Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1051 KP13_00168 putative inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.834 No Hit 0.0% —
1052 KP13_01939 Inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.833 No Hit 0.0% —
1053 KP13_01219 L-ribulose-5-phosphate 4-epimerase ulaF ulaF AlphaFold + ColabFold
5.1.3.4
GO:0008742Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016832Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. +36 total
0.833 No Hit 0.0% —
1054 KP13_04926 Ribonuclease E rne AlphaFold + ColabFold
3.1.26.12
GO:0003676Binding to a nucleic acid. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0003723Binding to an RNA molecule or a portion thereof. +1114 total
0.832 No Hit 0.0% —
1055 KP13_04773 Putative quinone oxidoreductase AlphaFold + ColabFold
1.3.1.95 1.3.1.84 1.6.5.-
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0043958Catalysis of the reaction: propanoyl-CoA + NAD+ = acryloyl-CoA + H+ + NADH. GO:0043957Catalysis of the reaction: acryloyl-CoA + NADPH + H+ = propionyl-CoA + NADP+.
0.832 Hit 29.1% 1.23e-07
1056 KP13_04438 PQQ-dependent dehydrogenase, glucose/quinate/shikimate family AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016614Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +36 total
0.832 No Hit 0.0% —
1057 KP13_01745 Trk system potassium uptake protein trkH trkH AlphaFold + ColabFold –
GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0071805A process in which a potassium ion is transported from one side of a membrane to the other. GO:0008324Enables the transfer of cation from one side of a membrane to the other. +58 total
0.832 No Hit 0.0% —
1058 KP13_01475 ImpA domain-containing protein AlphaFold + ColabFold – – 0.832 No Hit 0.0% —
1059 KP13_12882 Major facilitator superfamily transporter AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.831 No Hit 0.0% —
1060 KP13_06719 hypothetical protein AlphaFold + ColabFold – – 0.831 No Hit 0.0% —
1061 KP13_04239 putative diguanylate cyclase AlphaFold + ColabFold
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0005525Binding to GTP, guanosine triphosphate. +25 total
0.831 No Hit 0.0% —
1062 KP13_03925 hypothetical protein AlphaFold + ColabFold – – 0.831 No Hit 0.0% —
1063 KP13_05520 hypothetical protein AlphaFold + ColabFold – – 0.83 No Hit 0.0% —
1064 KP13_03363 Enolase-phosphatase E1 mtnC AlphaFold + ColabFold
3.1.3.77
GO:0043874Catalysis of the reactions:5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate. GO:0000287Binding to a magnesium (Mg) ion. GO:0019509OBSOLETE. The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. +25 total
0.83 Hit 42.9% 3.32e-40
1065 KP13_02771 putative sodium: galactoside symporter AlphaFold + ColabFold –
GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
0.83 Hit 31.0% 1.51e-13
1066 KP13_02621 Glycine betaine/L-proline transport system permease protein proW proW AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +47 total
0.83 No Hit 0.0% —
1067 KP13_02368 Acyl-CoA dehydrogenase family protein AlphaFold + ColabFold –
GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0008470Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]. +14 total
0.83 No Hit 0.0% —
1068 KP13_01509 Type IV/VI secretion system domain-containing protein AlphaFold + ColabFold – – 0.83 No Hit 0.0% —
1069 KP13_01076 D-galactarate dehydratase garD AlphaFold + ColabFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0008867Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O. GO:0046392The chemical reactions and pathways resulting in the breakdown of D-galactarate, the anion of galactaric acid.
0.83 No Hit 0.0% —
1070 KP13_00256 2-dehydro-3-deoxygluconokinase kdgK AlphaFold + ColabFold –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
0.83 Hit 25.5% 1.75e-06
1071 KP13_31937 hypothetical protein AlphaFold + ColabFold – – 0.829 No Hit 0.0% —
1072 KP13_31602 HTH-type transcriptional regulator ilvY ilvY AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
0.829 No Hit 0.0% —
1073 KP13_16529 Transport-associated and nodulation domain-containing protein AlphaFold + ColabFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.829 No Hit 0.0% —
1074 KP13_05027 NAD(P) transhydrogenase subunit alpha pntA AlphaFold + ColabFold
7.1.1.1
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008746OBSOLETE. Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. GO:1902600The directed movement of a proton across a membrane. +47 total
0.829 Hit 57.4% 4.94e-11
1075 KP13_02149 hypothetical protein AlphaFold + ColabFold – – 0.829 No Hit 0.0% —
Page of 208 · 5192 total proteins