% —
4972 KP13_00746 Bacterioferritin bfr AlphaFold DB model + ColabFold model
1.16.3.1
GO:0008199Binding to a ferric iron ion, Fe(III). GO:0006879A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell. GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +47 total
No map 0.090 0.331 No Hit 0.0% —
4973 KP13_00128 FMN-binding domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.090 0.56 No Hit 0.0% —
4974 KP13_32101 conjugal transfer TraH-like (IncFII R100) protein AlphaFold DB model + ColabFold model – – No map 0.089 0.356 No Hit 0.0% —
4975 KP13_05632 Transcriptional repressor protein, KorB AlphaFold DB model + ColabFold model –
GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0007059The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. GO:0045881Any process that activates or increases the frequency, rate or extent of sporulation.
No map 0.089 0.22 No Hit 0.0% —
Page of 234 · 5842 total proteins