Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5451 PA5105 histidine utilization repressor HutC PA5105, hutC AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0019556OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide. +47 total
No pocket No Hit N/A —
5452 PA4134 hypothetical protein PA4134 AlphaFold – – No pocket No Hit N/A —
5453 PA3756 hypothetical protein PA3756 AlphaFold –
GO:0004180Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. GO:0008234Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. GO:0004175Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. +58 total
No pocket No Hit N/A —
5454 PA1332 hypothetical protein PA1332 AlphaFold – – No pocket No Hit N/A —
5455 PA0039 hypothetical protein PA0039 AlphaFold – – No pocket No Hit N/A —
5456 PA1743 hypothetical protein PA1743 AlphaFold – – No pocket No Hit N/A —
5457 PA4741 30S ribosomal protein S15 rpsO, PA4741 AlphaFold –
GO:0022627The small subunit of a ribosome located in the cytosol. GO:0019843Binding to a ribosomal RNA. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +25 total
No pocket No Hit N/A —
5458 PA0630 hypothetical protein PA0630 AlphaFold – – No pocket No Hit N/A —
5459 PA1100 flagellar hook-basal body complex protein FliE fliE, PA1100 AlphaFold –
GO:0009425One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. GO:0003774Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). GO:0005198The action of a molecule that contributes to the structural integrity of a complex. +36 total
No pocket No Hit N/A —
5460 PA3530 hypothetical protein bfd, PA3530 Experimental + AlphaFold –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion.
No pocket No Hit N/A —
5461 PA4242 50S ribosomal protein L36 PA4242, rpmJ AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990904A macromolecular complex that contains both RNA and protein molecules. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +25 total
No pocket No Hit N/A —
5462 PA1424a hypothetical protein ColabFold – – No pocket No Hit N/A —
5463 PA0986 hypothetical protein PA0986 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
No pocket No Hit N/A —
5464 PA3808 hypothetical protein PA3808 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008198Binding to a ferrous iron ion, Fe(II). GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
No pocket No Hit N/A —
5465 PA5226 hypothetical protein PA5226 AlphaFold – – No pocket No Hit N/A —
5466 PA3998 hypothetical protein PA3998 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No pocket No Hit N/A —
5467 PA0553 hypothetical protein PA0553 AlphaFold – – No pocket No Hit N/A —
5468 PA3033 hypothetical protein PA3033 AlphaFold – – No pocket No Hit N/A —
5469 PA1431 regulatory protein RsaL PA1431, rsaL Experimental + AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0001217A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. +811 total
No pocket No Hit N/A —
5470 PA3632 hypothetical protein PA3632 AlphaFold – – No pocket No Hit N/A —
5471 PA4782 hypothetical protein PA4782 AlphaFold – – No pocket No Hit N/A —
5472 PA3966 hypothetical protein PA3966 AlphaFold – – No pocket No Hit N/A —
5473 PA0975 radical activating enzyme queE, PA0975 AlphaFold
4.3.99.3
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016840Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH4+, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99). GO:0000287Binding to a magnesium (Mg) ion. +47 total
No pocket No Hit N/A —
5474 PA4055 riboflavin synthase subunit alpha ribC, PA4055 AlphaFold
2.5.1.9
GO:0004746Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ = 5-amino-6-(D-ribitylamino)uracil + riboflavin. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
No pocket No Hit N/A —
5475 PA1635 potassium-transporting ATPase subunit C kdpC, PA1635 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008556Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). +36 total
No pocket No Hit N/A —
Page of 223 · 5572 total proteins