Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1576 KP13_00622 Glutamine synthetase glnA AlphaFold DB model + ColabFold model
6.3.1.2
GO:0004356Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. +69 total
No map 0.806 0.619 Hit 27.5% 1.80e-12
1577 KP13_05494 Acyl-CoA N-acyltransferase domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.805 0.378 No Hit 0.0% —
1578 KP13_04988 LysR family transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.805 0.226 No Hit 0.0% —
1579 KP13_04870 Sensor protein phoQ phoQ AlphaFold DB model + ColabFold model
2.7.13.3
GO:0018106The phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). +912 total
No map 0.805 0.366 No Hit 0.0% —
1580 KP13_01212 putative L-ascorbate-6-phosphate lactonase ulaG ulaG AlphaFold DB model + ColabFold model –
GO:0035460Catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate. GO:0030145Binding to a manganese ion (Mn). GO:0019854The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.
No map 0.805 0.633 No Hit 0.0% —
1581 KP13_05198 Acetyl-CoA acetyltransferase AlphaFold DB model + ColabFold model –
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0003988Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. +14 total
No map 0.804 0.626 Hit 44.4% 9.30e-13
1582 KP13_05148 Ribonuclease T rnt AlphaFold DB model + ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0004540Catalysis of the cleavage of phosphodiester bonds in chains of RNA. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
No map 0.804 0.606 No Hit 0.0% —
1583 KP13_00969 CinA-like protein AlphaFold DB model + ColabFold model – – No map 0.803 0.43 Hit 28.1% 7.07e-09
1584 KP13_00686 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0006139Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
No map 0.803 0.251 Hit 37.9% 8.37e-07
1585 KP13_00361 hypothetical protein ColabFold model – – No map N/A 0.803 No Hit 0.0% —
1586 KP13_04589 Coenzyme PQQ synthesis protein B pqqB AlphaFold DB model + ColabFold model –
GO:0018189The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed.
No map 0.802 0.083 No Hit 0.0% —
1587 KP13_03485 WD40/YVTN repeat-like domain-containing protein AlphaFold DB model + ColabFold model –
GO:0005515Binding to a protein.
No map 0.802 0.212 No Hit 0.0% —
1588 KP13_31483 30S ribosomal protein S21 rpsU AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
No map N/A 0.801 No Hit 0.0% —
1589 KP13_04358 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.801 0.822 No Hit 0.0% —
1590 KP13_03469 Sugar isomerase (SIS) domain-containing protein AlphaFold DB model + ColabFold model –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0097367Binding to a carbohydrate derivative. GO:0004360Catalysis of the reaction: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. +36 total
No map 0.801 0.178 Hit 26.0% 2.61e-09
1591 KP13_04598 taurine ABC superfamily ATP binding cassette transporter, binding protein AlphaFold DB model + ColabFold model – – No map 0.800 0.341 No Hit 0.0% —
1592 KP13_02497 putative 2-oxo-hepta-3-ene-1,7-dioic acid hydratase hpcG AlphaFold DB model + ColabFold model –
GO:0019439OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0018817Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate. +25 total
No map 0.800 0.435 No Hit 0.0% —
1593 KP13_01876 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.800 0.746 No Hit 0.0% —
1594 KP13_01558 Fumarylacetoacetate hydrolase domain-containing protein AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0018773Catalysis of the reaction: acetylpyruvate + H2O = acetate + H+ + pyruvate. GO:0046872Binding to a metal ion.
No map 0.800 0.456 Hit 46.0% 9.36e-62
1595 KP13_00807 Sigma-E factor negative regulatory protein rseA AlphaFold DB model + ColabFold model –
GO:0016989The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map N/A 0.8 No Hit 0.0% —
1596 KP13_00630 hypothetical protein ColabFold model – – No map N/A 0.8 No Hit 0.0% —
1597 KP13_00268 Periplasmic dipeptide transport protein dppA AlphaFold DB model + ColabFold model –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +25 total
No map 0.800 0.687 No Hit 0.0% —
1598 KP13_00159 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.800 0.958 No Hit 0.0% —
1599 KP13_00464 Melibiose carrier protein melB AlphaFold DB model + ColabFold model –
GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
No map 0.799 0.944 Hit 27.4% 1.04e-07
1600 KP13_04757 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.798 0.539 No Hit 0.0% —
Page of 234 · 5842 total proteins