Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1501 PA3684 hypothetical protein PA3684 AlphaFold – – 0.842 No Hit N/A —
1502 PA3039 transporter PA3039 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008519Enables the energy-independent facilitated diffusion of ammonium through a transmembrane aqueous pore or channel. GO:0097272Any biological process involved in the maintenance of an internal steady state of ammonium. +14 total
0.842 Hit 32.5% 7.63e-08
1503 PA2574 alkane-1 monooxygenase alkB1, PA2574 AlphaFold
1.14.15.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0018685Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O. GO:0046872Binding to a metal ion. +36 total
0.842 No Hit N/A —
1504 PA2329 ABC transporter ATP-binding protein PA2329 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.842 Hit 34.6% 1.32e-17
1505 PA2220 transcriptional regulator PA2220 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template. +14 total
0.842 No Hit N/A —
1506 PA2039 hypothetical protein PA2039 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:1903785The directed movement of L-valine across a membrane.
0.842 No Hit N/A —
1507 PA1648 oxidoreductase PA1648 Experimental + AlphaFold –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0016628Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.842 Hit 41.2% 1.11e-50
1508 PA1634 potassium-transporting ATPase subunit B kdpB, PA1634 AlphaFold
7.2.2.6
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0031004Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex. GO:1903103A protein complex which is capable of potassium:proton antiporter activity. +912 total
0.842 Hit 35.1% 2.12e-10
1509 PA1489 hypothetical protein PA1489 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.842 Hit 24.3% 1.85e-12
1510 PA1226 transcriptional regulator PA1226 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.842 No Hit N/A —
1511 PA0730 (R)-3-hydroxydecanoyl-ACP:CoA transacylase phaG, PA0730, qin AlphaFold
2.4.1.-
GO:0090499Catalysis of the reaction: 6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + H+ + methanol. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.
0.842 No Hit N/A —
1512 PA0477 transcriptional regulator PA0477 Experimental + AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.842 No Hit N/A —
1513 PA5562 chromosome partitioning protein PA5562, spoOJ AlphaFold –
GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0042802Binding to an identical protein or proteins. +25 total
0.841 No Hit N/A —
1514 PA4051 thiamine monophosphate kinase thiL, PA4051 Experimental + AlphaFold
2.7.4.16
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000287Binding to a magnesium (Mg) ion. GO:0009030Catalysis of the reaction: ATP + thiamine phosphate = ADP + H+ + thiamine diphosphate. +25 total
0.841 No Hit N/A —
1515 PA3217 protein CyaB cyaB, PA3217 Experimental + AlphaFold –
GO:0004016Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. GO:0006171The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). GO:0035556The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. +14 total
0.841 Hit 29.9% 8.10e-12
1516 PA1825 hypothetical protein PA1825 AlphaFold – – 0.841 No Hit N/A —
1517 PA1535 acyl-CoA dehydrogenase PA1535 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003995Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. GO:0034824Catalysis of the reaction: citronellyl-CoA + NAD+ = cis-geranyl-CoA + NADH + H+. +47 total
0.841 Hit 42.2% 1.38e-25
1518 PA1005 hypothetical protein PA1005 AlphaFold
3.4.-.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. +69 total
0.841 No Hit N/A —
1519 PA0711 hypothetical protein PA0711 AlphaFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.841 No Hit N/A —
1520 PA5498 adhesin PA5498 AlphaFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0000006Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. GO:0008270Binding to a zinc ion (Zn). +47 total
0.84 No Hit N/A —
1521 PA5417 sarcosine oxidase subunit delta soxD, PA5417 AlphaFold –
GO:0008115Catalysis of the reaction: H2O + O2 + sarcosine = formaldehyde + glycine + H2O2. GO:1901053OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sarcosine. GO:0046653The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
0.84 No Hit N/A —
1522 PA4360a hypothetical protein ColabFold – – 0.84 No Hit N/A —
1523 PA4027a hypothetical protein ColabFold – – 0.84 No Hit N/A —
1524 PA3369 hypothetical protein PA3369 AlphaFold – – 0.84 No Hit N/A —
1525 PA3288 hypothetical protein PA3288 AlphaFold – – 0.84 No Hit N/A —
Page of 223 · 5572 total proteins