Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
851 PA0033 hypothetical protein PA0033 AlphaFold –
GO:0004672Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
0.895 No Hit N/A —
852 PA4860 ABC transporter permease PA4860 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015658Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
0.894 No Hit N/A —
853 PA4470 fumarate hydratase fumC1 ColabFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. +36 total
0.894 Hit 44.1% 8.58e-112
854 PA3955 hypothetical protein PA3955 AlphaFold – – 0.894 No Hit N/A —
855 PA3699 transcriptional regulator PA3699 Experimental + AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.894 No Hit N/A —
856 PA3058 pellicle/biofilm biosynthesis Wzx-like polysaccharide transporter PelG PA3058, pelG AlphaFold –
GO:0015774The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
0.894 No Hit N/A —
857 PA2763 hypothetical protein PA2763 AlphaFold – – 0.894 No Hit N/A —
858 PA2481 hypothetical protein PA2481 AlphaFold –
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0046872Binding to a metal ion.
0.894 No Hit N/A —
859 PA2150 non-homologous end joining protein Ku PA2150, ku AlphaFold –
GO:0003690Binding to double-stranded DNA. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0006303The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. +25 total
0.894 No Hit N/A —
860 PA2020 transcriptional regulator PA2020, ttgR, amrR Experimental + AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0001217A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. +58 total
0.894 No Hit N/A —
861 PA1998 transcriptional regulator DhcR PA1998, dhcR AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +25 total
0.894 No Hit N/A —
862 PA1293 hypothetical protein PA1293 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0016844Catalysis of the reaction: 3alpha(S)-strictosidine + H2O = secologanin + tryptamine.
0.894 Hit 37.8% 7.64e-65
863 PA0728 bacteriophage integrase PA0728 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0009009Catalysis of the formation of new phosphodiester bonds between a pair of short, unique target DNA sequences. GO:0007059The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. +25 total
0.894 No Hit N/A —
864 PA0546 S-adenosylmethionine synthetase PA0546, metK AlphaFold
2.5.1.6
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000287Binding to a magnesium (Mg) ion. +36 total
0.894 Hit 56.5% 1.35e-136
865 PA0484 hypothetical protein PA0484 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006351The synthesis of an RNA transcript from a DNA template. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.894 No Hit N/A —
866 PA0097 hypothetical protein PA0097 AlphaFold – – 0.894 No Hit N/A —
867 PA0020 hypothetical protein PA0020 AlphaFold – – 0.894 No Hit N/A —
868 PA5062 hypothetical protein PA5062 AlphaFold – – 0.893 No Hit N/A —
869 PA4284 exodeoxyribonuclease V subunit beta recB, PA4284 AlphaFold
3.1.11.5 5.6.2.4
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0009338An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA. GO:0043138Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis. +1013 total
0.893 No Hit N/A —
870 PA4049 hypothetical protein PA4049 AlphaFold – – 0.893 No Hit N/A —
871 PA3476 acyl-homoserine-lactone synthase PA3476, vsmI, rhlI AlphaFold
2.3.1.184
GO:0061579Catalysis of the reaction: a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + S-methyl-5'-thioadenosine + holo-[ACP] + H+. GO:0120218A quorum sensing process that is modulated by some interaction with a host cell or organism. GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. +14 total
0.893 No Hit N/A —
872 PA3358 hypothetical protein PA3358 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.893 No Hit N/A —
873 PA3345 hypothetical protein PA3345 Experimental + AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009927Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator. GO:0043424Binding to a protein histidine kinase. +47 total
0.893 No Hit N/A —
874 PA3277 short-chain dehydrogenase PA3277 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008202The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
0.893 Hit 43.6% 5.36e-18
875 PA2862 lactonizing lipase PA2862, lip, lipA Experimental + AlphaFold
3.1.1.3
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0016298Catalysis of the hydrolysis of a lipid. GO:0046872Binding to a metal ion. +47 total
0.893 No Hit N/A —
Page of 223 · 5572 total proteins