Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1701 KP13_00660 Low-affinity gluconate transporter gntU AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015128Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose. GO:0035429The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose. +14 total
No map 0.888 No Hit 0.0% —
1702 KP13_00661 hypothetical protein AlphaFold + ColabFold – – No map 0.848 No Hit 0.0% —
1703 KP13_00662 Aspartate-semialdehyde dehydrogenase asd AlphaFold + ColabFold –
GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. GO:0009097OBSOLETE. The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. +811 total
No map 0.538 No Hit 0.0% —
1704 KP13_00664 Glycogen debranching enzyme glgX AlphaFold + ColabFold
3.2.1.196
GO:0005980The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. +36 total
No map 0.651 No Hit 0.0% —
1705 KP13_00666 Glycogen synthase glgA AlphaFold + ColabFold
2.4.1.21
GO:0004373Catalysis of the reaction: [(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + H+ + UDP. GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.56 No Hit 0.0% —
1706 KP13_00668 hypothetical protein AlphaFold + ColabFold – – No map 0.352 No Hit 0.0% —
1707 KP13_00669 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.651 No Hit 0.0% —
1708 KP13_00671 Thiosulfate sulfurtransferase glpE glpE AlphaFold + ColabFold
2.8.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004792Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+. GO:0103041Catalysis of the reaction: thiosulfate + [thioredoxin]-dithiol = sulfite + 2 H+ + [thioredoxin]-disulfide + hydrogen sulfide.
No map 0.405 No Hit 0.0% —
1709 KP13_00672 Rhomboid protease glpG glpG AlphaFold + ColabFold
3.4.21.105
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +14 total
No map 0.922 No Hit 0.0% —
1710 KP13_00673 Glycerol-3-phosphate regulon repressor glpR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.287 No Hit 0.0% —
1711 KP13_00674 HTH-type transcriptional regulator malT AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005515Binding to a protein. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +47 total
No map 0.239 No Hit 0.0% —
1712 KP13_00675 hypothetical protein ColabFold – – No map 0.489 No Hit 0.0% —
1713 KP13_00677 4-alpha-glucanotransferase malQ AlphaFold + ColabFold
2.4.1.25
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004134Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan.
No map 0.484 No Hit 0.0% —
1714 KP13_00678 High-affinity gluconate transporter gntT AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015128Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose. GO:0035429The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose. +14 total
No map 0.749 No Hit 0.0% —
1715 KP13_00679 Fe/S biogenesis protein nfuA nfuA AlphaFold + ColabFold –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0051604Any process leading to the attainment of the full functional capacity of a protein. GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. +25 total
No map 0.387 No Hit 0.0% —
1716 KP13_00680 Protein gntX gntX AlphaFold + ColabFold – – No map 0.673 No Hit 0.0% —
1717 KP13_00682 hypothetical protein AlphaFold + ColabFold – – No map 0.348 No Hit 0.0% —
1718 KP13_00683 Ferrous iron transport protein C feoC Experimental + AlphaFold + ColabFold – – No map 0.659 No Hit 0.0% —
1719 KP13_00684 Ferrous iron transport protein B feoB Experimental + AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015093Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.993 No Hit 0.0% —
1720 KP13_00688 Transcriptional regulatory protein ompR ompR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +58 total
No map 0.363 No Hit 0.0% —
1721 KP13_00689 Osmolarity sensor protein envZ envZ AlphaFold + ColabFold –
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
No map 0.902 No Hit 0.0% —
1722 KP13_00690 Phosphoenolpyruvate carboxykinase pckA AlphaFold + ColabFold
4.1.1.49
GO:0017076Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006094The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. +47 total
No map 0.267 No Hit 0.0% —
1723 KP13_00691 hypothetical protein AlphaFold + ColabFold – – No map 0.271 No Hit 0.0% —
1724 KP13_00692 33 kDa chaperonin hslO AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051082Binding to an unfolded protein. GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. +25 total
No map 0.294 No Hit 0.0% —
1725 KP13_00693 Heat shock protein 15 hslR AlphaFold + ColabFold –
GO:0034605Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. GO:0043023Binding to a large ribosomal subunit. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
No map 0.32 No Hit 0.0% —
Page of 234 · 5842 total proteins