Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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701 proteins Structure: Experimental

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Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
26 PA0523 nitric oxide reductase subunit C norC, PA0523 Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +14 total
0.943 No Hit N/A —
27 PA1526 transcriptional regulator PA1526 Experimental + AlphaFold –
GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.942 No Hit N/A —
28 PA0810 haloacid dehalogenase PA0810 Experimental + AlphaFold –
GO:0019120Catalysis of the hydrolysis of any halide bond in substances containing halogen atoms in organic linkage. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.
0.942 No Hit N/A —
29 PA5009 lipopolysaccharide kinase WaaP waaP, PA5009, rfaP Experimental + AlphaFold
2.7.1.235 2.7.10.2
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +36 total
0.941 No Hit N/A —
30 PA2465 hypothetical protein PA2465 Experimental + AlphaFold –
GO:0046872Binding to a metal ion.
0.941 No Hit N/A —
31 PA1934 hypothetical protein PA1934 Experimental + AlphaFold – – 0.941 No Hit N/A —
32 PA4460 hypothetical protein lptH, lptA, PA4460 Experimental + AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0017089Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid. +47 total
0.938 No Hit N/A —
33 PA0002 DNA polymerase III subunit beta PA0002, dnaN Experimental + AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009360The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. +58 total
0.936 No Hit N/A —
34 PA2218 hypothetical protein PA2218 Experimental + AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.935 No Hit N/A —
35 PA0083 hypothetical protein PA0083, tssB1 Experimental + AlphaFold – – 0.935 No Hit N/A —
36 PA0078 hypothetical protein PA0078 Experimental + AlphaFold –
GO:0120101A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. GO:0071973Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
0.934 No Hit N/A —
37 PA2120 hypothetical protein PA2120 Experimental + AlphaFold – – 0.933 No Hit N/A —
38 PA0999 3-oxoacyl-ACP synthase pqsD, PA0999 Experimental + AlphaFold
2.3.1.262
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). +47 total
0.931 No Hit N/A —
39 PA3385 alginate and motility regulator Z PA3385, amrZ Experimental + AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0001217A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. +1114 total
0.93 No Hit N/A —
40 PA0971 translocation protein TolA PA0971, tolA Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0019534Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. GO:0043213The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain. +25 total
0.929 No Hit N/A —
41 PA0763 sigma factor AlgU negative regulator MucA PA0763, mucA Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016989The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity. GO:0042121The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). +14 total
0.928 No Hit N/A —
42 PA4559 lipoprotein signal peptidase ls, PA4559, lspA Experimental + AlphaFold
3.4.23.36
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004190Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. GO:0004175Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. +36 total
0.927 No Hit N/A —
43 PA5134 carboxyl-terminal protease PA5134 Experimental + AlphaFold –
GO:0030313An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +1013 total
0.926 No Hit N/A —
44 PA3574 transcriptional regulator PA3574, nalD Experimental + AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. +47 total
0.926 No Hit N/A —
45 PA3096 type II secretion system protein L PA3096, xcpY Experimental + AlphaFold –
GO:0009276The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. +14 total
0.926 No Hit N/A —
46 PA4890 transcriptional regulator PA4890, desT Experimental + AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0001217A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. +36 total
0.924 No Hit N/A —
47 PA3487 phospholipase D PA3487, pldA Experimental + AlphaFold –
GO:0046872Binding to a metal ion. GO:0004630A glycerophospholipase activity that cleaves the second phosphodiester bond between the phosphate and phospholipid, releasing a phosphatidic acid. GO:0009395The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. +14 total
0.924 Hit 38.7% 6.18e-27
48 PA3859 carboxylesterase PA3859 Experimental + AlphaFold –
GO:0052689Catalysis of the hydrolysis of a carboxylic ester bond. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.923 Hit 48.8% 4.07e-18
49 PA0259 hypothetical protein PA0259, tla3 Experimental + AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0042802Binding to an identical protein or proteins.
0.923 No Hit N/A —
50 PA0218 transcriptional regulator PA0218 Experimental + AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.923 No Hit N/A —
Page of 29 · 701 total proteins