Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5601 KP13_00802 Autonomous glycyl radical cofactor grcA AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008861Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate.
No map 0.079 No Hit 0.0% —
5602 KP13_00779 Ribosomal RNA small subunit methyltransferase B rsmB AlphaFold DB model + ColabFold model
2.1.1.176
GO:0001510Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +69 total
No map 0.079 Hit 34.5% 2.37e-23
5603 KP13_32144 hypothetical protein ColabFold model – – No map 0.078 No Hit 0.0% —
5604 KP13_03341 Rare lipoprotein A rlpA AlphaFold DB model + ColabFold model
4.2.2.-
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0042834Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +47 total
No map 0.078 No Hit 0.0% —
5605 KP13_02051 Glyoxalase/bleomycin resistance domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.078 No Hit 0.0% —
5606 KP13_01473 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.078 No Hit 0.0% —
5607 KP13_04184 peptidoglycan binding-like protein AlphaFold DB model + ColabFold model –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0004180Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +25 total
No map 0.077 No Hit 0.0% —
5608 KP13_03003 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0071468Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
No map 0.077 No Hit 0.0% —
5609 KP13_02500 4-hydroxyphenylacetate catabolism regulatory protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.077 No Hit 0.0% —
5610 KP13_31766 cell division protein FtsY ftsY AlphaFold DB model + ColabFold model
3.6.5.4
GO:0006614The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. GO:0005525Binding to GTP, guanosine triphosphate. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +58 total
No map 0.076 Hit 35.0% 1.48e-31
5611 KP13_03153 Transcriptional regulatory protein baeR baeR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +58 total
No map 0.076 No Hit 0.0% —
5612 KP13_02303 putative propanediol utilization proteni AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map 0.076 No Hit 0.0% —
5613 KP13_00346 4-aminobutyrate aminotransferase puuE Experimental + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0003867OBSOLETE. Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid. +47 total
No map 0.076 Hit 33.1% 3.02e-15
5614 KP13_05156 HlyD-family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.075 No Hit 0.0% —
5615 KP13_04546 putative ABC transporter ATP-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.075 Hit 50.0% 1.36e-06
5616 KP13_32243 putative transposase AlphaFold DB model + ColabFold model – – No map 0.074 No Hit 0.0% —
5617 KP13_32241 putative transposase AlphaFold DB model + ColabFold model – – No map 0.074 No Hit 0.0% —
5618 KP13_32147 putative transposase AlphaFold DB model + ColabFold model – – No map 0.074 No Hit 0.0% —
5619 KP13_06814 putative transposase AlphaFold DB model + ColabFold model – – No map 0.074 No Hit 0.0% —
5620 KP13_04583 Penicillin-binding protein 2 AlphaFold DB model + ColabFold model
3.4.16.4
GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. +69 total
No map 0.074 No Hit 0.0% —
5621 KP13_04125 putative transposase AlphaFold DB model + ColabFold model – – No map 0.074 No Hit 0.0% —
5622 KP13_04120 putative transposase AlphaFold DB model + ColabFold model – – No map 0.074 No Hit 0.0% —
5623 KP13_03959 putative transposase AlphaFold DB model + ColabFold model – – No map 0.074 No Hit 0.0% —
5624 KP13_03730 putative transposase AlphaFold DB model + ColabFold model – – No map 0.074 No Hit 0.0% —
5625 KP13_02155 putative transposase AlphaFold DB model + ColabFold model – – No map 0.074 No Hit 0.0% —
Page of 234 · 5842 total proteins