Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1151 KP13_02162 Small-conductance mechanosensitive channel mscS AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0008381Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. +14 total
0.834 No Hit 0.0% —
1152 KP13_02029 hypothetical protein AlphaFold + ColabFold – – 0.834 No Hit 0.0% —
1153 KP13_00323 putative phenolic acid decarboxylase padC AlphaFold + ColabFold –
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
0.834 No Hit 0.0% —
1154 KP13_00218 L-lactate permease lldP AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015129Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. GO:0015727The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. +14 total
0.834 No Hit 0.0% —
1155 KP13_00212 Protein-export protein secB secB AlphaFold + ColabFold –
GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0051082Binding to an unfolded protein. GO:0051262The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. +25 total
0.834 No Hit 0.0% —
1156 KP13_00168 putative inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.834 No Hit 0.0% —
1157 KP13_01939 Inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.833 No Hit 0.0% —
1158 KP13_01219 L-ribulose-5-phosphate 4-epimerase ulaF ulaF AlphaFold + ColabFold
5.1.3.4
GO:0008742Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016832Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. +36 total
0.833 No Hit 0.0% —
1159 KP13_32115 hypothetical protein ColabFold – – 0.832 No Hit 0.0% —
1160 KP13_04926 Ribonuclease E rne AlphaFold + ColabFold
3.1.26.12
GO:0003676Binding to a nucleic acid. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0003723Binding to an RNA molecule or a portion thereof. +1114 total
0.832 No Hit 0.0% —
1161 KP13_04773 Putative quinone oxidoreductase AlphaFold + ColabFold
1.3.1.95 1.3.1.84 1.6.5.-
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0043958Catalysis of the reaction: propanoyl-CoA + NAD+ = acryloyl-CoA + H+ + NADH. GO:0043957Catalysis of the reaction: acryloyl-CoA + NADPH + H+ = propionyl-CoA + NADP+.
0.832 Hit 29.1% 1.23e-07
1162 KP13_04438 PQQ-dependent dehydrogenase, glucose/quinate/shikimate family AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016614Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +36 total
0.832 No Hit 0.0% —
1163 KP13_01745 Trk system potassium uptake protein trkH trkH AlphaFold + ColabFold –
GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0071805A process in which a potassium ion is transported from one side of a membrane to the other. GO:0008324Enables the transfer of cation from one side of a membrane to the other. +58 total
0.832 No Hit 0.0% —
1164 KP13_01475 ImpA domain-containing protein AlphaFold + ColabFold – – 0.832 No Hit 0.0% —
1165 KP13_12882 Major facilitator superfamily transporter AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.831 No Hit 0.0% —
1166 KP13_06719 hypothetical protein AlphaFold + ColabFold – – 0.831 No Hit 0.0% —
1167 KP13_04239 putative diguanylate cyclase AlphaFold + ColabFold
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0005525Binding to GTP, guanosine triphosphate. +25 total
0.831 No Hit 0.0% —
1168 KP13_03925 hypothetical protein AlphaFold + ColabFold – – 0.831 No Hit 0.0% —
1169 KP13_00891 hypothetical protein ColabFold – – 0.831 No Hit 0.0% —
1170 KP13_06797 Plasmid recombination protein mob ColabFold –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.83 No Hit 0.0% —
1171 KP13_05520 hypothetical protein AlphaFold + ColabFold – – 0.83 No Hit 0.0% —
1172 KP13_03363 Enolase-phosphatase E1 mtnC AlphaFold + ColabFold
3.1.3.77
GO:0043874Catalysis of the reactions:5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate. GO:0000287Binding to a magnesium (Mg) ion. GO:0019509OBSOLETE. The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. +25 total
0.83 Hit 42.9% 3.32e-40
1173 KP13_02771 putative sodium: galactoside symporter AlphaFold + ColabFold –
GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
0.83 Hit 31.0% 1.51e-13
1174 KP13_02621 Glycine betaine/L-proline transport system permease protein proW proW AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +47 total
0.83 No Hit 0.0% —
1175 KP13_02368 Acyl-CoA dehydrogenase family protein AlphaFold + ColabFold –
GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0008470Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]. +14 total
0.83 No Hit 0.0% —
Page of 234 · 5842 total proteins