Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5626 KP13_02150 Adhesion domain-containing protein ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.
0.074 No Hit 0.0% —
5627 KP13_01585 putative transposase AlphaFold + ColabFold – – 0.074 No Hit 0.0% —
5628 KP13_01290 Aspartate carbamoyltransferase pyrB AlphaFold + ColabFold
2.1.3.2
GO:0006207The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. GO:0016597Binding to an amino acid, organic acids containing one or more amino substituents. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. +47 total
0.074 Hit 42.3% 1.23e-74
5629 KP13_01069 putative transposase AlphaFold + ColabFold – – 0.074 No Hit 0.0% —
5630 KP13_05586 hypothetical protein AlphaFold + ColabFold – – 0.073 No Hit 0.0% —
5631 KP13_00114 hypothetical protein AlphaFold + ColabFold – – 0.073 No Hit 0.0% —
5632 KP13_05287 hypothetical protein ColabFold – – 0.072 No Hit 0.0% —
5633 KP13_04307 Inner membrane transporter rhtA rhtA ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.072 No Hit 0.0% —
5634 KP13_05646 hypothetical protein ColabFold – – 0.071 No Hit 0.0% —
5635 KP13_04189 hypothetical protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. GO:0043164A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Gram-negative bacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane. +14 total
0.071 No Hit 0.0% —
5636 KP13_02460 Fimbrial-like protein AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.071 No Hit 0.0% —
5637 KP13_01005 putative Nudix hydrolase AlphaFold + ColabFold –
GO:0016817Catalysis of the hydrolysis of any acid anhydride. GO:0046872Binding to a metal ion.
0.071 No Hit 0.0% —
5638 KP13_31923 Putative ABC transporter arginine-binding protein 2 artI AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0071705The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +25 total
0.07 No Hit 0.0% —
5639 KP13_06690 hypothetical protein AlphaFold + ColabFold – – 0.07 No Hit 0.0% —
5640 KP13_04148 Tellurium resistance protein terD terD AlphaFold + ColabFold –
GO:0046690Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus.
0.07 No Hit 0.0% —
5641 KP13_03470 Putative phosphosugar isomerase AlphaFold + ColabFold –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0097367Binding to a carbohydrate derivative.
0.07 Hit 22.9% 8.78e-10
5642 KP13_02639 hypothetical protein AlphaFold + ColabFold – – 0.07 No Hit 0.0% —
5643 KP13_01708 Protein cyaY cyaY AlphaFold + ColabFold –
GO:0008199Binding to a ferric iron ion, Fe(III). GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.07 No Hit 0.0% —
5644 KP13_01374 NADH pyrophosphatase nudC AlphaFold + ColabFold
3.6.1.- 3.6.1.22
GO:0000210Catalysis of the reaction: NAD+ + H2O = AMP + NMN. GO:0046872Binding to a metal ion. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +811 total
0.07 Hit 40.7% 1.43e-19
5645 KP13_05032 Methylated-DNA--protein-cysteine methyltransferase ogt AlphaFold + ColabFold
2.1.1.63
GO:0003908Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. +36 total
0.069 Hit 45.5% 2.50e-21
5646 KP13_01498 hypothetical protein AlphaFold + ColabFold – – 0.068 No Hit 0.0% —
5647 KP13_31608 putative lipoprotein AlphaFold + ColabFold – – 0.067 No Hit 0.0% —
5648 KP13_05504 GCN5-related N-acetyltransferase AlphaFold + ColabFold
2.3.1.-
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.067 No Hit 0.0% —
5649 KP13_02556 N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA component chbA AlphaFold + ColabFold –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0046872Binding to a metal ion. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.067 No Hit 0.0% —
5650 KP13_02502 4-hydroxyphenylacetate 3-monooxygenase reductase component hpaC AlphaFold + ColabFold
1.5.1.36
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016651Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. +47 total
0.067 No Hit 0.0% —
Page of 234 · 5842 total proteins