Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5576 KP13_04863 Phosphatase nudJ nudJ AlphaFold DB model + ColabFold model
3.6.1.-
GO:0017111Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate. GO:0004787Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate. GO:0017110Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate. +14 total
No map 0.086 Hit 28.4% 3.26e-06
5577 KP13_04140 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0046872Binding to a metal ion.
No map 0.086 No Hit 0.0% —
5578 KP13_03960 hypothetical protein ColabFold model – – No map 0.086 No Hit 0.0% —
5579 KP13_02975 p-hydroxybenzoic acid efflux pump subunit aaeA aaeA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.086 No Hit 0.0% —
5580 KP13_31576 Multidrug resistance protein A AlphaFold DB model + ColabFold model –
GO:1990961A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
No map 0.085 No Hit 0.0% —
5581 KP13_04398 putative ABC transporter ATP-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
No map 0.085 Hit 40.3% 1.11e-06
5582 KP13_02099 putative isochorismatase AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.085 No Hit 0.0% —
5583 KP13_04131 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.084 No Hit 0.0% —
5584 KP13_01419 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.084 No Hit 0.0% —
5585 KP13_04589 Coenzyme PQQ synthesis protein B pqqB AlphaFold DB model + ColabFold model –
GO:0018189The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed.
No map 0.083 No Hit 0.0% —
5586 KP13_04463 Putative ABC transporter periplasmic-binding protein AlphaFold DB model + ColabFold model –
GO:0015846The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0019808Binding to a polyamine, an organic compound containing two or more amino groups. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +14 total
No map 0.083 No Hit 0.0% —
5587 KP13_01054 hypothetical protein ColabFold model – – No map 0.083 No Hit 0.0% —
5588 KP13_00871 Putative prophage CPS-53 integrase intS AlphaFold DB model + ColabFold model –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.083 No Hit 0.0% —
5589 KP13_00654 putative N-acetyltransferase AlphaFold DB model + ColabFold model
2.3.1.-
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.083 No Hit 0.0% —
5590 KP13_31795 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.082 No Hit 0.0% —
5591 KP13_03991 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.082 No Hit 0.0% —
5592 KP13_01085 hypothetical protein ColabFold model – – No map 0.082 No Hit 0.0% —
5593 KP13_32382 hypothetical protein ColabFold model – – No map 0.081 No Hit 0.0% —
5594 KP13_01887 1,6-anhydro-N-acetylmuramyl-L-alanine amidase ampD ampD ColabFold model –
GO:0009253The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0008745Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides.
No map 0.081 No Hit 0.0% —
5595 KP13_01543 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.081 No Hit 0.0% —
5596 KP13_32023 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.08 No Hit 0.0% —
5597 KP13_00878 Prophage CP4-57 regulatory protein AlphaFold DB model + ColabFold model – – No map 0.08 No Hit 0.0% —
5598 KP13_32145 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.079 No Hit 0.0% —
5599 KP13_02393 6-carboxy-5,6,7,8-tetrahydropterin synthase queD AlphaFold DB model + ColabFold model
4.-.-.-
GO:0070497Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+. GO:0046872Binding to a metal ion. GO:0008616The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in position 34 of tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon.
No map 0.079 Hit 37.1% 9.67e-12
5600 KP13_02169 D-3-phosphoglycerate dehydrogenase serA AlphaFold DB model + ColabFold model
1.1.1.399 1.1.1.95
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
No map 0.079 Hit 41.3% 9.22e-06
Page of 234 · 5842 total proteins