Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5351 KP13_00412 putative spermidine/putrescine ABC transporter permease protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.036 0.658 No Hit 0.0% —
5352 KP13_00034 Phosphate transport system protein phoU phoU AlphaFold DB model + ColabFold model –
GO:0030643A homeostatic process involved in the maintenance of a steady state level of phosphate ions within a cell. GO:0045936Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.036 0.583 No Hit 0.0% —
5353 KP13_09841 ADP compounds hydrolase nudE nudE AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019144Catalysis of the reaction: ADP-sugar + H2O = AMP + alpha-D-aldose 1-phosphate. +25 total
No map 0.035 0.306 Hit 29.9% 9.50e-09
5354 KP13_06659 Flagellar transcriptional activator FlhC AlphaFold DB model + ColabFold model –
GO:1902208Any process that modulates the frequency, rate or extent of bacterial-type flagellum assembly. GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
No map 0.035 0.892 No Hit 0.0% —
5355 KP13_06618 hypothetical protein ColabFold model – – No map 0.035 0.526 No Hit 0.0% —
5356 KP13_05761 hypothetical protein ColabFold model – – No map 0.035 0.352 No Hit 0.0% —
5357 KP13_04895 Lipoprotein-releasing system transmembrane protein lolC lolC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042953The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0098797Any protein complex that is part of the plasma membrane. +14 total
No map 0.035 0.296 No Hit 0.0% —
5358 KP13_03870 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.035 0.142 No Hit 0.0% —
5359 KP13_03459 putative lipoprotein AlphaFold DB model + ColabFold model – – No map 0.035 0.587 No Hit 0.0% —
5360 KP13_03376 putative purine catabolism regulatory protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.035 0.444 No Hit 0.0% —
5361 KP13_01426 Uroporphyrin-III C/tetrapyrrole ColabFold model –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule.
No map 0.035 0.249 No Hit 0.0% —
5362 KP13_01410 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.035 0.03 No Hit 0.0% —
5363 KP13_01377 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.035 0.35 No Hit 0.0% —
5364 KP13_01289 Aspartate carbamoyltransferase regulatory chain pyrI AlphaFold DB model + ColabFold model –
GO:0006207The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. GO:0009347A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides.
No map 0.035 0.787 No Hit 0.0% —
5365 KP13_01180 Phosphoribosyl-dephospho-CoA transferase mdcG ColabFold model –
GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
No map 0.035 0.356 No Hit 0.0% —
5366 KP13_01062 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.035 No Hit 0.0% —
5367 KP13_00900 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.035 No Hit 0.0% —
5368 KP13_00571 Met repressor metJ AlphaFold DB model + ColabFold model –
GO:0006555The chemical reactions and pathways involving L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +47 total
No map 0.035 0.264 No Hit 0.0% —
5369 KP13_32064 RepFIB replication protein A AlphaFold DB model + ColabFold model –
GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0006270The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.
No map 0.034 0.226 No Hit 0.0% —
5370 KP13_13049 Ferritin-like protein AlphaFold DB model + ColabFold model –
GO:0008199Binding to a ferric iron ion, Fe(III).
No map 0.034 0.394 No Hit 0.0% —
5371 KP13_05068 DsbA-like thioredoxin domain-containing protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.034 0.836 No Hit 0.0% —
5372 KP13_04345 putative lipoprotein AlphaFold DB model + ColabFold model – – No map 0.034 0.335 No Hit 0.0% —
5373 KP13_03566 hypothetical protein ColabFold model – – No map 0.034 0.334 No Hit 0.0% —
5374 KP13_02661 hypothetical protein ColabFold model – – No map 0.034 0.388 No Hit 0.0% —
5375 KP13_01101 Transcription elongation protein nusA nusA AlphaFold DB model + ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +69 total
No map 0.034 0.886 No Hit 0.0% —
Page of 234 · 5842 total proteins