Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5842 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5401 KP13_01209 putative symporter AlphaFold + ColabFold –
GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.142 Hit 21.7% 8.94e-06
5402 KP13_00564 5,10-methylenetetrahydrofolate reductase metF AlphaFold + ColabFold
1.5.1.54
GO:0006555The chemical reactions and pathways involving L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. +47 total
0.142 Hit 38.2% 3.52e-24
5403 KP13_06704 hypothetical protein AlphaFold + ColabFold – – 0.141 No Hit 0.0% —
5404 KP13_04936 hypothetical protein ColabFold – – 0.141 No Hit 0.0% —
5405 KP13_31590 Dihydrofolate reductase type 15 dhfrXV AlphaFold + ColabFold
1.5.1.3
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0004146Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. GO:0046654The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. +47 total
0.14 No Hit 0.0% —
5406 KP13_04537 putative monooxygenase AlphaFold + ColabFold –
GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water.
0.14 No Hit 0.0% —
5407 KP13_03739 hypothetical protein AlphaFold + ColabFold – – 0.14 No Hit 0.0% —
5408 KP13_02025 GCN5-related N-acetyltransferase AlphaFold + ColabFold
2.3.1.266
GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0006474The acetylation of the N-terminal amino acid of proteins. +25 total
0.14 Hit 38.6% 9.59e-08
5409 KP13_03910 Flavoprotein wrbA wrbA AlphaFold + ColabFold
1.6.5.2
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0003955Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol. +69 total
0.139 No Hit 0.0% —
5410 KP13_02802 hypothetical protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006744The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
0.139 No Hit 0.0% —
5411 KP13_31949 hypothetical protein AlphaFold + ColabFold – – 0.138 No Hit 0.0% —
5412 KP13_04400 putative ABC transporter system permease protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.138 No Hit 0.0% —
5413 KP13_03939 hypothetical protein ColabFold – – 0.138 No Hit 0.0% —
5414 KP13_00882 hypothetical protein AlphaFold + ColabFold – – 0.138 No Hit 0.0% —
5415 KP13_00217 Putative L-lactate dehydrogenase operon regulatory protein lldR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.138 No Hit 0.0% —
5416 KP13_02313 Propanediol utilization protein PduH pduH AlphaFold + ColabFold – – 0.136 No Hit 0.0% —
5417 KP13_01755 ATPase domain-containing protein AlphaFold + ColabFold –
GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0046872Binding to a metal ion.
0.136 No Hit 0.0% —
5418 KP13_01153 hypothetical protein AlphaFold + ColabFold – – 0.136 No Hit 0.0% —
5419 KP13_02636 hypothetical protein AlphaFold + ColabFold – – 0.135 No Hit 0.0% —
5420 KP13_02195 Tyrosine recombinase xerD xerD AlphaFold + ColabFold –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0009009Catalysis of the formation of new phosphodiester bonds between a pair of short, unique target DNA sequences. +69 total
0.135 No Hit 0.0% —
5421 KP13_01881 Pyruvate dehydrogenase complex repressor pdhR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.135 No Hit 0.0% —
5422 KP13_00266 Ankyrin repeat domain-containing protein AlphaFold + ColabFold –
GO:0005515Binding to a protein.
0.135 Hit 38.6% 4.07e-06
5423 KP13_05475 TIM barrel domain-containing protein AlphaFold + ColabFold – – 0.134 No Hit 0.0% —
5424 KP13_02359 hypothetical protein AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. +58 total
0.134 No Hit 0.0% —
5425 KP13_31860 hypothetical protein AlphaFold + ColabFold – – 0.133 No Hit 0.0% —
Page of 234 · 5842 total proteins