Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
551 KP13_31524 2,3-dihydroxyphenylpropionate/2, 3-dihydroxicinnamic acid 1,2-dioxygenase mhpB AlphaFold + ColabFold
1.13.11.16
GO:0019439OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. GO:0006725OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. GO:0047070Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate. +47 total
0.928 No Hit 0.0% —
552 KP13_05359 Tryptophan synthase alpha chain trpA AlphaFold + ColabFold –
GO:0004834Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. GO:0006568The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
0.928 No Hit 0.0% —
553 KP13_05119 putative glyoxalase AlphaFold + ColabFold – – 0.928 No Hit 0.0% —
554 KP13_04911 PTS system glucose-specific EIICB component ptsG AlphaFold + ColabFold
2.7.1.199
GO:1904659The process in which D-glucose is transported across a membrane. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005355OBSOLETE. Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. +69 total
0.928 No Hit 0.0% —
555 KP13_01935 Thiamine-binding periplasmic protein thiB AlphaFold + ColabFold –
GO:0030975Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0015888The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.928 No Hit 0.0% —
556 KP13_01697 Protein wzxE wzxE AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria.
0.928 No Hit 0.0% —
557 KP13_00657 Quercetin 2,3-dioxygenase AlphaFold + ColabFold – – 0.928 Hit 31.8% 2.80e-07
558 KP13_05460 Protein mpaA mpaA AlphaFold + ColabFold
3.4.17.-
GO:0008270Binding to a zinc ion (Zn). GO:0009253The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +69 total
0.927 No Hit 0.0% —
559 KP13_03482 Putative nucleoside transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005337Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +14 total
0.927 No Hit 0.0% —
560 KP13_03142 DNA-3-methyladenine glycosylase 2 alkA AlphaFold + ColabFold
3.2.2.21
GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. +811 total
0.927 No Hit 0.0% —
561 KP13_02921 Na(+)-translocating NADH-quinone reductase subunit E nqrE AlphaFold + ColabFold
7.2.1.1
GO:0016655Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022904A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. +47 total
0.927 No Hit 0.0% —
562 KP13_05288 hypothetical protein ColabFold – – 0.926 No Hit 0.0% —
563 KP13_02942 putative MFS general substrate transporter AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.926 No Hit 0.0% —
564 KP13_02901 Dihydrolipoamide dehydrogenase acoD AlphaFold + ColabFold
1.8.1.4
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016668Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. +47 total
0.926 Hit 63.2% 2.81e-16
565 KP13_02331 Protein cbiG cbiG AlphaFold + ColabFold –
GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
0.926 No Hit 0.0% —
566 KP13_01757 putative membrane protein AlphaFold + ColabFold – – 0.926 No Hit 0.0% —
567 KP13_00982 NADH-quinone oxidoreductase subunit M nuoM AlphaFold + ColabFold –
GO:0042773The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0012505A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. +47 total
0.926 Hit 32.4% 2.84e-44
568 KP13_04681 6-phosphofructokinase isozyme 2 pfkB AlphaFold + ColabFold –
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +36 total
0.925 No Hit 0.0% —
569 KP13_03980 F-type conjugal transfer mating pair stabilization protein TraN AlphaFold + ColabFold – – 0.925 No Hit 0.0% —
570 KP13_03478 putative periplasmic binding protein/LacI transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.925 No Hit 0.0% —
571 KP13_02387 Nucleoside triphosphate pyrophosphohydrolase mazG AlphaFold + ColabFold
3.6.1.8
GO:0047693Catalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate. GO:0046061The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate). GO:0006203The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate. +58 total
0.925 No Hit 0.0% —
572 KP13_00471 putative biofilm PGA synthesis protein pgaD pgaD AlphaFold + ColabFold –
GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.925 No Hit 0.0% —
573 KP13_31496 Adenine phosphoribosyltransferase apt AlphaFold + ColabFold
2.4.2.7
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003999Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. GO:0006168Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis. +36 total
0.924 Hit 44.7% 2.96e-33
574 KP13_04732 hypothetical protein AlphaFold + ColabFold – – 0.924 No Hit 0.0% —
575 KP13_04507 Ferric transport system permease protein fbpB fbpB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.924 No Hit 0.0% —
Page of 234 · 5842 total proteins