Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4526 PA2328 hypothetical protein PA2328 AlphaFold –
GO:0012505A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. GO:0009970Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate.
0.511 No Hit N/A —
4527 PA1933 hydroxylase large subunit PA1933 AlphaFold –
GO:0005506Binding to an iron (Fe) ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.511 Hit 24.2% 6.77e-29
4528 PA1496 potassium channel PA1496 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008076A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. GO:0005249Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. +58 total
0.511 Hit 46.2% 5.01e-07
4529 PA2818 aminoglycoside response regulator arr, PA2818 AlphaFold
3.1.4.52
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004114Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+. +25 total
0.51 No Hit N/A —
4530 PA1877 secretion protein PA1877 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.51 No Hit N/A —
4531 PA4462 RNA polymerase factor sigma-54 PA4462, rpoN AlphaFold –
GO:0000428A protein complex that possesses DNA-directed RNA polymerase activity. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0001216A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. +710 total
0.509 No Hit N/A —
4532 PA3807 nucleoside diphosphate kinase PA3807, ndk AlphaFold
2.7.4.6
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. +710 total
0.509 Hit 51.4% 7.40e-20
4533 PA3408 heme uptake outer membrane receptor HasR PA3408, hasR AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +811 total
0.509 No Hit N/A —
4534 PA1490 transcriptional regulator PA1490 AlphaFold –
GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0098531A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.509 No Hit N/A —
4535 PA0851 hypothetical protein PA0851 AlphaFold –
GO:0003941Catalysis of the reaction: L-serine = pyruvate + NH4+. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006565The chemical reactions and pathways resulting in the breakdown of L-serine. +14 total
0.509 Hit 32.7% 5.12e-08
4536 PA4482 aspartyl/glutamyl-tRNA amidotransferase subunit C PA4482, gatC Experimental + AlphaFold
6.3.5.-
GO:0050566Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0050567Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP. +36 total
0.508 No Hit N/A —
4537 PA3931 hypothetical protein PA3931 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.508 No Hit N/A —
4538 PA3056 hypothetical protein PA3056 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.508 No Hit N/A —
4539 PA1725 type III secretion system protein pscL, PA1725 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0030254The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.
0.508 No Hit N/A —
4540 PA1697 type III secretion system ATPase PA1697 AlphaFold
7.4.2.8
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0045259A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. GO:0030257A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase. +1013 total
0.508 Hit 37.3% 2.83e-06
4541 PA1688 hypothetical protein PA1688 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.508 No Hit N/A —
4542 PA1084 flagellar basal body P-ring protein flgI, PA1084 AlphaFold –
GO:0009428One of the rings of the bacterial-type flagellar basal body; anchors the basal body to the peptidoglycan layer. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0005198The action of a molecule that contributes to the structural integrity of a complex. +14 total
0.508 No Hit N/A —
4543 PA0987 hypothetical protein PA0987 AlphaFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.508 No Hit N/A —
4544 PA0227 CoA transferase subunit B PA0227 AlphaFold
2.8.3.6
GO:0047569Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA. GO:0042952A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates. GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
0.508 No Hit N/A —
4545 PA3875 respiratory nitrate reductase subunit alpha PA3875, narG AlphaFold
1.7.5.1
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009325An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +912 total
0.507 No Hit N/A —
4546 PA1813 hydroxyacylglutathione hydrolase PA1813, gloB Experimental + AlphaFold
3.1.2.6
GO:0004416Catalysis of the reaction: an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H+. GO:0046872Binding to a metal ion. GO:0019243OBSOLETE. The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into pyruvate via the intermediate (R)-S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.
0.507 Hit 40.9% 1.48e-20
4547 PA0098 3-oxoacyl-ACP synthase PA0098 AlphaFold –
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
0.507 No Hit N/A —
4548 PA3814 cysteine desulfurase PA3814, iscS AlphaFold
2.8.1.7
GO:1990221A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0031071Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. +47 total
0.506 Hit 72.0% 6.49e-31
4549 PA3114 tRNA pseudouridine synthase A PA3114, hisT, truA AlphaFold
5.4.99.12
GO:0009982Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0160147Catalysis of the reaction: uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA. Modifies uridine(38), uridine(39) and/or uridine(40) in tRNA. +36 total
0.506 Hit 32.5% 1.44e-09
4550 PA3112 acetyl-CoA carboxylase carboxyltransferase subunit beta accD, PA3112 AlphaFold
2.1.3.15
GO:0009329A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA. GO:0003989Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +69 total
0.506 Hit 29.1% 2.94e-06
Page of 223 · 5572 total proteins