Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5051 KP13_03543 Sulfate transport system permease protein cysW cysW AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015419Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
No map 0.079 0.371 No Hit 0.0% —
5052 KP13_03280 Succinate dehydrogenase hydrophobic membrane anchor subunit sdhD AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0000104Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor. +58 total
No map 0.079 0.529 No Hit 0.0% —
5053 KP13_01661 Inner membrane amino-acid ABC transporter permease protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +36 total
No map 0.079 0.866 No Hit 0.0% —
5054 KP13_00802 Autonomous glycyl radical cofactor grcA AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008861Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate.
No map N/A 0.079 No Hit 0.0% —
5055 KP13_32214 putative lipoprotein AlphaFold DB model + ColabFold model – – No map 0.078 0.568 No Hit 0.0% —
5056 KP13_31955 putative glutathione peroxidase AlphaFold DB model + ColabFold model –
GO:0004602Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. GO:0006979Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
No map 0.078 0.389 Hit 53.9% 4.11e-18
5057 KP13_31923 Putative ABC transporter arginine-binding protein 2 artI AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0071705The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +25 total
No map 0.078 0.07 No Hit 0.0% —
5058 KP13_04026 Gp7 phage protein AlphaFold DB model + ColabFold model – – No map 0.078 0.088 No Hit 0.0% —
5059 KP13_03634 Maltose O-acetyltransferase maa AlphaFold DB model + ColabFold model –
GO:0016407Catalysis of the transfer of an acetyl group to an acceptor molecule. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.078 0.123 No Hit 0.0% —
5060 KP13_03337 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0043023Binding to a large ribosomal subunit. GO:0042256The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol. +25 total
No map 0.078 0.583 Hit 35.6% 3.22e-15
5061 KP13_03325 Glutamate/aspartate periplasmic-binding protein gltI AlphaFold DB model + ColabFold model –
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.078 0.912 No Hit 0.0% —
5062 KP13_01473 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.078 No Hit 0.0% —
5063 KP13_00584 Transcriptional regulatory protein cpxR cpxR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +58 total
No map 0.078 0.865 No Hit 0.0% —
5064 KP13_00513 Fumarate reductase iron-sulfur subunit frdB AlphaFold DB model + ColabFold model
1.3.5.1
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. +811 total
No map 0.078 0.508 Hit 37.2% 8.45e-11
5065 KP13_01481 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.077 0.525 No Hit 0.0% —
5066 KP13_00918 hypothetical protein ColabFold model – – No map 0.077 0.339 No Hit 0.0% —
5067 KP13_05573 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.076 0.296 No Hit 0.0% —
5068 KP13_04332 Inner membrane transport permease AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +14 total
No map 0.076 0.787 No Hit 0.0% —
5069 KP13_02303 putative propanediol utilization proteni AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map N/A 0.076 No Hit 0.0% —
5070 KP13_31558 Protein bax bax AlphaFold DB model + ColabFold model –
GO:0004040Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH4+.
No map 0.075 0.637 No Hit 0.0% —
5071 KP13_31497 Orotate phosphoribosyltransferase pyrE AlphaFold DB model + ColabFold model
2.4.2.10
GO:0004588Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. GO:0006221The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
No map 0.075 0.116 Hit 31.2% 3.16e-08
5072 KP13_06812 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.075 0.81 No Hit 0.0% —
5073 KP13_04168 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.075 0.81 No Hit 0.0% —
5074 KP13_04098 FMN-dependent NADH-azoreductase 4 azoR4 Experimental + ColabFold model –
GO:0016655Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
No map 0.075 0.25 No Hit 0.0% —
5075 KP13_04055 RNA-directed DNA polymerase AlphaFold DB model + ColabFold model
2.7.7.49
GO:0006278A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand. GO:0003964Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. GO:0003723Binding to an RNA molecule or a portion thereof. +25 total
No map 0.075 0.506 No Hit 0.0% —
Page of 234 · 5842 total proteins