Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5376 KP13_01017 Lysine-arginine-ornithine-binding periplasmic protein argT AlphaFold DB model + ColabFold model –
GO:0071705The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.034 0.166 No Hit 0.0% —
5377 KP13_00572 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.034 No Hit 0.0% —
5378 KP13_05616 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.033 0.694 No Hit 0.0% —
5379 KP13_05183 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.033 0.397 No Hit 0.0% —
5380 KP13_05021 Inner membrane protein AlphaFold DB model + ColabFold model – – No map 0.033 0.849 No Hit 0.0% —
5381 KP13_04322 putative transketolase family protein AlphaFold DB model + ColabFold model
2.2.1.7
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008661Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H+ + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2.
No map 0.033 0.132 Hit 35.3% 9.40e-24
5382 KP13_03299 KDP operon transcriptional regulatory protein kdpE kdpE AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +69 total
No map 0.033 0.556 No Hit 0.0% —
5383 KP13_02492 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, HpaG1subunit AlphaFold DB model + ColabFold model –
GO:0018800Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2. GO:0008704Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +14 total
No map 0.033 0.881 Hit 30.5% 4.86e-16
5384 KP13_01702 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.033 No Hit 0.0% —
5385 KP13_00922 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.033 0.729 No Hit 0.0% —
5386 KP13_00502 FimC-like chaperone protein AlphaFold DB model + ColabFold model –
GO:0061077OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +14 total
No map 0.033 0.356 No Hit 0.0% —
5387 KP13_00482 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.033 0.2 No Hit 0.0% —
5388 KP13_05655 Pullulanase secretion protein pulS pulS Experimental + AlphaFold DB model + ColabFold model –
GO:0006886The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
No map 0.032 0.542 No Hit 0.0% —
5389 KP13_05458 Thiol peroxidase tpx AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008379Catalysis of the reaction: [thioredoxin]-dithiol + H2O2 = [thioredoxin]-disulfide + H2O. GO:0016684Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. +14 total
No map 0.032 0.571 No Hit 0.0% —
5390 KP13_03419 Transketolase domain-containing protein AlphaFold DB model + ColabFold model
2.2.1.7
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008661Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H+ + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2.
No map 0.032 0.545 Hit 28.3% 9.52e-18
5391 KP13_03358 Thiol:disulfide interchange protein dsbG dsbG AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.032 0.101 No Hit 0.0% —
5392 KP13_02152 Pili assembly chaperone AlphaFold DB model + ColabFold model –
GO:0061077OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +14 total
No map 0.032 0.324 No Hit 0.0% —
5393 KP13_01621 Holliday junction ATP-dependent DNA helicase ruvA ruvA AlphaFold DB model + ColabFold model –
GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0009379A DNA helicase complex found at Holliday junctions where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA. +811 total
No map 0.032 0.515 No Hit 0.0% —
5394 KP13_01397 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.032 No Hit 0.0% —
5395 KP13_01269 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.032 0.808 No Hit 0.0% —
5396 KP13_01102 Ribosome maturation factor rimP rimP AlphaFold DB model + ColabFold model –
GO:0042274A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
No map 0.032 0.317 No Hit 0.0% —
5397 KP13_00751 50S ribosomal protein L23 rplW AlphaFold DB model + ColabFold model –
GO:0019843Binding to a ribosomal RNA. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +14 total
No map 0.032 0.398 Hit 35.9% 4.60e-06
5398 KP13_00699 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.032 0.715 No Hit 0.0% —
5399 KP13_32436 Transcriptional repressor protein KorC AlphaFold DB model + ColabFold model – – No map 0.031 0.552 No Hit 0.0% —
5400 KP13_31806 Type VI secretion system protein AlphaFold DB model + ColabFold model – – No map 0.031 0.74 No Hit 0.0% —
Page of 234 · 5842 total proteins