Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5651 KP13_02197 Single-stranded-DNA-specific exonuclease recJ recJ AlphaFold DB model + ColabFold model –
GO:0008409Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. GO:0003676Binding to a nucleic acid. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. +14 total
No map 0.067 No Hit 0.0% —
5652 KP13_02035 Transcriptional activator protein BglJ bgIJ AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.067 No Hit 0.0% —
5653 KP13_00581 6-phosphofructokinase pfkA AlphaFold DB model + ColabFold model
2.7.1.11
GO:0008443Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule. GO:0006002The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +1013 total
No map 0.066 Hit 57.8% 6.10e-09
5654 KP13_00787 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.065 No Hit 0.0% —
5655 KP13_32366 putative reverse transcriptase AlphaFold DB model + ColabFold model –
GO:0003964Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time.
No map 0.062 No Hit 0.0% —
5656 KP13_31995 putative reverse transcriptase AlphaFold DB model + ColabFold model – – No map 0.062 No Hit 0.0% —
5657 KP13_31958 putative reverse transcriptase AlphaFold DB model + ColabFold model – – No map 0.062 No Hit 0.0% —
5658 KP13_31886 putative reverse transcriptase retA AlphaFold DB model + ColabFold model – – No map 0.062 No Hit 0.0% —
5659 KP13_01660 putative amino-acid ABC transporter ATP-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003333The process in which an amino acid is transported across a membrane. +25 total
No map 0.062 Hit 37.1% 5.41e-27
5660 KP13_04651 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.061 No Hit 0.0% —
5661 KP13_02229 Fimbrin-like protein fimI fimI AlphaFold DB model + ColabFold model –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
No map 0.061 No Hit 0.0% —
5662 KP13_00725 putative phosphoribulokinase prkB AlphaFold DB model + ColabFold model
2.7.1.19
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +14 total
No map 0.061 No Hit 0.0% —
5663 KP13_00274 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.061 No Hit 0.0% —
5664 KP13_02156 Fimbria A protein smfA AlphaFold DB model + ColabFold model –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
No map 0.06 No Hit 0.0% —
5665 KP13_01836 General secretion pathway protein C Experimental + AlphaFold DB model + ColabFold model –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0005515Binding to a protein. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. +14 total
No map 0.059 No Hit 0.0% —
5666 KP13_00577 ATP-dependent protease hslV hslV AlphaFold DB model + ColabFold model
3.4.25.2
GO:0004298Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0051603OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. +36 total
No map 0.059 No Hit 0.0% —
5667 KP13_06798 hypothetical protein ColabFold model – – No map 0.058 No Hit 0.0% —
5668 KP13_05514 amino acid ABC transporter, ATP-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003333The process in which an amino acid is transported across a membrane. +25 total
No map 0.058 Hit 61.1% 1.27e-06
5669 KP13_03175 Rossmann-like alpha/beta/alpha sandwich fold domain-containing protein ColabFold model – – No map 0.058 No Hit 0.0% —
5670 KP13_31535 putative transposase ColabFold model – – No map 0.057 No Hit 0.0% —
5671 KP13_05300 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.057 No Hit 0.0% —
5672 KP13_01070 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.057 No Hit 0.0% —
5673 KP13_32367 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.056 No Hit 0.0% —
5674 KP13_03863 ABC transporter ATP-binding protein uup uup AlphaFold DB model + ColabFold model
3.6.1.-
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. +36 total
No map 0.056 Hit 36.5% 1.00e-14
5675 KP13_02801 3,4-dihydroxy-2-butanone 4-phosphate synthase ribB AlphaFold DB model + ColabFold model –
GO:0008686Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H+. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
No map 0.056 No Hit 0.0% —
Page of 234 · 5842 total proteins