Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5051 KP13_01221 hypothetical protein AlphaFold + ColabFold – – 0.218 No Hit 0.0% —
5052 KP13_31922 EvpB family type VI secretion protein AlphaFold + ColabFold – – 0.217 No Hit 0.0% —
5053 KP13_31515 Long-chain-fatty-acid--CoA ligase fadD AlphaFold + ColabFold – – 0.217 Hit 42.0% 2.88e-07
5054 KP13_05407 putative ABC transporter ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.217 Hit 42.9% 3.56e-06
5055 KP13_04921 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH AlphaFold + ColabFold
2.3.1.180
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. +25 total
0.217 No Hit 0.0% —
5056 KP13_02685 hypothetical protein AlphaFold + ColabFold – – 0.217 No Hit 0.0% —
5057 KP13_02438 Flavin reductase domain-containing protein AlphaFold + ColabFold –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016646Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.
0.217 No Hit 0.0% —
5058 KP13_01873 Aconitate hydratase acnB AlphaFold + ColabFold
4.2.1.3 4.2.1.99
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +58 total
0.217 No Hit 0.0% —
5059 KP13_01487 Sulphatase-modifying factor domain-containing protein AlphaFold + ColabFold
2.7.11.1
GO:0120147Catalysis of the reaction: A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O. GO:0004674Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
0.217 Hit 36.1% 4.36e-06
5060 KP13_01333 hypothetical protein AlphaFold + ColabFold – – 0.217 No Hit 0.0% —
5061 KP13_04553 hypothetical protein AlphaFold + ColabFold – – 0.216 No Hit 0.0% —
5062 KP13_04418 hypothetical protein AlphaFold + ColabFold – – 0.216 No Hit 0.0% —
5063 KP13_04144 Tellurium resistance protein terZ terZ AlphaFold + ColabFold –
GO:0046690Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus.
0.216 No Hit 0.0% —
5064 KP13_01120 Sugar fermentation stimulation protein B sfsB AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.216 No Hit 0.0% —
5065 KP13_00816 Pyridoxine 5'-phosphate synthase pdxJ AlphaFold + ColabFold
2.6.99.2
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008615The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. GO:0033856Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = 2 H2O + H+ + phosphate + pyridoxine 5'-phosphate. +14 total
0.216 No Hit 0.0% —
5066 KP13_00757 50S ribosomal protein L29 rpmC AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
0.216 No Hit 0.0% —
5067 KP13_32381 2Fe-2S ferredoxin-type domain-containing protein AlphaFold + ColabFold –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
0.215 No Hit 0.0% —
5068 KP13_31611 Propanediol utilization protein pduB pduB AlphaFold + ColabFold –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy. GO:0005198The action of a molecule that contributes to the structural integrity of a complex.
0.215 No Hit 0.0% —
5069 KP13_03347 Sec-independent protein translocase protein tatE tatE AlphaFold + ColabFold –
GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043953The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex. +25 total
0.215 No Hit 0.0% —
5070 KP13_02366 hypothetical protein AlphaFold + ColabFold – – 0.215 No Hit 0.0% —
5071 KP13_04948 hypothetical protein AlphaFold + ColabFold – – 0.214 No Hit 0.0% —
5072 KP13_02216 MSF superfamily transporter AlphaFold + ColabFold – – 0.214 No Hit 0.0% —
5073 KP13_02201 putative lipoprotein AlphaFold + ColabFold –
GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.214 No Hit 0.0% —
5074 KP13_00543 hypothetical protein ColabFold – – 0.214 No Hit 0.0% —
5075 KP13_04029 Gp10 phage protein AlphaFold + ColabFold – – 0.213 No Hit 0.0% —
Page of 234 · 5842 total proteins