Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
326 PA0138 ABC transporter permease PA0138 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.939 No Hit N/A —
327 PA4460 hypothetical protein PA4460, lptH, lptA Experimental + AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0017089Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid. +47 total
0.938 No Hit N/A —
328 PA4040 hypothetical protein PA4040 AlphaFold – – 0.938 No Hit N/A —
329 PA4018 hypothetical protein PA4018 AlphaFold – – 0.938 No Hit N/A —
330 PA3740 hypothetical protein PA3740 AlphaFold – – 0.938 No Hit N/A —
331 PA3464 hypothetical protein PA3464 AlphaFold –
GO:0016788Catalysis of the hydrolysis of any ester bond.
0.938 No Hit N/A —
332 PA3355 hypothetical protein PA3355 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.938 No Hit N/A —
333 PA3325 hypothetical protein PA3325 AlphaFold – – 0.938 No Hit N/A —
334 PA2916 hypothetical protein PA2916 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015171Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. GO:0033228The directed movement of cysteine from inside of a cell, across the plasma membrane and into the extracellular region. +25 total
0.938 No Hit N/A —
335 PA2779 hypothetical protein PA2779 AlphaFold – – 0.938 No Hit N/A —
336 PA2028 transcriptional regulator PA2028 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.938 No Hit N/A —
337 PA1952 hypothetical protein PA1952, fapE AlphaFold –
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:1990000The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins. +14 total
0.938 No Hit N/A —
338 PA1633 potassium-transporting ATPase subunit A kdpA, PA1633 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008556Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). GO:0030955Binding to a potassium ion (K+). +25 total
0.938 No Hit N/A —
339 PA1594 hypothetical protein PA1594 AlphaFold –
GO:0016790Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.
0.938 No Hit N/A —
340 PA1533 nucleoid-associated protein PA1533 AlphaFold –
GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.938 No Hit N/A —
341 PA1007 hypothetical protein PA1007 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.938 No Hit N/A —
342 PA0809 divalent metal cation transporter MntH PA0809, mntH2 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005384Enables the transfer of manganese (Mn) ions from one side of a membrane to the other. GO:0046872Binding to a metal ion. +811 total
0.938 Hit 48.0% 9.12e-09
343 PA4455 ABC transporter permease PA4455 AlphaFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005548OBSOLETE. Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. +25 total
0.937 No Hit N/A —
344 PA4325 hypothetical protein PA4325 AlphaFold – – 0.937 No Hit N/A —
345 PA3647 hypothetical protein PA3647 AlphaFold –
GO:0051082Binding to an unfolded protein. GO:0050821Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
0.937 No Hit N/A —
346 PA1883 NADH-quinone oxidoreductase subunit A nuoA1, PA1883 AlphaFold
7.1.1.-
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0045271Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex. GO:0050136Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. +36 total
0.937 No Hit N/A —
347 PA1691 translocation protein in type III secretion PA1691, pscT AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006605The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.937 No Hit N/A —
348 PA1674 GTP cyclohydrolase I folE2, PA1674 AlphaFold
3.5.4.16
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005525Binding to GTP, guanosine triphosphate. GO:0003934Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+. +47 total
0.937 Hit 56.7% 9.57e-79
349 PA1369 hypothetical protein PA1369 AlphaFold – – 0.937 No Hit N/A —
350 PA4532 hypothetical protein PA4532 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0000041The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.936 No Hit N/A —
Page of 223 · 5572 total proteins