Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2126 KP13_00162 ATP-dependent DNA helicase recG recG AlphaFold + ColabFold
5.6.2.4
GO:0003676Binding to a nucleic acid. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. +58 total
0.673 Hit 38.0% 4.92e-06
2127 KP13_02816 Urease subunit alpha ureC Experimental + ColabFold
3.5.1.5
GO:0016151Binding to a nickel (Ni) cation. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0009039Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+. +47 total
0.672 No Hit 0.0% —
2128 KP13_00897 Large terminase protein AlphaFold + ColabFold – – 0.672 No Hit 0.0% —
2129 KP13_00194 Lipopolysaccharide core biosynthesis protein rfaG rfaG AlphaFold + ColabFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:1901135The chemical reactions and pathways involving carbohydrate derivative.
0.672 No Hit 0.0% —
2130 KP13_05474 hypothetical protein AlphaFold + ColabFold –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.671 Hit 25.9% 5.37e-07
2131 KP13_03857 Putative aliphatic sulfonates-binding protein ssuA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.671 No Hit 0.0% —
2132 KP13_03513 hypothetical protein AlphaFold + ColabFold – – 0.671 No Hit 0.0% —
2133 KP13_03309 hypothetical protein AlphaFold + ColabFold – – 0.671 No Hit 0.0% —
2134 KP13_01479 type VI secretion system protein AlphaFold + ColabFold – – 0.671 No Hit 0.0% —
2135 KP13_01197 hypothetical protein ColabFold – – 0.671 No Hit 0.0% —
2136 KP13_01184 GckR family protein AlphaFold + ColabFold –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0016835Catalysis of the breakage of a carbon-oxygen bond. GO:0046348The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. +36 total
0.671 No Hit 0.0% —
2137 KP13_00886 hypothetical protein AlphaFold + ColabFold – – 0.671 No Hit 0.0% —
2138 KP13_04112 Protein nrdI nrdI AlphaFold + ColabFold –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
0.67 No Hit 0.0% —
2139 KP13_02119 branched-chain amino acid transport ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015658Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. +14 total
0.67 Hit 29.4% 7.56e-08
2140 KP13_01718 Phospholipase A1 bifunctional protein pldA AlphaFold + ColabFold
3.1.1.32 3.1.1.4
GO:0004620Catalysis of the hydrolysis of a glycerophospholipid. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. +58 total
0.67 No Hit 0.0% —
2141 KP13_07244 Bifunctional protein glmU glmU Experimental + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. +58 total
0.669 No Hit 0.0% —
2142 KP13_04272 D-alanyl-D-alanine carboxypeptidase dacC dacC AlphaFold + ColabFold
3.4.16.4
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0009002Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. GO:0004180Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. +710 total
0.669 No Hit 0.0% —
2143 KP13_03441 putative binding-protein-dependent transport system protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +25 total
0.669 No Hit 0.0% —
2144 KP13_02737 hypothetical protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.669 No Hit 0.0% —
2145 KP13_02416 Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive aroF AlphaFold + ColabFold
2.5.1.54
GO:0003849Catalysis of the reaction: D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0009073The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). +47 total
0.669 No Hit 0.0% —
2146 KP13_02135 Phosphonate transport system permease protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015416Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). GO:0015716The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). +25 total
0.669 No Hit 0.0% —
2147 KP13_01675 hypothetical protein AlphaFold + ColabFold – – 0.669 No Hit 0.0% —
2148 KP13_01034 hypothetical protein AlphaFold + ColabFold – – 0.669 No Hit 0.0% —
2149 KP13_00698 hypothetical protein AlphaFold + ColabFold – – 0.669 No Hit 0.0% —
2150 KP13_13347 Uridine phosphorylase udp AlphaFold + ColabFold
2.4.2.3
GO:0009166The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). GO:0009116The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +69 total
0.668 Hit 30.4% 3.22e-09
Page of 234 · 5842 total proteins