Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1101 KP13_31849 Beta-lactamase SHV 110 Experimental + ColabFold model –
GO:0008800Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. GO:0017001The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. +14 total
No map 0.883 0.996 No Hit 0.0% —
1102 KP13_04022 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.883 No Hit 0.0% —
1103 KP13_03717 Outer membrane lipoprotein blc AlphaFold DB model + ColabFold model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0008289Binding to a lipid. GO:0006950Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
No map 0.883 0.81 Hit 32.1% 4.77e-07
1104 KP13_03559 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.883 0.983 Hit 27.5% 9.99e-30
1105 KP13_03283 Citrate synthase gltA AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. GO:0046912Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. +25 total
No map 0.883 0.696 Hit 25.1% 4.23e-23
1106 KP13_02200 Isopentenyl-diphosphate Delta-isomerase idi AlphaFold DB model + ColabFold model
5.3.3.2
GO:0004452Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate. GO:0008299The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.883 0.704 Hit 34.6% 9.72e-10
1107 KP13_01836 General secretion pathway protein C Experimental + AlphaFold DB model + ColabFold model –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0005515Binding to a protein. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. +14 total
No map 0.883 0.059 No Hit 0.0% —
1108 KP13_01828 Ferrichrome-iron receptor fhuA AlphaFold DB model + ColabFold model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015891The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015343Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). +25 total
No map 0.883 0.596 No Hit 0.0% —
1109 KP13_01635 Unsaturated rhamnogalacturonyl hydrolase Experimental + ColabFold model –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
No map 0.883 0.302 No Hit 0.0% —
1110 KP13_01312 5-deoxy-glucuronate isomerase iolB AlphaFold DB model + ColabFold model –
GO:0019310The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. GO:0008880Catalysis of the reaction: D-glucuronate = D-fructuronate. Also converts D-galacturonate to D-tagaturonate. GO:0016861Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears.
No map 0.883 0.949 No Hit 0.0% —
1111 KP13_00118 Drug resistance transporter, Bcr/CflA subfamily protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:1990961A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
No map 0.883 0.836 No Hit 0.0% —
1112 KP13_31632 Na(+)-translocating NADH-quinone reductase subunit A nqrA AlphaFold DB model + ColabFold model
7.2.1.1
GO:0016655Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.882 0.487 No Hit 0.0% —
1113 KP13_05534 Ascorbate-specific permease IIC component ulaA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.882 0.854 No Hit 0.0% —
1114 KP13_05031 Fumarate nitrate reduction regulatory protein fnr AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +58 total
No map 0.882 0.511 No Hit 0.0% —
1115 KP13_04088 Protein ddg ddg AlphaFold DB model + ColabFold model
2.3.1.242
GO:0009409Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +58 total
No map 0.882 0.737 No Hit 0.0% —
1116 KP13_03329 Hemolysin transporter protein hpmB hpmB AlphaFold DB model + ColabFold model –
GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0098046A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc). GO:0008320Enables the transfer of a protein from one side of a membrane to the other. +14 total
No map 0.882 0.689 No Hit 0.0% —
1117 KP13_02809 Undecaprenyl-diphosphatase uppP AlphaFold DB model + ColabFold model
3.6.1.27
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016311The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. GO:0050380Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate. +58 total
No map 0.882 0.843 No Hit 0.0% —
1118 KP13_02694 Acetolactate synthase isozyme 2 large subunit ilvG AlphaFold DB model + ColabFold model
2.2.1.6
GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. GO:0003984Catalysis of the reaction: H+ + 2 pyruvate = (2S)-2-acetolactate + CO2. Can also convert 2-oxobutanoate and pyruvate to (S)-2-ethyl-2-hydroxy-3-oxobutanoate. GO:0000287Binding to a magnesium (Mg) ion. +69 total
No map 0.882 0.998 Hit 35.1% 9.14e-11
1119 KP13_01428 Queuine tRNA-ribosyltransferase tgt AlphaFold DB model + ColabFold model
2.4.2.29
GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). GO:0006400The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). +14 total
No map 0.882 0.383 Hit 33.3% 4.67e-15
1120 KP13_01241 Glycosyl hydrolase 42 family protein AlphaFold DB model + ColabFold model
3.2.1.23
GO:0004565Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0009341A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species. +14 total
No map 0.882 0.479 No Hit 0.0% —
1121 KP13_00392 Class B acid phosphatase aphA AlphaFold DB model + ColabFold model –
GO:0003993Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
No map 0.882 0.338 No Hit 0.0% —
1122 KP13_00252 4-hydroxybenzoate transporter AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.882 0.727 Hit 31.7% 3.87e-06
1123 KP13_31780 hypothetical protein ColabFold model – – No map N/A 0.881 No Hit 0.0% —
1124 KP13_05053 putative transporter protein AlphaFold DB model + ColabFold model – – No map 0.881 0.413 No Hit 0.0% —
1125 KP13_04941 hypothetical protein AlphaFold DB model + ColabFold model
1.14.-.-
GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. GO:0006400The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.
No map 0.881 0.87 Hit 31.2% 4.43e-31
Page of 234 · 5842 total proteins