Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1126 KP13_00307 Phosphatidic acid phosphatase family protein AlphaFold + ColabFold –
GO:0003993Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.837 No Hit 0.0% —
1127 KP13_31592 GCN5-related N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.836 No Hit 0.0% —
1128 KP13_18595 Methionyl-tRNA synthetase metG AlphaFold + ColabFold
6.1.1.10
GO:0006431The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0000049Binding to a transfer RNA. +69 total
0.836 Hit 42.6% 7.73e-06
1129 KP13_05068 DsbA-like thioredoxin domain-containing protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.836 No Hit 0.0% —
1130 KP13_04877 Aldehyde dehydrogenase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
0.836 No Hit 0.0% —
1131 KP13_04601 Methanesulfonate monooxygenase msuD AlphaFold + ColabFold –
GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. GO:0008726Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN. GO:0046306The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group.
0.836 No Hit 0.0% —
1132 KP13_04056 hypothetical protein AlphaFold + ColabFold – – 0.836 No Hit 0.0% —
1133 KP13_02745 putative Fe(2+)-trafficking protein AlphaFold + ColabFold –
GO:0005506Binding to an iron (Fe) ion. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0034599Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
0.836 No Hit 0.0% —
1134 KP13_02664 putative transmembrane protein AlphaFold + ColabFold – – 0.836 No Hit 0.0% —
1135 KP13_01316 5-dehydro-2-deoxygluconokinase iolC AlphaFold + ColabFold –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
0.836 No Hit 0.0% —
1136 KP13_00991 NADH-quinone oxidoreductase subunit C/D nuoC AlphaFold + ColabFold
7.1.1.-
GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0030964An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. GO:0050136Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. +58 total
0.836 Hit 44.5% 2.06e-32
1137 KP13_00224 hypothetical protein AlphaFold + ColabFold – – 0.836 No Hit 0.0% —
1138 KP13_00167 DNA ligase B ligB AlphaFold + ColabFold
6.5.1.2
GO:0003911Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m). GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0006259Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. +14 total
0.836 No Hit 0.0% —
1139 KP13_00139 Antibiotic biosynthesis monooxygenase domain-containing protein AlphaFold + ColabFold –
GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water.
0.836 No Hit 0.0% —
1140 KP13_00118 Drug resistance transporter, Bcr/CflA subfamily protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:1990961A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
0.836 No Hit 0.0% —
1141 KP13_32071 resolvase AlphaFold + ColabFold –
GO:0000150Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
0.835 No Hit 0.0% —
1142 KP13_04244 Arginine ABC transporter permease protein artQ artQ AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +36 total
0.835 No Hit 0.0% —
1143 KP13_02547 putative transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.835 No Hit 0.0% —
1144 KP13_02015 Thymidine phosphorylase deoA AlphaFold + ColabFold
2.4.2.4
GO:0006206The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. GO:0009032Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). +69 total
0.835 Hit 51.9% 8.49e-09
1145 KP13_00570 Cystathionine gamma-synthase metB AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019346The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. +47 total
0.835 Hit 41.9% 1.26e-88
1146 KP13_05289 AraC family transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.834 No Hit 0.0% —
1147 KP13_03892 Putative dioxygenase subunit beta AlphaFold + ColabFold
1.14.13.239
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. +36 total
0.834 No Hit 0.0% —
1148 KP13_03375 putative nucleobase transporter AlphaFold + ColabFold –
GO:0015209Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
0.834 No Hit 0.0% —
1149 KP13_02767 hypothetical protein AlphaFold + ColabFold – – 0.834 No Hit 0.0% —
1150 KP13_02245 hypothetical protein Experimental + ColabFold –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.834 No Hit 0.0% —
Page of 234 · 5842 total proteins