Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4551 PA1931 ferredoxin PA1931 AlphaFold –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion. GO:0016903Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. +25 total
0.506 Hit 38.7% 1.21e-14
4552 PA1365 siderophore receptor PA1365 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015344Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). GO:0038023Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. +47 total
0.506 No Hit N/A —
4553 PA1300 ECF subfamily sigma-70 factor PA1300 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0016987Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. +47 total
0.506 No Hit N/A —
4554 PA0189 porin PA0189 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
0.506 No Hit N/A —
4555 PA0183 arylsulfatase PA0183, atsA Experimental + AlphaFold
3.1.6.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004065Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. GO:0046872Binding to a metal ion. +25 total
0.506 Hit 48.4% 3.89e-09
4556 PA4565 gamma-glutamyl kinase proB, PA4565 AlphaFold
2.7.2.11
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004349Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H+. +58 total
0.505 Hit 34.0% 4.17e-34
4557 PA3344 ATP-dependent DNA helicase RecQ PA3344, recQ AlphaFold
5.6.2.4
GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +1619 total
0.505 Hit 48.9% 6.46e-07
4558 PA2127 hypothetical protein PA2127 AlphaFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0071453Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.
0.505 No Hit N/A —
4559 PA1292 3-mercaptopyruvate sulfurtransferase PA1292, sseA AlphaFold
2.8.1.2
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016784Catalysis of the reaction: 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H+. Note that 2-oxo-3-sulfanylpropanoate is also known as 3-mercaptopyruvate. GO:0004792Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+. +14 total
0.505 Hit 35.8% 3.42e-33
4560 PA0835 phosphate acetyltransferase PA0835, pta AlphaFold
2.3.1.8
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0008959Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate. +25 total
0.505 No Hit N/A —
4561 PA1008 bacterioferritin comigratory protein bcp, PA1008 AlphaFold
1.11.1.24
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008379Catalysis of the reaction: [thioredoxin]-dithiol + H2O2 = [thioredoxin]-disulfide + H2O. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell. +36 total
0.504 Hit 47.4% 5.95e-12
4562 PA0893 transcriptional regulator ArgR cdhR_3, argR, PA0893 AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0001216A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. GO:0001217A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. +710 total
0.504 No Hit N/A —
4563 PA0747 aldehyde dehydrogenase PA0747 AlphaFold
1.2.1.27
GO:0004491Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + hydrogencarbonate + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product. GO:0006574The chemical reactions and pathways resulting in the breakdown of L-valine. GO:0006210The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base. +25 total
0.504 Hit 58.8% 1.64e-100
4564 PA0629 hypothetical protein PA0629, lys Experimental + AlphaFold – – 0.504 No Hit N/A —
4565 PA0591 protein ApaG PA0591, apaG AlphaFold –
GO:0070987The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.
0.504 Hit 45.2% 3.37e-13
4566 PA0036 tryptophan synthase subunit beta PA0036, trpB AlphaFold
4.2.1.20
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004834Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. GO:0000162The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate. +14 total
0.504 No Hit N/A —
4567 PA4939 ATP phosphoribosyltransferase hisZ, PA4939 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004821Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). GO:0003723Binding to an RNA molecule or a portion thereof. +25 total
0.503 Hit 24.4% 3.87e-11
4568 PA4184 transcriptional regulator PA4184 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.503 Hit 24.0% 4.39e-06
4569 PA4019 aromatic acid decarboxylase PA4019, ubiX Experimental + AlphaFold
2.5.1.129
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0106141Catalysis of the reaction: dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2. GO:0004659Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). +14 total
0.503 No Hit N/A —
4570 PA2804 hypothetical protein PA2804 AlphaFold – – 0.503 No Hit N/A —
4571 PA2612 serine--tRNA ligase serS, PA2612 Experimental + AlphaFold
6.1.1.11
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004828Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). Also catalyzes the formation of L-seryl-tRNA(Sec) from tRNA(Sec), the special tRNA for selenocysteine. +58 total
0.503 Hit 37.9% 1.76e-23
4572 PA1252 bifunctional Delta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2- carboxylate reductase lhpH, lhpD, PA1252 AlphaFold
1.5.1.21 1.5.1.-
GO:0047125Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta1-piperideine-2-carboxylate. GO:0042802Binding to an identical protein or proteins. GO:0070401Binding to the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. +58 total
0.503 No Hit N/A —
4573 PA0589 thiosulfate sulfurtransferase PA0589, glpE AlphaFold
2.8.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004792Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+. GO:0103041Catalysis of the reaction: thiosulfate + [thioredoxin]-dithiol = sulfite + 2 H+ + [thioredoxin]-disulfide + hydrogen sulfide. +14 total
0.503 No Hit N/A —
4574 PA0569 hypothetical protein PA0569 AlphaFold – – 0.503 No Hit N/A —
4575 PA4928 hypothetical protein PA4928 AlphaFold –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005506Binding to an iron (Fe) ion. +14 total
0.502 No Hit N/A —
Page of 223 · 5572 total proteins