Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2001 KP13_02757 Cystathionine beta-lyase metC AlphaFold DB model + ColabFold model –
GO:0019346The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +58 total
No map 0.712 0.519 Hit 48.6% 3.98e-111
2002 KP13_02709 alpha/beta hydrolase fold domain-containing protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.712 0.753 Hit 38.9% 1.22e-07
2003 KP13_02023 Peptide chain release factor 3 prfC AlphaFold DB model + ColabFold model –
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate. GO:0006415The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). +69 total
No map 0.712 0.289 Hit 42.9% 6.08e-07
2004 KP13_01167 Acid shock protein asr AlphaFold DB model + ColabFold model – – No map N/A 0.712 No Hit 0.0% —
2005 KP13_00029 Glucosamine--fructose-6-phosphate aminotransferase isomerizing glmS AlphaFold DB model + ColabFold model
2.6.1.16
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0097367Binding to a carbohydrate derivative. GO:0004360Catalysis of the reaction: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. +710 total
No map 0.712 0.989 Hit 40.9% 4.81e-94
2006 KP13_31931 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.711 0.87 No Hit 0.0% —
2007 KP13_02435 SsrA-binding protein smpB AlphaFold DB model + ColabFold model –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0070929A translational elongation process in which transfer of a translating ribosome from one mRNA to another RNA template takes place. Trans-translation occurs during tmRNA release of stalled ribosomes. +14 total
No map N/A 0.711 No Hit 0.0% —
2008 KP13_01968 Alanyl-tRNA editing protein alaX-M alaXM AlphaFold DB model + ColabFold model –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
No map 0.711 0.261 Hit 25.8% 6.70e-07
2009 KP13_01501 pyocin domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.711 0.162 No Hit 0.0% —
2010 KP13_00653 Gamma-glutamyltranspeptidase ggt AlphaFold DB model + ColabFold model
2.3.2.2 3.4.19.13
GO:0006751The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. GO:0036374Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. GO:0103068OBSOLETE. Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid. +14 total
No map 0.711 0.442 Hit 40.9% 2.69e-24
2011 KP13_32065 Acyl-CoA thioesterase tesA ColabFold model – – No map N/A 0.71 No Hit 0.0% —
2012 KP13_06703 Carbepenem-hydrolyzing beta-lactamase KPC2 Experimental + ColabFold model
3.5.2.6
GO:0008800Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. GO:0017001The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. +25 total
No map 0.710 0.994 No Hit 0.0% —
2013 KP13_02317 Propanediol dehydratase large subunit pduC AlphaFold DB model + ColabFold model –
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0031419Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
No map 0.710 0.451 No Hit 0.0% —
2014 KP13_18151 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.709 0.907 Hit 27.6% 5.58e-12
2015 KP13_07626 Protocatechuate 4,5-dioxygenase beta chain AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008198Binding to a ferrous iron ion, Fe(II). GO:0006725OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. +14 total
No map 0.709 0.488 No Hit 0.0% —
2016 KP13_04640 putative TetR-family trancriptional regulatory protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
No map 0.709 0.81 No Hit 0.0% —
2017 KP13_01283 Phosphotransferase system, lactose/cellobiose IIC component AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +25 total
No map 0.709 0.974 No Hit 0.0% —
2018 KP13_04813 Type IV secretion system protein virB1 virB1 AlphaFold DB model + ColabFold model – – No map 0.708 0.489 No Hit 0.0% —
2019 KP13_03089 putative transmembrane protein AlphaFold DB model + ColabFold model – – No map N/A 0.708 No Hit 0.0% —
2020 KP13_02614 2-isopropylmalate synthase AlphaFold DB model + ColabFold model
2.3.3.13
GO:0019752The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). GO:0003852Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+. GO:0009098The chemical reactions and pathways resulting in the formation of L-leucine, 2-amino-4-methylpentanoic acid. +58 total
No map 0.708 0.286 No Hit 0.0% —
2021 KP13_01764 LysR family transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.708 0.921 No Hit 0.0% —
2022 KP13_32392 hypothetical protein ColabFold model – – No map N/A 0.707 No Hit 0.0% —
2023 KP13_06797 Plasmid recombination protein mob ColabFold model –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.707 0.83 No Hit 0.0% —
2024 KP13_05471 TenA family transcription regulator AlphaFold DB model + ColabFold model
3.5.99.2
GO:0050334Catalysis of the reaction: H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H+. GO:0006772The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.707 0.648 No Hit 0.0% —
2025 KP13_04156 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.707 No Hit 0.0% —
Page of 234 · 5842 total proteins