Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2326 KP13_01574 putative inner membrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.991 No Hit 0.0% —
2327 KP13_01575 PTS system mannose-specific EIIAB component manX AlphaFold + ColabFold
2.7.1.191
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +58 total
No map 0.499 No Hit 0.0% —
2328 KP13_01576 Mannose permease IIC component manY AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.971 No Hit 0.0% —
2329 KP13_01577 Mannose permease IID component manZ AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.549 No Hit 0.0% —
2330 KP13_01579 hypothetical protein AlphaFold + ColabFold – – No map 0.304 No Hit 0.0% —
2331 KP13_01580 putative inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005384Enables the transfer of manganese (Mn) ions from one side of a membrane to the other.
No map 0.463 No Hit 0.0% —
2332 KP13_01581 Ribosomal RNA large subunit methyltransferase A rlmA ColabFold –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule.
No map 0.852 No Hit 0.0% —
2333 KP13_01582 Peptidoglycan synthase ftsI ftsI AlphaFold + ColabFold
3.4.16.4
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. +811 total
No map 0.202 No Hit 0.0% —
2334 KP13_01584 hypothetical protein ColabFold – – No map 0.934 No Hit 0.0% —
2335 KP13_01585 putative transposase AlphaFold + ColabFold – – No map 0.074 No Hit 0.0% —
2336 KP13_01586 hypothetical protein AlphaFold + ColabFold – – No map 0.343 No Hit 0.0% —
2337 KP13_01587 Transcriptional regulator kdgR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.971 No Hit 0.0% —
2338 KP13_01589 Protease htpX htpX AlphaFold + ColabFold
3.4.24.-
GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.678 No Hit 0.0% —
2339 KP13_01590 Tail-specific protease prc AlphaFold + ColabFold
3.4.21.102
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005515Binding to a protein. GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +47 total
No map 0.168 No Hit 0.0% —
2340 KP13_01591 ProP effector proQ AlphaFold + ColabFold –
GO:0034057Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity. GO:0010608Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. GO:0033592An activity that facilitates the formation of a complementary double-stranded RNA molecule. +25 total
No map 0.378 No Hit 0.0% —
2341 KP13_01592 GAF domain-containing protein AlphaFold + ColabFold –
GO:0005515Binding to a protein. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0033745Catalysis of the reaction: [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol.
No map 0.42 No Hit 0.0% —
2342 KP13_01593 Inner membrane protein AlphaFold + ColabFold – – No map 0.702 No Hit 0.0% —
2343 KP13_01597 hypothetical protein AlphaFold + ColabFold – – No map 0.378 No Hit 0.0% —
2344 KP13_01598 Serine/threonine-protein phosphatase 1 AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.272 No Hit 0.0% —
2345 KP13_01599 hypothetical protein AlphaFold + ColabFold –
GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
No map 0.858 No Hit 0.0% —
2346 KP13_01600 hypothetical protein AlphaFold + ColabFold – – No map 0.455 No Hit 0.0% —
2347 KP13_01601 Copper resistance protein D AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006825The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.991 No Hit 0.0% —
2348 KP13_01604 Exodeoxyribonuclease 10 exoX AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. +14 total
No map 0.447 No Hit 0.0% —
2349 KP13_01606 Inner membrane protein AlphaFold + ColabFold – – No map 0.989 No Hit 0.0% —
2350 KP13_01607 YebG family protein AlphaFold + ColabFold – – No map 0.349 No Hit 0.0% —
Page of 234 · 5842 total proteins