Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1551 KP13_03387 putative ABC transporter AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.767 Hit 37.1% 8.10e-10
1552 KP13_03218 Glutamate synthase [NADPH] small chain gltD AlphaFold + ColabFold
1.4.1.13
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. +36 total
0.767 Hit 30.6% 4.10e-08
1553 KP13_00836 putative epimerase AlphaFold + ColabFold –
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +14 total
0.767 No Hit 0.0% —
1554 KP13_00784 DNA topoisomerase, type IA, Zn finger domain-containing protein AlphaFold + ColabFold –
GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. GO:0003916Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. GO:0003917Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. +25 total
0.767 No Hit 0.0% —
1555 KP13_00449 Ribose 1,5-bisphosphate phosphokinase PhnN phnN AlphaFold + ColabFold
2.7.4.23
GO:0033863Catalysis of the reaction: D-ribose 1,5-diphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP + H+. GO:0006015The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
0.767 No Hit 0.0% —
1556 KP13_31567 Glucitol/sorbitol permease IIC component srlA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
0.766 No Hit 0.0% —
1557 KP13_04324 short-chain type dehydrogenase/reductase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0030497The elongation of a fatty acid chain by the sequential addition of two-carbon units.
0.766 Hit 41.3% 1.79e-06
1558 KP13_03988 Conjugal transfer protein TrhR ColabFold – – 0.766 No Hit 0.0% —
1559 KP13_02936 Ribonuclease H rnhA AlphaFold + ColabFold
3.1.26.4
GO:0003676Binding to a nucleic acid. GO:0004523Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.766 Hit 37.3% 3.12e-17
1560 KP13_02800 Zinc transporter zupT zupT AlphaFold + ColabFold –
GO:0030001The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0046873Enables the transfer of metal ions from one side of a membrane to the other. +25 total
0.766 Hit 39.8% 1.53e-08
1561 KP13_02587 putative High-affinity nickel transport protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0035444The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore. GO:0015099Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. +14 total
0.766 No Hit 0.0% —
1562 KP13_01243 putative inner membrane protein AlphaFold + ColabFold –
GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.766 No Hit 0.0% —
1563 KP13_00431 Cation/acetate symporter actP actP AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015123Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +69 total
0.766 Hit 26.2% 1.57e-07
1564 KP13_00157 Triosephosphate isomerase tpiA AlphaFold + ColabFold
5.3.1.1
GO:0004807Catalysis of the reaction: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate. GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.766 Hit 57.6% 1.74e-06
1565 KP13_05560 Phosphoglycerate transport regulatory protein pgtC pgtC AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.765 No Hit 0.0% —
1566 KP13_02883 putative glutathione S-transferase AlphaFold + ColabFold –
GO:0004364Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.765 No Hit 0.0% —
1567 KP13_02864 Ribosomal RNA large subunit methyltransferase G rlmG AlphaFold + ColabFold
2.1.1.174
GO:0031167The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003676Binding to a nucleic acid. +58 total
0.765 No Hit 0.0% —
1568 KP13_01110 Cell division protease ftsH ftsH AlphaFold + ColabFold
3.4.24.-
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0008270Binding to a zinc ion (Zn). GO:0004176Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. +69 total
0.765 Hit 58.8% 6.65e-46
1569 KP13_32063 hypothetical protein ColabFold – – 0.764 No Hit 0.0% —
1570 KP13_05278 putative amino-acid metabolite efflux pump eamA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.764 No Hit 0.0% —
1571 KP13_04828 yersiniabactin-iron ABC transporter AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.764 Hit 56.2% 2.02e-19
1572 KP13_00667 Glycogen phosphorylase glgP AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0008184Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. +14 total
0.764 Hit 58.9% 3.42e-85
1573 KP13_00362 Glucose-6-phosphate isomerase pgi AlphaFold + ColabFold
5.3.1.9
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. GO:0097367Binding to a carbohydrate derivative. +58 total
0.764 Hit 70.2% 0.00e+00
1574 KP13_00146 PTS system maltose-specific EIICB component glvC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +36 total
0.764 No Hit 0.0% —
1575 KP13_00001 HTH transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.764 No Hit 0.0% —
Page of 234 · 5842 total proteins