Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2076 KP13_00809 Sigma-E factor regulatory protein rseC rseC AlphaFold DB model + ColabFold model – – No map N/A 0.698 No Hit 0.0% —
2077 KP13_32046 molybdopterin biosynthesis family protein AlphaFold DB model + ColabFold model
2.10.1.1
GO:0032324The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.697 0.787 Hit 43.4% 9.64e-32
2078 KP13_31938 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map N/A 0.697 No Hit 0.0% —
2079 KP13_03984 F-type conjugal transfer protein TraH ColabFold model – – No map N/A 0.697 No Hit 0.0% —
2080 KP13_03019 Formimidoylglutamase hutG AlphaFold DB model + ColabFold model
3.5.3.8
GO:0019556OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide. GO:0016813Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. GO:0046872Binding to a metal ion. +58 total
No map 0.697 0.413 Hit 23.1% 2.45e-08
2081 KP13_02953 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.697 No Hit 0.0% —
2082 KP13_01848 Type 4 prepilin-like proteins leader peptide-processing enzyme bifunctional protein pulO AlphaFold DB model + ColabFold model
2.1.1.- 3.4.23.43
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0004190Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +36 total
No map 0.697 0.133 No Hit 0.0% —
2083 KP13_31870 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.696 No Hit 0.0% —
2084 KP13_12182 Preprotein translocase subunit secE AlphaFold DB model + ColabFold model –
GO:0009306The controlled release of proteins from a cell. GO:0006886The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +58 total
No map N/A 0.696 No Hit 0.0% —
2085 KP13_03858 FMN reductase ssuE AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008752Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. This reaction can utilize NADH and NADPH with similar reaction rates. GO:0046306The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group.
No map N/A 0.696 No Hit 0.0% —
2086 KP13_03509 putative periplasmic binding protein AlphaFold DB model + ColabFold model – – No map 0.696 0.457 No Hit 0.0% —
2087 KP13_05434 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.695 0.184 No Hit 0.0% —
2088 KP13_03877 Helicase IV helD AlphaFold DB model + ColabFold model
5.6.2.4
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +58 total
No map 0.695 0.491 No Hit 0.0% —
2089 KP13_02847 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.695 No Hit 0.0% —
2090 KP13_01310 Sugar epimerase domain-containing protein AlphaFold DB model + ColabFold model –
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
No map 0.695 0.302 No Hit 0.0% —
2091 KP13_31911 hypothetical protein ColabFold model – – No map N/A 0.694 No Hit 0.0% —
2092 KP13_05261 Glutaminase glsA AlphaFold DB model + ColabFold model
3.5.1.2
GO:0004359Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH4+. GO:0006541The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. GO:0006537OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. +14 total
No map 0.694 0.895 Hit 45.3% 2.72e-22
2093 KP13_03366 hypothetical protein ColabFold model – – No map N/A 0.694 No Hit 0.0% —
2094 KP13_03101 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.694 No Hit 0.0% —
2095 KP13_02388 hypothetical protein ColabFold model – – No map N/A 0.694 No Hit 0.0% —
2096 KP13_01012 GCN5-related N-acetyltransferase AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.694 0.343 No Hit 0.0% —
2097 KP13_00309 putative methyltransferase AlphaFold DB model + ColabFold model
2.1.1.242
GO:0008990Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine. GO:0031167The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.694 0.447 No Hit 0.0% —
2098 KP13_32155 hypothetical protein ColabFold model – – No map N/A 0.693 No Hit 0.0% —
2099 KP13_04971 putative phenylacetic acid degradation NADH oxidoreductase paaE paaE AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate. +36 total
No map 0.693 0.352 Hit 26.7% 1.63e-09
2100 KP13_01173 AI-2 transport protein tqsA tqsA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.693 0.455 No Hit 0.0% —
Page of 234 · 5842 total proteins