Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5476 PA0505 hypothetical protein PA0505 AlphaFold – – No pocket No Hit N/A —
5477 PA4427 ClpXP protease specificity-enhancing factor sspB, PA4427 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0045732Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
No pocket No Hit N/A —
5478 PA3691 hypothetical protein PA3691 AlphaFold – – No pocket No Hit N/A —
5479 PA0914 hypothetical protein PA0914 AlphaFold – – No pocket No Hit N/A —
5480 PA4071 hypothetical protein PA4071 AlphaFold – – No pocket No Hit N/A —
5481 PA3009 hypothetical protein PA3009 AlphaFold – – No pocket No Hit N/A —
5482 PA0579 30S ribosomal protein S21 PA0579, rpsU AlphaFold –
GO:1990904A macromolecular complex that contains both RNA and protein molecules. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +14 total
No pocket No Hit N/A —
5483 PA1747 hypothetical protein PA1747 AlphaFold – – No pocket No Hit N/A —
5484 PA0824 hypothetical protein PA0824 AlphaFold – – No pocket No Hit N/A —
5485 PA0066 hypothetical protein PA0066 AlphaFold – – No pocket Hit 27.3% 5.53e-06
5486 PA0673 hypothetical protein pigB, PA0673 AlphaFold – – No pocket No Hit N/A —
5487 PA1117 hypothetical protein PA1117 AlphaFold – – No pocket No Hit N/A —
5488 PA3524 lactoylglutathione lyase PA3524, gloA1 AlphaFold
4.4.1.5
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004462Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. GO:0046872Binding to a metal ion. +14 total
No pocket Hit 37.8% 2.82e-26
5489 PA2973 peptidase PA2973 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006465OBSOLETE. The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. +25 total
No pocket No Hit N/A —
5490 PA2485 hypothetical protein PA2485 AlphaFold – – No pocket No Hit N/A —
5491 PA0989 hypothetical protein PA0989 AlphaFold – – No pocket No Hit N/A —
5492 PA0721 hypothetical protein PA0721 AlphaFold – – No pocket No Hit N/A —
5493 PA0315 hypothetical protein PA0315 AlphaFold – – No pocket No Hit N/A —
5494 PA2030 hypothetical protein PA2030 AlphaFold – – No pocket No Hit N/A —
5495 PA4005 hypothetical protein rsfS, PA4005 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0043023Binding to a large ribosomal subunit. GO:0042256The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol. +25 total
No pocket Hit 32.8% 3.94e-15
5496 PA2506 hypothetical protein PA2506 AlphaFold – – No pocket No Hit N/A —
5497 PA0568 hypothetical protein PA0568 AlphaFold – – No pocket No Hit N/A —
5498 PA1478 heme exporter protein CcmD ccmD, PA1478 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:1903607The chemical reactions and pathways resulting in the formation of cytochrome c. GO:0017004The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. +25 total
No pocket No Hit N/A —
5499 PA1905 pyridoxamine 5'-phosphate oxidase PA1905, phzG2 AlphaFold –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0004733Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + H2O2. This activity can also oxidize pyridoxine 5'-phosphate to pyridoxal 5'-phosphate + H2O2. GO:0002047The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring. +36 total
No pocket Hit 33.8% 1.93e-26
5500 PA3672 ABC transporter ATP-binding protein PA3672 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No pocket Hit 33.8% 2.99e-31
Page of 223 · 5572 total proteins