Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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Rows
# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5426 KP13_32115 hypothetical protein ColabFold model – – No map 0.029 0.832 No Hit 0.0% —
5427 KP13_32004 biofilm-dependent modulation domain-containing protein AlphaFold DB model + ColabFold model –
GO:0071468Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
No map N/A 0.029 No Hit 0.0% —
5428 KP13_06686 Phosphatidylinositol-specific phospholipase C ColabFold model – – No map 0.029 0.677 No Hit 0.0% —
5429 KP13_06624 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0009061The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor.
No map 0.029 0.586 No Hit 0.0% —
5430 KP13_04874 Spermidine/putrescine transport system permease protein potB potB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.029 0.615 No Hit 0.0% —
5431 KP13_04566 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.029 No Hit 0.0% —
5432 KP13_04470 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.029 0.684 No Hit 0.0% —
5433 KP13_03872 hypothetical protein ColabFold model – – No map 0.029 0.624 No Hit 0.0% —
5434 KP13_03492 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.029 0.826 No Hit 0.0% —
5435 KP13_03287 putative transmembrane protein AlphaFold DB model + ColabFold model – – No map 0.029 0.93 No Hit 0.0% —
5436 KP13_02646 plasmid maintenance killer protein AlphaFold DB model + ColabFold model – – No map 0.029 0.158 No Hit 0.0% —
5437 KP13_02134 Phosphonate transport system permease protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015416Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). GO:0015716The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). +25 total
No map 0.029 0.889 No Hit 0.0% —
5438 KP13_01953 DnaJ-like protein djlA djlA AlphaFold DB model + ColabFold model –
GO:0051087Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.029 0.968 No Hit 0.0% —
5439 KP13_31876 hypothetical protein ColabFold model – – No map N/A 0.028 No Hit 0.0% —
5440 KP13_05313 Gluconate 2-dehydrogenase subunit 3 AlphaFold DB model + ColabFold model – – No map 0.028 0.222 No Hit 0.0% —
5441 KP13_04499 Tautomerase pptA pptA AlphaFold DB model + ColabFold model
5.3.2.-
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0016862Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears. GO:0006725OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. +14 total
No map 0.028 0.541 No Hit 0.0% —
5442 KP13_03884 Acylphosphatase acyP AlphaFold DB model + ColabFold model
3.6.1.7
GO:0003998Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate.
No map 0.028 0.096 Hit 35.4% 4.64e-08
5443 KP13_03426 Inhibitor of vertebrate lysozyme ivy AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0043086Any process that stops or reduces the activity of an enzyme.
No map 0.028 0.285 No Hit 0.0% —
5444 KP13_02803 Glycogen synthesis protein glgS glgS AlphaFold DB model + ColabFold model –
GO:1902201Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum-dependent cell motility. GO:1900191Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation.
No map 0.028 0.318 No Hit 0.0% —
5445 KP13_02635 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.028 0.711 No Hit 0.0% —
5446 KP13_01648 Ribose/galactose isomerase family protein AlphaFold DB model + ColabFold model –
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016861Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears.
No map 0.028 0.583 No Hit 0.0% —
5447 KP13_12850 putative membrane protein AlphaFold DB model + ColabFold model – – No map 0.027 0.697 No Hit 0.0% —
5448 KP13_05536 putative PTS family enzyme IIA/ enzyme IIBC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
No map 0.027 0.295 No Hit 0.0% —
5449 KP13_05220 Chaperone protein lpfB lpfB AlphaFold DB model + ColabFold model –
GO:0061077OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +14 total
No map 0.027 0.379 No Hit 0.0% —
5450 KP13_03679 hypothetical protein ColabFold model – – No map 0.027 0.492 No Hit 0.0% —
Page of 234 · 5842 total proteins