Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3401 PA2955 hypothetical protein PA2955 AlphaFold – – No map 0.679 No Hit N/A —
3402 PA2596 hypothetical protein PA2596 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
No map 0.679 No Hit N/A —
3403 PA1926 hypothetical protein PA1926 AlphaFold – – No map 0.679 No Hit N/A —
3404 PA1914 hypothetical protein PA1914 AlphaFold – – No map 0.679 No Hit N/A —
3405 PA1841 hypothetical protein PA1841 AlphaFold –
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA.
No map 0.679 Hit 34.2% 9.28e-21
3406 PA1752 2-dehydropantoate 2-reductase PA1752 Experimental + AlphaFold
1.1.1.169
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008677Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + H+ + NADPH. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +25 total
No map 0.679 No Hit N/A —
3407 PA1164 hypothetical protein PA1164 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0061503Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A. +25 total
No map 0.679 Hit 34.2% 3.34e-09
3408 PA0784 transcriptional regulator PA0784 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template. +25 total
No map 0.679 No Hit N/A —
3409 PA4664 methyl transferase prmC, PA4664, hemK AlphaFold
2.1.1.297
GO:0003676Binding to a nucleic acid. GO:0102559Catalysis of the reaction: L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H+. GO:0036009Catalysis of the reaction: L-glutaminyl-[protein] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine + H+. +58 total
No map 0.678 Hit 32.8% 4.33e-23
3410 PA3137 major facilitator superfamily transporter PA3137 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.678 No Hit N/A —
3411 PA2715 ferredoxin PA2715 AlphaFold –
GO:0051538Binding to a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. +14 total
No map 0.678 No Hit N/A —
3412 PA2594 hypothetical protein PA2594 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
No map 0.678 No Hit N/A —
3413 PA0406 transporter TonB tonB3, PA0406 AlphaFold –
GO:0098797Any protein complex that is part of the plasma membrane. GO:0031992The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell. GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.678 No Hit N/A —
3414 PA3341 transcriptional regulator PA3341 Experimental + AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0046872Binding to a metal ion. +25 total
No map 0.677 No Hit N/A —
3415 PA3231 hypothetical protein PA3231 AlphaFold – – No map 0.677 No Hit N/A —
3416 PA2143 hypothetical protein PA2143 AlphaFold – – No map 0.677 No Hit N/A —
3417 PA1906 hypothetical protein PA1906 AlphaFold – – No map 0.677 No Hit N/A —
3418 PA1229 transcriptional regulator PA1229 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +25 total
No map 0.677 No Hit N/A —
3419 PA0754 hypothetical protein PA0754 AlphaFold – – No map 0.677 No Hit N/A —
3420 PA0456 cold-shock protein PA0456 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003676Binding to a nucleic acid. GO:0010468Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
No map 0.677 Hit 46.2% 3.33e-10
3421 PA5245 glutamine amidotransferase PA5245 AlphaFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
No map 0.676 Hit 57.1% 1.29e-35
3422 PA5007 hypothetical protein PA5007 AlphaFold –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
No map 0.676 No Hit N/A —
3423 PA3729 hypothetical protein PA3729 AlphaFold –
GO:0012505A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.676 No Hit N/A —
3424 PA2793 hypothetical protein PA2793 AlphaFold – – No map 0.676 No Hit N/A —
3425 PA2600 hypothetical protein PA2600 AlphaFold –
GO:0008726Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN. GO:0046306The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group. GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
No map 0.676 No Hit N/A —
Page of 223 · 5572 total proteins