Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5526 KP13_05129 hypothetical protein ColabFold model – – No map 0.657 No Hit 0.0% —
5527 KP13_04753 putative tautomerase AlphaFold DB model + ColabFold model – – No map 0.15 No Hit 0.0% —
5528 KP13_04436 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0046872Binding to a metal ion. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
No map 0.02 No Hit 0.0% —
5529 KP13_04064 Glyoxalase/bleomycin resistance protein/dioxygenase AlphaFold DB model + ColabFold model –
GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate.
No map 0.293 No Hit 0.0% —
5530 KP13_01860 Putative phosphotransferase enzyme IIA component AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.204 No Hit 0.0% —
5531 KP13_01194 hypothetical protein ColabFold model – – No map 0.408 No Hit 0.0% —
5532 KP13_00813 Ribonuclease 3 rnc AlphaFold DB model + ColabFold model
3.1.26.3
GO:0004525Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. +912 total
No map 0.374 Hit 35.1% 9.48e-07
5533 KP13_00784 DNA topoisomerase, type IA, Zn finger domain-containing protein AlphaFold DB model + ColabFold model –
GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. GO:0003916Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. GO:0003917Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. +25 total
No map 0.767 No Hit 0.0% —
5534 KP13_00083 Transcriptional regulatory protein uhpA uhpA AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
No map 0.205 No Hit 0.0% —
5535 KP13_31625 Transcriptional activator rfaH rfaH AlphaFold DB model + ColabFold model –
GO:0140673A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
No map 0.537 No Hit 0.0% —
5536 KP13_05275 Multiple antibiotic resistance protein marR marR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
No map 0.755 No Hit 0.0% —
5537 KP13_05073 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.559 No Hit 0.0% —
5538 KP13_05004 sirA domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.019 No Hit 0.0% —
5539 KP13_04555 hypothetical protein ColabFold model – – No map 0.722 No Hit 0.0% —
5540 KP13_03987 Conjugal transfer protein TrhY AlphaFold DB model + ColabFold model – – No map 0.567 No Hit 0.0% —
5541 KP13_03915 putative malonic semialdehyde reductase RutE rutE AlphaFold DB model + ColabFold model
1.1.1.298
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0035527Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH. GO:0019740A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism. +14 total
No map 0.566 No Hit 0.0% —
5542 KP13_03823 Glycine cleavage system transcriptional repressor gcvR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.473 No Hit 0.0% —
5543 KP13_02786 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.516 No Hit 0.0% —
5544 KP13_02665 hypothetical protein ColabFold model – – No map 0.205 No Hit 0.0% —
5545 KP13_02642 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.501 No Hit 0.0% —
5546 KP13_02425 30S ribosomal protein S16 rpsP AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +25 total
No map 0.301 Hit 42.7% 3.80e-18
5547 KP13_02192 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0034552The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II. GO:0006105The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle.
No map 0.752 No Hit 0.0% —
5548 KP13_01081 putative transporter protein AlphaFold DB model + ColabFold model – – No map 0.442 No Hit 0.0% —
5549 KP13_00883 Helix-turn-helix type 3 protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.577 No Hit 0.0% —
5550 KP13_00705 Protein damX damX AlphaFold DB model + ColabFold model –
GO:0042834Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. GO:0030428A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. GO:0032506A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells).
No map 0.103 No Hit 0.0% —
Page of 234 · 5842 total proteins