Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
551 KP13_01038 Chorismate synthase aroC AlphaFold DB model + ColabFold model
4.2.3.5
GO:0004107Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. GO:0009073The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
No map 0.946 0.319 No Hit 0.0% —
552 KP13_00395 UvrABC system protein A uvrA AlphaFold DB model + ColabFold model –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006289A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +69 total
No map 0.946 0.839 Hit 32.9% 1.45e-06
553 KP13_08655 tRNA-dihydrouridine synthase A dusA AlphaFold DB model + ColabFold model
1.3.1.91
GO:0017150Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H. GO:0002943The process whereby a uridine in a transfer RNA is converted to dihydrouridine. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. +58 total
No map 0.945 0.416 Hit 32.1% 5.81e-08
554 KP13_04194 Tetraacyldisaccharide 4'-kinase lpxK AlphaFold DB model + ColabFold model
2.7.1.130
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009029Catalysis of the reaction: a lipid A disaccharide + ATP = a lipid IVA + ADP + H+. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. +25 total
No map 0.945 0.786 No Hit 0.0% —
555 KP13_02883 putative glutathione S-transferase AlphaFold DB model + ColabFold model –
GO:0004364Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.945 0.765 No Hit 0.0% —
556 KP13_02353 L-fuculokinase fucK AlphaFold DB model + ColabFold model
2.7.1.51
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0008737Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H+. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +36 total
No map 0.945 0.236 Hit 22.7% 2.22e-07
557 KP13_00961 Glycerol-3-phosphate transporter glpT AlphaFold DB model + ColabFold model –
GO:0015794The process in which glycerol-3-phosphate is transported across a membrane. Glycerol-3-phosphate is a phosphoric monoester of glycerol. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0015169Enables the transfer of glycerol-3-phosphate from one side of a membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol. +58 total
No map 0.945 0.564 Hit 29.5% 1.84e-33
558 KP13_00837 putative 3-phenylpropionic acid transporter hcaT AlphaFold DB model + ColabFold model – – No map 0.945 0.87 No Hit 0.0% —
559 KP13_31581 Mercuric resistance protein merC merC AlphaFold DB model + ColabFold model –
GO:0015097Enables the transfer of mercury (Hg2+) ions from one side of a membrane to the other. GO:0015694The directed movement of mercury (Hg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map N/A 0.944 No Hit 0.0% —
560 KP13_05244 putative sugar transport protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.944 0.855 No Hit 0.0% —
561 KP13_05184 putative hydrolase AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.944 0.495 No Hit 0.0% —
562 KP13_04904 NADH dehydrogenase ndh AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003955Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol. GO:0019646A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient.
No map 0.944 0.818 No Hit 0.0% —
563 KP13_04638 Multidrug resistance protein mdtB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.944 0.718 No Hit 0.0% —
564 KP13_04141 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.944 0.613 No Hit 0.0% —
565 KP13_03813 Beta-glucoside kinase bglK AlphaFold DB model + ColabFold model –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
No map 0.944 0.425 Hit 26.3% 6.39e-16
566 KP13_03696 4-hydroxybenzoate transporter AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.944 0.417 Hit 33.3% 5.89e-09
567 KP13_03515 Fructokinase scrK AlphaFold DB model + ColabFold model –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008865Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate. +14 total
No map 0.944 0.459 Hit 28.9% 9.43e-17
568 KP13_02175 Protein visC visC AlphaFold DB model + ColabFold model –
GO:0016709Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +58 total
No map 0.944 0.908 Hit 37.0% 2.96e-21
569 KP13_02153 Fimbrial biogenesis outer membrane usher protein AlphaFold DB model + ColabFold model –
GO:0005515Binding to a protein. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473A porin that acts in the assembly of fimbria together with fimbrial chaperone. +25 total
No map 0.944 0.519 No Hit 0.0% —
570 KP13_01302 GCN5-related N-acetyltransferase AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.
No map 0.944 0.527 Hit 40.0% 3.29e-10
571 KP13_01188 Thiamine biosynthesis lipoprotein apbE AlphaFold DB model + ColabFold model
2.7.1.180
GO:0017013The addition of a flavin group to a protein amino acid. GO:0046872Binding to a metal ion. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
No map 0.944 0.381 No Hit 0.0% —
572 KP13_31609 Thiamine-phosphate synthase thiE AlphaFold DB model + ColabFold model
2.5.1.3
GO:0009228The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0004789Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H+ = diphosphate + thiamine phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.943 0.713 No Hit 0.0% —
573 KP13_31575 Plasmid segregation protein parM AlphaFold DB model + ColabFold model – – No map 0.943 0.695 No Hit 0.0% —
574 KP13_26403 Phosphatidylglycerophosphatase B pgpB AlphaFold DB model + ColabFold model
3.6.1.27
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0050380Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate.
No map 0.943 0.981 No Hit 0.0% —
575 KP13_04157 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.943 0.016 No Hit 0.0% —
Page of 234 · 5842 total proteins