Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1176 KP13_01509 Type IV/VI secretion system domain-containing protein AlphaFold + ColabFold – – 0.83 No Hit 0.0% —
1177 KP13_01076 D-galactarate dehydratase garD AlphaFold + ColabFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0008867Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O. GO:0046392The chemical reactions and pathways resulting in the breakdown of D-galactarate, the anion of galactaric acid.
0.83 No Hit 0.0% —
1178 KP13_00256 2-dehydro-3-deoxygluconokinase kdgK AlphaFold + ColabFold –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
0.83 Hit 25.5% 1.75e-06
1179 KP13_31937 hypothetical protein AlphaFold + ColabFold – – 0.829 No Hit 0.0% —
1180 KP13_31602 HTH-type transcriptional regulator ilvY ilvY AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
0.829 No Hit 0.0% —
1181 KP13_16529 Transport-associated and nodulation domain-containing protein AlphaFold + ColabFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.829 No Hit 0.0% —
1182 KP13_05027 NAD(P) transhydrogenase subunit alpha pntA AlphaFold + ColabFold
7.1.1.1
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008746OBSOLETE. Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. GO:1902600The directed movement of a proton across a membrane. +47 total
0.829 Hit 57.4% 4.94e-11
1183 KP13_02149 hypothetical protein AlphaFold + ColabFold – – 0.829 No Hit 0.0% —
1184 KP13_01010 Epimerase family protein AlphaFold + ColabFold – – 0.829 Hit 47.8% 2.33e-10
1185 KP13_32204 hypothetical protein AlphaFold + ColabFold – – 0.828 No Hit 0.0% —
1186 KP13_31880 Malonyl-CoA O-methyltransferase BioC bioC AlphaFold + ColabFold
2.1.1.197
GO:0010340Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +36 total
0.828 Hit 25.3% 2.66e-09
1187 KP13_04973 putative enoyl-CoA hydratase paaG paaG AlphaFold + ColabFold –
GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.828 Hit 37.1% 7.35e-07
1188 KP13_04821 Pesticin receptor fyuA AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015891The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015343Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). +14 total
0.828 No Hit 0.0% —
1189 KP13_04792 hypothetical protein ColabFold – – 0.828 No Hit 0.0% —
1190 KP13_03726 hypothetical protein AlphaFold + ColabFold – – 0.828 No Hit 0.0% —
1191 KP13_03242 hypothetical protein ColabFold – – 0.828 No Hit 0.0% —
1192 KP13_02945 hypothetical protein AlphaFold + ColabFold – – 0.828 No Hit 0.0% —
1193 KP13_02572 Formate hydrogenlyase regulatory protein hycA hycA AlphaFold + ColabFold – – 0.828 No Hit 0.0% —
1194 KP13_02355 L-fucose-proton symporter fucP AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0015535Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in). GO:0015756The process in which fucose is transported across a lipid bilayer, from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose. +36 total
0.828 No Hit 0.0% —
1195 KP13_01175 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase mdcB AlphaFold + ColabFold
2.4.2.52
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0046917Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine. +14 total
0.828 No Hit 0.0% —
1196 KP13_06685 DSBA-like thioredoxin domain-containing protein AlphaFold + ColabFold –
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.827 No Hit 0.0% —
1197 KP13_05442 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.827 No Hit 0.0% —
1198 KP13_05167 Tripeptide permease tppB tppB AlphaFold + ColabFold –
GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:1904680Enables the transfer of a peptide from one side of a membrane to the other. +912 total
0.827 Hit 23.6% 7.39e-09
1199 KP13_05135 Multidrug resistance protein mdtK mdtK AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015297Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +14 total
0.827 Hit 22.7% 7.92e-11
1200 KP13_04298 putative tyrosine-protein phosphatase AlphaFold + ColabFold
3.1.3.48
GO:0004721Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. GO:0004725Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
0.827 No Hit 0.0% —
Page of 234 · 5842 total proteins