Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5842 / 5842 proteins
No filters or custom sorting applied — click to see defaults

Scoring formula None

Sorted by Druggability (P2Rank preferred) (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1526 KP13_01537 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.817 0.608 No Hit 0.0% —
1527 KP13_05272 putative isomerase AlphaFold DB model + ColabFold model –
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.816 0.532 Hit 36.4% 1.06e-42
1528 KP13_02791 DNA topoisomerase 4 subunit B parE AlphaFold DB model + ColabFold model –
GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. +25 total
No map 0.816 0.795 Hit 24.7% 4.83e-31
1529 KP13_02533 putative transposase AlphaFold DB model + ColabFold model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map N/A 0.816 No Hit 0.0% —
1530 KP13_02478 N-acetyltransferase AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.816 0.022 No Hit 0.0% —
1531 KP13_02024 5'-nucleotidase AlphaFold DB model + ColabFold model –
GO:0008253Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
No map 0.816 0.23 Hit 30.3% 6.95e-16
1532 KP13_01527 High-affinity branched-chain amino acid transport system permease protein braE braE AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
No map 0.816 0.998 No Hit 0.0% —
1533 KP13_00616 GCN5-related N-acetyltransferase AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0006048The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. GO:0004343Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+. +25 total
No map 0.816 0.22 No Hit 0.0% —
1534 KP13_03036 CofD family protein AlphaFold DB model + ColabFold model –
GO:0043743Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008360Any process that modulates the surface configuration of a cell.
No map 0.815 0.342 No Hit 0.0% —
1535 KP13_02852 putative siderophore-interacting protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.815 0.19 No Hit 0.0% —
1536 KP13_05318 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.814 No Hit 0.0% —
1537 KP13_02632 DNA replication protein dnaC dnaC AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:1990077Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart. +36 total
No map 0.814 0.481 No Hit 0.0% —
1538 KP13_01027 USG-1 protein usg AlphaFold DB model + ColabFold model –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0046983The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. +14 total
No map 0.814 0.109 No Hit 0.0% —
1539 KP13_04636 TetR-family trancriptional regulatory protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map N/A 0.813 No Hit 0.0% —
1540 KP13_03489 putative dTDP (deoxythimodone diphosphates)-4-dehydrorhamnose 3,5-epimerase, RmlC AlphaFold DB model + ColabFold model – – No map 0.813 0.905 No Hit 0.0% —
1541 KP13_03461 RomA protein romA AlphaFold DB model + ColabFold model –
GO:0008270Binding to a zinc ion (Zn). GO:0070290Catalysis of the reaction: an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine (NAPE) + H2O = an N-acylethanolamine (NAE) + a 1,2-diacyl-sn-glycero-3-phosphate + H+.
No map 0.813 0.408 Hit 31.4% 2.75e-39
1542 KP13_03418 Transketolase domain-containing protein AlphaFold DB model + ColabFold model
2.2.1.1
GO:0004802Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor.
No map 0.812 0.426 Hit 39.4% 4.17e-15
1543 KP13_02561 putative LamB-type porin AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034219The process in which a carbohydrate is transported across a membrane. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. +58 total
No map 0.812 0.197 No Hit 0.0% —
1544 KP13_01890 putative protein transporter AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.812 0.81 No Hit 0.0% —
1545 KP13_07605 HTH-type transcriptional regulator regA regA AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.811 0.967 No Hit 0.0% —
1546 KP13_04428 Adenosine deaminase add AlphaFold DB model + ColabFold model
3.5.4.4
GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R). GO:0004000Catalysis of the reaction: adenosine + H2O = inosine + NH4+. GO:0009168The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. +710 total
No map 0.811 0.869 Hit 43.9% 5.36e-06
1547 KP13_04411 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.811 No Hit 0.0% —
1548 KP13_03769 Histidinol-phosphate aminotransferase hisC Experimental + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0004400Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. +36 total
No map 0.811 0.775 Hit 30.7% 1.30e-08
1549 KP13_03394 Carbon starvation protein A cstA AlphaFold DB model + ColabFold model –
GO:0009267Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.811 0.761 No Hit 0.0% —
1550 KP13_00623 Nitrogen regulation protein ntrB ntrB AlphaFold DB model + ColabFold model –
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). +25 total
No map 0.811 0.823 No Hit 0.0% —
Page of 234 · 5842 total proteins