Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5426 PA4335 hypothetical protein PA4335 AlphaFold – – No pocket No Hit N/A —
5427 PA3483 hypothetical protein PA3483 AlphaFold – – No pocket No Hit N/A —
5428 PA4608 hypothetical protein PA4608 Experimental + AlphaFold –
GO:0035438Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
No pocket No Hit N/A —
5429 PA2021 hypothetical protein PA2021 AlphaFold – – No pocket No Hit N/A —
5430 PA0034 two-component response regulator PA0034 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +25 total
No pocket No Hit N/A —
5431 PA4216 pyridoxamine 5'-phosphate oxidase PA4216, phzG1 AlphaFold –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0004733Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + H2O2. This activity can also oxidize pyridoxine 5'-phosphate to pyridoxal 5'-phosphate + H2O2. GO:0002047The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring. +36 total
No pocket Hit 33.8% 2.25e-26
5432 PA3904 hypothetical protein PA3904 AlphaFold – – No pocket No Hit N/A —
5433 PA2149 hypothetical protein PA2149 AlphaFold – – No pocket No Hit N/A —
5434 PA4451 hypothetical protein PA4451 AlphaFold – – No pocket No Hit N/A —
5435 PA5276 lipopeptide LppL PA5276, lppL AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
No pocket No Hit N/A —
5436 PA4291 hypothetical protein PA4291 AlphaFold – – No pocket No Hit N/A —
5437 PA0452 hypothetical protein PA0452 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0098552A cellular component consisting of one leaflet of a membrane bilayer and any protein embedded or anchored in it or attached to its surface. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No pocket Hit 45.9% 6.31e-67
5438 PA5482 hypothetical protein PA5482 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No pocket No Hit N/A —
5439 PA1925 hypothetical protein PA1925 AlphaFold – – No pocket No Hit N/A —
5440 PA0649 anthranilate synthase component II PA0649, trpG AlphaFold
4.1.3.27
GO:0046820Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate. GO:0004049Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. GO:0000162The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate. +14 total
No pocket Hit 28.8% 7.82e-07
5441 PA0041 hemagglutinin PA0041 UnavailableNo structure available — sequence may exceed the prediction length limit –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
No structure No structure No structure No structure
5442 PA0046 hypothetical protein PA0046 AlphaFold – – No pocket No Hit N/A —
5443 PA3229 hypothetical protein PA3229 Experimental + AlphaFold – – No pocket No Hit N/A —
5444 PA3846 hypothetical protein PA3846 AlphaFold – – No pocket Hit 42.2% 3.08e-26
5445 PA3635 enolase PA3635, eno AlphaFold
4.2.1.11
GO:0009986The external part of the cell wall and/or plasma membrane. GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0000015A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. +36 total
No pocket Hit 64.1% 4.66e-48
5446 PA5195 heat shock protein PA5195 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0043023Binding to a large ribosomal subunit. GO:0003727Binding to single-stranded RNA. +25 total
No pocket No Hit N/A —
5447 PA4205 hypothetical protein mexG, PA4205 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No pocket No Hit N/A —
5448 PA0409 twitching motility protein PilH pilH, PA0409 AlphaFold –
GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
No pocket No Hit N/A —
5449 PA2569 hypothetical protein PA2569 AlphaFold – – No pocket No Hit N/A —
5450 PA2172 hypothetical protein PA2172 AlphaFold –
GO:0046872Binding to a metal ion. GO:0070006Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
No pocket No Hit N/A —
Page of 223 · 5572 total proteins