Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
901 PA4296 two-component response regulator PprB pprB, PA4296 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. +58 total
0.891 No Hit N/A —
902 PA4047 GTP cyclohydrolase II ribA, PA4047 AlphaFold
3.5.4.25
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005525Binding to GTP, guanosine triphosphate. GO:0003935Catalysis of the reaction: GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H+ + 2 phosphate. +25 total
0.891 No Hit N/A —
903 PA3971 hypothetical protein PA3971 AlphaFold –
GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
0.891 No Hit N/A —
904 PA3659 succinyldiaminopimelate transaminase PA3659 AlphaFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0009016Catalysis of the reaction: N-succinyl-(2S,6S)-2,6-diaminopimelate + 2-oxoglutarate = (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +36 total
0.891 Hit 26.7% 4.58e-08
905 PA3577 hypothetical protein PA3577 AlphaFold – – 0.891 No Hit N/A —
906 PA3465 hypothetical protein PA3465 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. +14 total
0.891 No Hit N/A —
907 PA2858 hypothetical protein PA2858 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.891 No Hit N/A —
908 PA2331 hypothetical protein PA2331 AlphaFold –
GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
0.891 No Hit N/A —
909 PA2018 multidrug efflux protein amrB, PA2018 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +69 total
0.891 No Hit N/A —
910 PA1095 B-type flagellar protein FliS PA1095, fliS AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0044780The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility. GO:0071973Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
0.891 No Hit N/A —
911 PA0422 hypothetical protein PA0422 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +36 total
0.891 No Hit N/A —
912 PA0262 hypothetical protein vgrG2b, PA0262 Experimental + AlphaFold
3.4.24.-
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0033104A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +25 total
0.891 No Hit N/A —
913 PA4637 hypothetical protein PA4637 AlphaFold – – 0.89 No Hit N/A —
914 PA4393 AmpG protein ampG, PA4393 AlphaFold –
GO:0009276The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008521Enables the transfer of acetyl-CoA from one side of a membrane to the other. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. +36 total
0.89 Hit 27.6% 5.63e-07
915 PA4165 transcriptional regulator PA4165 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. +36 total
0.89 Hit 26.9% 4.91e-07
916 PA4017 hypothetical protein PA4017 Experimental + AlphaFold – – 0.89 Hit 30.7% 1.24e-21
917 PA3574a copper chaperone CopZ ColabFold –
GO:0046872Binding to a metal ion.
0.89 No Hit N/A —
918 PA3528 ribonuclease T rnt, PA3528 Experimental + AlphaFold
3.1.13.-
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0000287Binding to a magnesium (Mg) ion. +69 total
0.89 No Hit N/A —
919 PA2199 dehydrogenase PA2199 AlphaFold –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
0.89 Hit 28.0% 1.82e-27
920 PA1686 DNA-3-methyladenine glycosidase II PA1686, alkA AlphaFold
3.2.2.21
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0032131Binding to an alkylated residue in DNA. GO:0008725Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site. +69 total
0.89 No Hit N/A —
921 PA1360 hypothetical protein PA1360 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015565Enables the transfer of threonine from the inside of the cell to the outside of the cell across a membrane. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.89 No Hit N/A —
922 PA1308 hypothetical protein PA1308 AlphaFold – – 0.89 No Hit N/A —
923 PA0475 transcriptional regulator PA0475 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.89 No Hit N/A —
924 PA4948 hypothetical protein PA4948 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. +14 total
0.889 No Hit N/A —
925 PA4443 sulfate adenylyltransferase subunit 2 cysD, PA4443 AlphaFold
2.7.7.4
GO:0009336An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004781Catalysis of the reaction: ATP + H+ + sulfate = adenosine 5'-phosphosulfate + diphosphate. +58 total
0.889 No Hit N/A —
Page of 223 · 5572 total proteins