Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1226 KP13_02244 hypothetical protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.823 No Hit 0.0% —
1227 KP13_01409 putative lipoprotein AlphaFold + ColabFold – – 0.823 No Hit 0.0% —
1228 KP13_00623 Nitrogen regulation protein ntrB ntrB AlphaFold + ColabFold –
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). +25 total
0.823 No Hit 0.0% —
1229 KP13_32049 citrate utilization protein A AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
0.822 No Hit 0.0% —
1230 KP13_31542 HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.822 No Hit 0.0% —
1231 KP13_06688 hypothetical protein AlphaFold + ColabFold – – 0.822 No Hit 0.0% —
1232 KP13_04613 Mhp operon transcriptional activator mhpR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.822 No Hit 0.0% —
1233 KP13_04358 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.822 No Hit 0.0% —
1234 KP13_04152 hypothetical protein AlphaFold + ColabFold – – 0.822 No Hit 0.0% —
1235 KP13_03992 Conjugal transfer TraI helicase/relaxase ColabFold – – 0.822 No Hit 0.0% —
1236 KP13_03342 D-alanyl-D-alanine carboxypeptidase dacA dacA AlphaFold + ColabFold
3.4.16.4
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0009002Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. GO:0004180Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. +710 total
0.822 No Hit 0.0% —
1237 KP13_02615 Multidrug resistance protein B emrB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.822 No Hit 0.0% —
1238 KP13_00962 Anaerobic glycerol-3-phosphate dehydrogenase subunit A glpA AlphaFold + ColabFold
1.1.5.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0009331An enzyme complex that catalyzes the oxidation of sn-glycerol 3-phosphate to dihydroxyacetone phosphate, with concurrent reduction of flavin adenine dinucleotide (FAD) to FADH2. In E. coli, the complex is either a GlpA-GlpB-GlpC heterotrimer that functions in anaerobic conditions, or a GlpD homodimer that functions in aerobic conditions. +710 total
0.822 Hit 50.0% 5.53e-06
1239 KP13_00508 Entericidin B ecnB AlphaFold + ColabFold –
GO:0009636Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.822 No Hit 0.0% —
1240 KP13_31633 Phosphoheptose isomerase gmhA AlphaFold + ColabFold
5.3.1.28
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0008968Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate. GO:0097367Binding to a carbohydrate derivative. +47 total
0.821 No Hit 0.0% —
1241 KP13_05810 hypothetical protein ColabFold – – 0.821 No Hit 0.0% —
1242 KP13_05607 hypothetical protein AlphaFold + ColabFold –
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA.
0.821 No Hit 0.0% —
1243 KP13_05270 putative dehydrogenase AlphaFold + ColabFold –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.821 Hit 44.3% 1.46e-15
1244 KP13_04672 Phenylalanyl-tRNA synthetase beta chain pheT AlphaFold + ColabFold
6.1.1.20
GO:0004826Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). GO:0000049Binding to a transfer RNA. GO:0006432The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. +47 total
0.821 Hit 22.7% 5.50e-10
1245 KP13_04102 hypothetical protein ColabFold – – 0.821 No Hit 0.0% —
1246 KP13_05154 Superoxide dismutase Cu-Zn sodC AlphaFold + ColabFold
1.15.1.1
GO:0005507Binding to a copper (Cu) ion. GO:0006801The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. GO:0046872Binding to a metal ion. +14 total
0.82 Hit 30.9% 2.59e-06
1247 KP13_04130 Protein kinase-like domain-containing protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006468The process of introducing a phosphate group on to a protein. GO:0004672Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
0.82 No Hit 0.0% —
1248 KP13_03789 Wzy polymerase in cps region wzy AlphaFold + ColabFold – – 0.82 No Hit 0.0% —
1249 KP13_03607 Copper-exporting P-type ATPase A copA AlphaFold + ColabFold
7.2.2.8
GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0046872Binding to a metal ion. +1316 total
0.82 Hit 41.3% 1.09e-10
1250 KP13_02729 Endonuclease-1 endA AlphaFold + ColabFold –
GO:0004518Catalysis of the cleavage of ester linkages within nucleic acids. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.82 No Hit 0.0% —
Page of 234 · 5842 total proteins