Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5526 KP13_02606 Carbon storage regulator csrA AlphaFold + ColabFold –
GO:0006109Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. GO:0006402The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. GO:0003723Binding to an RNA molecule or a portion thereof.
0.103 No Hit 0.0% —
5527 KP13_00767 50S ribosomal protein L30 rpmD AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0015934The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
0.103 No Hit 0.0% —
5528 KP13_00705 Protein damX damX AlphaFold + ColabFold –
GO:0042834Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. GO:0030428A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. GO:0032506A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells).
0.103 No Hit 0.0% —
5529 KP13_32179 ABC transporter periplasmic-binding protein AlphaFold + ColabFold –
GO:0030313An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.102 No Hit 0.0% —
5530 KP13_01166 Thermostable carboxypeptidase 1 AlphaFold + ColabFold
3.4.17.19
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0004181Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0008270Binding to a zinc ion (Zn).
0.102 No Hit 0.0% —
5531 KP13_00828 Nitrogen regulatory protein P-II glnB AlphaFold + ColabFold –
GO:0030234A molecular function regulator that modulates a catalytic activity. GO:0006808Any process that modulates the frequency, rate or extent of nitrogen utilization. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.102 No Hit 0.0% —
5532 KP13_05472 hypothetical protein AlphaFold + ColabFold – – 0.101 No Hit 0.0% —
5533 KP13_05111 hypothetical protein AlphaFold + ColabFold – – 0.101 No Hit 0.0% —
5534 KP13_03358 Thiol:disulfide interchange protein dsbG dsbG AlphaFold + ColabFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.101 No Hit 0.0% —
5535 KP13_05134 Acid shock protein AlphaFold + ColabFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.1 No Hit 0.0% —
5536 KP13_04760 hypothetical protein AlphaFold + ColabFold – – 0.1 No Hit 0.0% —
5537 KP13_02911 Sigma factor-binding protein crl crl AlphaFold + ColabFold –
GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.1 No Hit 0.0% —
5538 KP13_01408 Type IV restriction endonuclease family protein AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0009307A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
0.1 No Hit 0.0% —
5539 KP13_03104 hypothetical protein ColabFold – – 0.099 No Hit 0.0% —
5540 KP13_00457 putative transcriptional regulator phnF phnF AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.099 No Hit 0.0% —
5541 KP13_02677 hypothetical protein ColabFold – – 0.098 No Hit 0.0% —
5542 KP13_02127 hypothetical protein AlphaFold + ColabFold – – 0.098 No Hit 0.0% —
5543 KP13_00851 Protein iscX iscX AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
0.098 No Hit 0.0% —
5544 KP13_03048 hypothetical protein AlphaFold + ColabFold – – 0.097 No Hit 0.0% —
5545 KP13_03884 Acylphosphatase acyP AlphaFold + ColabFold
3.6.1.7
GO:0003998Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate.
0.096 Hit 35.4% 4.64e-08
5546 KP13_01143 hypothetical protein AlphaFold + ColabFold –
GO:0003697Binding to single-stranded DNA. GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. GO:0018142OBSOLETE. The formation of a covalent cross-link between DNA and a protein.
0.096 Hit 33.3% 2.35e-07
5547 KP13_01078 Penicillin-binding protein activator LpoA lpoA AlphaFold + ColabFold –
GO:0005515Binding to a protein. GO:0031241The leaflet of a outer cell membrane that faces the periplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0030234A molecular function regulator that modulates a catalytic activity. +25 total
0.096 No Hit 0.0% —
5548 KP13_00844 HTH-type transcriptional regulator iscR iscR AlphaFold + ColabFold –
GO:0003690Binding to double-stranded DNA. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
0.096 No Hit 0.0% —
5549 KP13_00605 hypothetical protein AlphaFold + ColabFold – – 0.096 No Hit 0.0% —
5550 KP13_00580 Regulator of ribonuclease activity A rraA AlphaFold + ColabFold –
GO:0008428Binds to and stops, prevents or reduces the activity of ribonuclease. GO:0051252Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
0.096 No Hit 0.0% —
Page of 234 · 5842 total proteins