Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2051 KP13_00161 Fructose-1,6-bisphosphatase class 2 glpX AlphaFold DB model + ColabFold model –
GO:0006094The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. GO:0006071The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. GO:0042132Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. +36 total
No map 0.702 0.467 No Hit 0.0% —
2052 KP13_04887 hypothetical protein ColabFold model – – No map N/A 0.701 No Hit 0.0% —
2053 KP13_04786 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0051607Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
No map 0.701 0.315 No Hit 0.0% —
2054 KP13_01897 Protein translocase subunit secA secA AlphaFold DB model + ColabFold model
7.4.2.8
GO:0006886The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006605The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. +912 total
No map 0.701 0.259 No Hit 0.0% —
2055 KP13_01724 putative HAD-superfamily hydrolase Experimental + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.701 0.325 No Hit 0.0% —
2056 KP13_00858 Nucleoside diphosphate kinase ndk AlphaFold DB model + ColabFold model
2.7.4.6
GO:0006183The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. GO:0006241The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. GO:0004550Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. +47 total
No map 0.701 0.721 Hit 51.4% 1.87e-18
2057 KP13_00569 Bifunctional aspartokinase/homoserine dehydrogenase 2 metL AlphaFold DB model + ColabFold model –
GO:0009067The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0004412Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+. +912 total
No map 0.701 0.893 No Hit 0.0% —
2058 KP13_00313 Low-affinity inorganic phosphate transporter 1 pitA AlphaFold DB model + ColabFold model –
GO:0005315Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006817The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
No map 0.701 0.913 Hit 28.4% 3.63e-08
2059 KP13_00010 Low affinity potassium transport system protein kup kup AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0071805A process in which a potassium ion is transported from one side of a membrane to the other. GO:0015079Enables the transfer of potassium ions (K+) from one side of a membrane to the other.
No map 0.701 0.644 No Hit 0.0% —
2060 KP13_31637 DNAase like-I protein AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
No map 0.700 0.178 No Hit 0.0% —
2061 KP13_05091 hypothetical protein ColabFold model – – No map N/A 0.7 No Hit 0.0% —
2062 KP13_05048 L-tartrate/succinate antiporter ttdT AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.700 0.807 Hit 22.5% 5.46e-07
2063 KP13_04695 Oligopeptide transport system permease protein oppB oppB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.700 0.642 No Hit 0.0% —
2064 KP13_03538 Inner membrane protein AlphaFold DB model + ColabFold model – – No map 0.700 0.988 No Hit 0.0% —
2065 KP13_00582 Cation-efflux pump fieF fieF AlphaFold DB model + ColabFold model –
GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0008324Enables the transfer of cation from one side of a membrane to the other. GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +1013 total
No map 0.700 0.985 Hit 23.5% 2.86e-09
2066 KP13_31809 Dephospho-CoA kinase coaE AlphaFold DB model + ColabFold model
2.7.1.24
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004140Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+. GO:0015937The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. +14 total
No map 0.699 0.48 Hit 45.9% 7.74e-25
2067 KP13_25192 3-oxoadipate enol-lactonase 2 AlphaFold DB model + ColabFold model –
GO:0047570Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate. GO:0042952A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates.
No map 0.699 0.536 Hit 29.4% 8.02e-07
2068 KP13_05615 hypothetical protein ColabFold model – – No map N/A 0.699 No Hit 0.0% —
2069 KP13_05088 Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B lpsJ AlphaFold DB model + ColabFold model –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
No map 0.699 0.415 Hit 49.8% 2.59e-69
2070 KP13_04764 hypothetical protein AlphaFold DB model + ColabFold model
2.7.7.65
GO:0005515Binding to a protein. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+.
No map 0.699 0.608 No Hit 0.0% —
2071 KP13_04378 hypothetical protein ColabFold model – – No map N/A 0.699 No Hit 0.0% —
2072 KP13_01582 Peptidoglycan synthase ftsI ftsI AlphaFold DB model + ColabFold model
3.4.16.4
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. +811 total
No map 0.699 0.202 No Hit 0.0% —
2073 KP13_05390 N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIB component chbB AlphaFold DB model + ColabFold model
2.7.1.196
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map N/A 0.698 No Hit 0.0% —
2074 KP13_05036 Indole-3-acetyl-aspartic acid hydrolase iaaH Experimental + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
No map 0.698 0.378 No Hit 0.0% —
2075 KP13_02538 hypothetical protein ColabFold model – – No map N/A 0.698 No Hit 0.0% —
Page of 234 · 5842 total proteins