Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1126 KP13_03697 putative oxidoreductase AlphaFold DB model + ColabFold model –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
No map 0.881 0.422 Hit 26.5% 2.69e-07
1127 KP13_01170 Spermidine export protein mdtI mdtI AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015848The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
No map N/A 0.881 No Hit 0.0% —
1128 KP13_01089 putative protease AlphaFold DB model + ColabFold model –
GO:0006744The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion.
No map 0.881 0.799 No Hit 0.0% —
1129 KP13_31598 HTH-type transcriptional regulator galS galS AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.880 0.919 No Hit 0.0% —
1130 KP13_31490 Beta-hexosaminidase nagZ AlphaFold DB model + ColabFold model
3.2.1.52
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0004563Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. +69 total
No map 0.880 0.744 No Hit 0.0% —
1131 KP13_12738 Disulfide bond formation protein B dsbB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
No map 0.880 0.956 No Hit 0.0% —
1132 KP13_02994 Galactose-1-phosphate uridylyltransferase galT AlphaFold DB model + ColabFold model
2.7.7.12
GO:0006012The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. GO:0008270Binding to a zinc ion (Zn). GO:0033499The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose. +25 total
No map 0.880 0.868 Hit 58.6% 4.52e-18
1133 KP13_01549 Alanine racemase, catabolic dadB AlphaFold DB model + ColabFold model
5.1.1.1
GO:0006522OBSOLETE. The chemical reactions and pathways involving alanine, 2-aminopropanoic acid. GO:0008784Catalysis of the reaction: L-alanine = D-alanine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +47 total
No map 0.880 0.121 No Hit 0.0% —
1134 KP13_00558 Phosphoenolpyruvate carboxylase ppc AlphaFold DB model + ColabFold model
4.1.1.31
GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008964Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-. +47 total
No map 0.880 0.957 No Hit 0.0% —
1135 KP13_00321 Nickel-binding periplasmic protein nikA AlphaFold DB model + ColabFold model –
GO:0016151Binding to a nickel (Ni) cation. GO:0015675The directed movement of nickel (Ni) cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +58 total
No map 0.880 0.193 No Hit 0.0% —
1136 KP13_00254 Glyoxylate/hydroxypyruvate reductase B ghrB AlphaFold DB model + ColabFold model
1.1.1.79 1.1.1.81
GO:0016618Catalysis of the reaction: (R)-glycerate + NAD(P)+ = 3-hydroxypyruvate + NAD(P)H + H+. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0030267Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+. +58 total
No map 0.880 0.427 Hit 40.2% 3.45e-58
1137 KP13_31531 Wzx flippase in cps region wzx AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.879 0.738 No Hit 0.0% —
1138 KP13_04468 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.879 No Hit 0.0% —
1139 KP13_03608 pheromone shutdown protein TraB AlphaFold DB model + ColabFold model – – No map 0.879 0.944 No Hit 0.0% —
1140 KP13_02252 Oligogalacturonate lyase AlphaFold DB model + ColabFold model –
GO:0045490The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. GO:0005515Binding to a protein. GO:0047487Catalysis of the reaction: 4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate.
No map 0.879 0.045 No Hit 0.0% —
1141 KP13_00441 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.879 0.593 No Hit 0.0% —
1142 KP13_00038 Phosphatase AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0046872Binding to a metal ion.
No map 0.879 0.924 No Hit 0.0% —
1143 KP13_00035 Putative outer membrane porin bglH bglH AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034219The process in which a carbohydrate is transported across a membrane. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. +58 total
No map 0.879 0.896 No Hit 0.0% —
1144 KP13_31491 Polyribonucleotide nucleotidyltransferase pnp AlphaFold DB model + ColabFold model
2.7.7.8
GO:0004654Catalysis of the reaction: RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate. GO:0003676Binding to a nucleic acid. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. +58 total
No map 0.878 0.435 Hit 44.6% 2.39e-08
1145 KP13_04830 Major facilitator superfamily domain-containing protein 3 mfsD3 AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.878 0.885 Hit 28.2% 2.26e-06
1146 KP13_04538 Glutathione import ATP-binding protein GsiA AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
No map 0.878 0.412 Hit 59.0% 2.22e-07
1147 KP13_04512 Respiratory nitrate reductase 2 alpha chain narZ AlphaFold DB model + ColabFold model
1.7.5.1
GO:0009325An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +811 total
No map 0.878 0.885 No Hit 0.0% —
1148 KP13_03312 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.878 No Hit 0.0% —
1149 KP13_03018 Imidazolonepropionase hutI AlphaFold DB model + ColabFold model
3.5.2.7
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. +69 total
No map 0.878 0.465 Hit 34.1% 1.44e-54
1150 KP13_00525 ribokinase-like superfamily protein AlphaFold DB model + ColabFold model –
GO:0052855Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + H+ + NAD(P)H + phosphate. GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
No map 0.878 0.338 Hit 29.4% 1.74e-12
Page of 234 · 5842 total proteins