Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1451 KP13_00275 Cellulose synthase operon protein AlphaFold + ColabFold – – 0.42 No Hit 0.0% —
1452 KP13_00276 Cellulose synthase catalytic subunit acsA AlphaFold + ColabFold
2.4.1.12
GO:0035438Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate. GO:0030244The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. GO:0016759Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1). +47 total
0.989 No Hit 0.0% —
1453 KP13_00277 Cyclic di-GMP-binding protein bcsB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006011The chemical reactions and pathways involving UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.511 No Hit 0.0% —
1454 KP13_00278 Cellulose synthase operon protein C bcsC AlphaFold + ColabFold –
GO:0030244The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515Binding to a protein. +25 total
0.793 No Hit 0.0% —
1455 KP13_00279 putative cellulose synthase operon protein D AlphaFold + ColabFold –
GO:0030244The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
0.15 No Hit 0.0% —
1456 KP13_00281 Cellulose synthase operon protein AlphaFold + ColabFold – – 0.911 No Hit 0.0% —
1457 KP13_00282 Cellulose biosynthesis protein BcsF bcsF AlphaFold + ColabFold – – 0.349 No Hit 0.0% —
1458 KP13_00283 Protein BcsE bcsE AlphaFold + ColabFold –
GO:0035438Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
0.602 No Hit 0.0% —
1459 KP13_00284 hypothetical protein AlphaFold + ColabFold – – 0.176 No Hit 0.0% —
1460 KP13_00285 Cellulose synthase operon protein AlphaFold + ColabFold – – 0.42 No Hit 0.0% —
1461 KP13_00286 Cellulose synthase catalytic subunit bcsA AlphaFold + ColabFold
2.4.1.12
GO:0035438Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016759Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1). +47 total
0.97 No Hit 0.0% —
1462 KP13_00287 Cyclic di-GMP-binding protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006011The chemical reactions and pathways involving UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.64 No Hit 0.0% —
1463 KP13_00288 Endoglucanase bcsZ AlphaFold + ColabFold
3.2.1.4
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0008810Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. +14 total
0.167 No Hit 0.0% —
1464 KP13_00292 Peptidase M16 domain-containing protein AlphaFold + ColabFold –
GO:0046872Binding to a metal ion. GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
0.499 No Hit 0.0% —
1465 KP13_00293 2-dehydro-3-deoxygluconokinase AlphaFold + ColabFold
2.7.1.45
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008673Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H+. +47 total
0.228 No Hit 0.0% —
1466 KP13_00294 hypothetical protein AlphaFold + ColabFold – – 0.208 No Hit 0.0% —
1467 KP13_00295 AsmA family protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0090313Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
0.99 No Hit 0.0% —
1468 KP13_00297 hypothetical protein AlphaFold + ColabFold – – 0.401 No Hit 0.0% —
1469 KP13_00298 Ribonuclease BN-related protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.976 No Hit 0.0% —
1470 KP13_00299 LysR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +25 total
0.722 No Hit 0.0% —
1471 KP13_00301 GCN5-related N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.478 No Hit 0.0% —
1472 KP13_00306 DNA methylase, N-6 adenine-specific protein AlphaFold + ColabFold
2.1.1.266
GO:0070475The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0003676Binding to a nucleic acid. +58 total
0.946 No Hit 0.0% —
1473 KP13_00307 Phosphatidic acid phosphatase family protein AlphaFold + ColabFold –
GO:0003993Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.837 No Hit 0.0% —
1474 KP13_00309 putative methyltransferase AlphaFold + ColabFold
2.1.1.242
GO:0008990Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine. GO:0031167The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.447 No Hit 0.0% —
1475 KP13_00311 Universal stress protein A uspA AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.448 No Hit 0.0% —
Page of 234 · 5842 total proteins