Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2501 PA3157 acetyltransferase PA3157 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). +25 total
0.758 No Hit N/A —
2502 PA2876 orotidine 5'-phosphate decarboxylase PA2876, pyrF AlphaFold
4.1.1.23
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004590Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP. GO:0006207The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. +14 total
0.758 No Hit N/A —
2503 PA2704 transcriptional regulator PA2704 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.758 No Hit N/A —
2504 PA1537 Baeyer-Villiger monooxygenase PA1537 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.758 Hit 45.8% 1.33e-09
2505 PA1438 two-component sensor PA1438 AlphaFold
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. +69 total
0.758 No Hit N/A —
2506 PA1265 hypothetical protein PA1265 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.758 No Hit N/A —
2507 PA1052a hypothetical protein ColabFold – – 0.758 No Hit N/A —
2508 PA0920 hypothetical protein PA0920 Experimental + AlphaFold
2.3.2.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0047637Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala). GO:0050071Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys). +36 total
0.758 No Hit N/A —
2509 PA0638 bacteriophage protein PA0638 AlphaFold –
GO:0030430The cytoplasm of a host cell. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0046718The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell. +14 total
0.758 No Hit N/A —
2510 PA0426 multidrug resistance protein MexB PA0426, mexB Experimental + AlphaFold –
GO:1990281A protein complex that is capable of efflux transmembrane transporter activity. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. +710 total
0.758 No Hit N/A —
2511 PA0113 protoheme IX farnesyltransferase cyoE1, PA0113 AlphaFold
2.5.1.141
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008495Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate. GO:0006783The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. +36 total
0.758 Hit 38.2% 2.70e-23
2512 PA5271 hypothetical protein PA5271 AlphaFold – – 0.757 No Hit N/A —
2513 PA3510 hypothetical protein PA3510 AlphaFold – – 0.757 No Hit N/A —
2514 PA3262 FkbP-type peptidyl-prolyl cis-trans isomerase PA3262 Experimental + AlphaFold
5.2.1.8
GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
0.757 Hit 44.9% 1.14e-18
2515 PA2941 hypothetical protein PA2941 AlphaFold – – 0.757 No Hit N/A —
2516 PA2609 hypothetical protein PA2609 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004645Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. GO:0009032Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. +14 total
0.757 No Hit N/A —
2517 PA2583 sensor/response regulator hybrid protein PA2583 AlphaFold
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009927Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator. +58 total
0.757 No Hit N/A —
2518 PA2483 hypothetical protein PA2483 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
0.757 No Hit N/A —
2519 PA1714 hypothetical protein PA1714, exsD AlphaFold –
GO:0071277Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0050709Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
0.757 No Hit N/A —
2520 PA0695 hypothetical protein PA0695 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.757 No Hit N/A —
2521 PA0421 hypothetical protein PA0421 AlphaFold
1.13.12.3
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0050361Catalysis of the reaction: L-tryptophan + O2 = CO2 + H2O + indole-3-acetamide. GO:0009851The chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth.
0.757 Hit 29.1% 4.55e-12
2522 PA0090 secretion protein ClpV1 PA0090, clpV1 Experimental + AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +14 total
0.757 Hit 42.8% 2.00e-37
2523 PA5441 hypothetical protein PA5441 AlphaFold – – 0.756 No Hit N/A —
2524 PA4706 hemin importer ATP-binding subunit PA4706, hmuV, phuV AlphaFold
7.6.2.-
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.756 Hit 40.6% 8.45e-06
2525 PA4612 hypothetical protein PA4612 AlphaFold –
GO:0005515Binding to a protein.
0.756 Hit 41.7% 6.00e-06
Page of 223 · 5572 total proteins