Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
576 KP13_03496 putative MFS general substrate transporter AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.943 0.919 No Hit 0.0% —
577 KP13_03380 putative MFS general substrate transporter AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +47 total
No map 0.943 0.745 Hit 31.2% 7.93e-10
578 KP13_02771 putative sodium: galactoside symporter AlphaFold DB model + ColabFold model –
GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
No map 0.943 0.83 Hit 31.0% 1.51e-13
579 KP13_01976 hypothetical protein ColabFold model – – No map N/A 0.943 No Hit 0.0% —
580 KP13_01807 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr AlphaFold DB model + ColabFold model
1.1.1.267
GO:0070402Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. GO:0046872Binding to a metal ion. GO:0030604Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + H+ + NADPH. +47 total
No map 0.943 0.956 No Hit 0.0% —
581 KP13_01429 Ribosomal RNA small subunit methyltransferase H rsmH AlphaFold DB model + ColabFold model
2.1.1.199
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0071424Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine. +14 total
No map 0.943 0.527 Hit 37.8% 4.82e-17
582 KP13_01294 Fructosamine deglycase frlB frlB AlphaFold DB model + ColabFold model –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0097367Binding to a carbohydrate derivative. GO:0004360Catalysis of the reaction: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. +47 total
No map 0.943 0.969 Hit 21.0% 3.79e-06
583 KP13_00293 2-dehydro-3-deoxygluconokinase AlphaFold DB model + ColabFold model
2.7.1.45
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008673Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H+. +47 total
No map 0.943 0.228 No Hit 0.0% —
584 KP13_00150 Glycerol kinase glpK AlphaFold DB model + ColabFold model
2.7.1.30
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +69 total
No map 0.943 0.891 Hit 49.0% 2.45e-07
585 KP13_05557 Phosphoglycerate transporter protein pgtP AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +47 total
No map 0.942 0.425 Hit 33.0% 1.73e-22
586 KP13_05271 Major facilitator superfamily transporter AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.942 0.819 Hit 31.7% 2.63e-07
587 KP13_05035 Aminobenzoyl-glutamate utilization protein B abgB AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016805Catalysis of the hydrolysis of a dipeptide. +25 total
No map 0.942 0.748 Hit 24.5% 1.67e-24
588 KP13_04375 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.942 0.919 No Hit 0.0% —
589 KP13_03852 Ethanolamine utilization protein eutA eutA AlphaFold DB model + ColabFold model –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0046336The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine).
No map 0.942 0.854 No Hit 0.0% —
590 KP13_03826 Phosphoribosylaminoimidazole-succinocarboxamide synthase purC AlphaFold DB model + ColabFold model –
GO:0004639Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate. GO:0006164The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
No map 0.942 0.434 Hit 31.7% 8.26e-28
591 KP13_03630 Acriflavine resistance protein B acrB Experimental + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0042908The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +58 total
No map 0.942 0.997 No Hit 0.0% —
592 KP13_03384 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.942 0.726 No Hit 0.0% —
593 KP13_03308 OprD-like protein oprD AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0046930A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids. +47 total
No map 0.942 0.96 No Hit 0.0% —
594 KP13_02334 Sirohydrochlorin cobaltochelatase cbiK AlphaFold DB model + ColabFold model
4.99.1.3
GO:0019251The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen. GO:0016852Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+. GO:0046872Binding to a metal ion.
No map 0.942 0.61 No Hit 0.0% —
595 KP13_02240 Outer membrane usher protein mrkC mrkC AlphaFold DB model + ColabFold model –
GO:0005515Binding to a protein. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473A porin that acts in the assembly of fimbria together with fimbrial chaperone. +25 total
No map 0.942 0.209 No Hit 0.0% —
596 KP13_02008 Trifunctional NAD biosynthesis/regulator protein NadR nadR AlphaFold DB model + ColabFold model
2.7.1.22 2.7.7.1
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0009435The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3. GO:0000309Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + ATP + H+ = diphosphate + NAD+. +69 total
No map 0.942 0.958 No Hit 0.0% —
597 KP13_01812 Methionine aminopeptidase map AlphaFold DB model + ColabFold model
3.4.11.18
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0070006Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.942 0.865 Hit 50.7% 5.43e-17
598 KP13_01706 Porphobilinogen deaminase hemC AlphaFold DB model + ColabFold model
2.5.1.61
GO:0004418Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4. GO:0033014The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. GO:0018160The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine. +25 total
No map 0.942 0.52 Hit 47.3% 4.91e-50
599 KP13_01570 Para-aminobenzoate synthase component 1 pabB AlphaFold DB model + ColabFold model
2.6.1.85
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0009396The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. GO:0046820Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate. +36 total
No map 0.942 0.82 No Hit 0.0% —
600 KP13_01470 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.942 No Hit 0.0% —
Page of 234 · 5842 total proteins