Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1551 PA2956 hypothetical protein PA2956 AlphaFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0046872Binding to a metal ion.
0.838 No Hit N/A —
1552 PA2943 phospho-2-dehydro-3-deoxyheptonate aldolase PA2943 AlphaFold
2.5.1.54
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003849Catalysis of the reaction: D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. GO:0042802Binding to an identical protein or proteins. +47 total
0.838 No Hit N/A —
1553 PA2781 hypothetical protein PA2781 AlphaFold – – 0.838 No Hit N/A —
1554 PA2469 transcriptional regulator PA2469 AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.838 No Hit N/A —
1555 PA1130 rhamnosyltransferase rhlC, PA1130 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016758Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. +25 total
0.838 No Hit N/A —
1556 PA0961 cold-shock protein ColabFold –
GO:0003676Binding to a nucleic acid.
0.838 Hit 66.7% 4.99e-06
1557 PA0917 potassium transport system protein kup PA0917, kup AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015079Enables the transfer of potassium ions (K+) from one side of a membrane to the other. +36 total
0.838 No Hit N/A —
1558 PA0503 biotin synthesis protein BioC PA0503, bioC AlphaFold
2.1.1.197
GO:0010340Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester. GO:0102130Catalysis of the reaction: S-adenosyl-L-methionine + a malonyl-[acp] = S-adenosyl-L-homocysteine + a malonyl-[acp] methyl ester. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +36 total
0.838 Hit 31.0% 4.70e-16
1559 PA0274 hypothetical protein PA0274 AlphaFold – – 0.838 No Hit N/A —
1560 PA4861 ABC transporter ATP-binding protein PA4861 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.837 Hit 30.0% 2.09e-12
1561 PA4648 hypothetical protein PA4648 AlphaFold – – 0.837 No Hit N/A —
1562 PA4425 phosphoheptose isomerase gmhA, PA4425 Experimental + AlphaFold
5.3.1.28
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990102A protein-DNA complex containing a tetramer of DiaA attached to multiple DnaA molecule bound to oriC DNA. Regulates timely initiation of chromosomal replication during the cell cycle by stimulating assembly of DnaA-oriC complexes, conformational changes in ATP-DnaA initiation complexes, and unwinding of oriC duplex DNA. GO:0097367Binding to a carbohydrate derivative. +69 total
0.837 No Hit N/A —
1563 PA4092 4-hydroxyphenylacetate 3-monooxygenase small subunit hpaC, PA4092 AlphaFold
1.5.1.37
GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0036382Catalysis of the reaction: a reduced flavin + NAD+ = an oxidized flavin + 2 H+ + NADH. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +58 total
0.837 No Hit N/A —
1564 PA3778 transcriptional regulator PA3778 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.837 No Hit N/A —
1565 PA3560 PTS system fructose-specific transporter subunit IIBC fruA, PA3560 AlphaFold
2.7.1.202
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005351Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +58 total
0.837 No Hit N/A —
1566 PA3539 hypothetical protein PA3539 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0033194Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
0.837 No Hit N/A —
1567 PA3132 hydrolase PA3132 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.837 No Hit N/A —
1568 PA2821 glutathione S-transferase PA2821 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0043295Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine. GO:0004364Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+.
0.837 Hit 32.9% 2.16e-09
1569 PA2682 hypothetical protein PA2682 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.837 Hit 27.6% 1.14e-10
1570 PA2654 chemotaxis transducer PA2654, tlpQ Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. +14 total
0.837 No Hit N/A —
1571 PA1760 transcriptional regulator PA1760 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +25 total
0.837 No Hit N/A —
1572 PA5121 hypothetical protein PA5121 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008381Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
0.836 No Hit N/A —
1573 PA5029 transcriptional regulator PA5029 AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.836 No Hit N/A —
1574 PA4389 3-ketoacyl-ACP reductase speA, PA4389 AlphaFold
1.3.1.58
GO:0018511Catalysis of the reaction: cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+ = 2,3-dihydroxy-p-cumate + H+ + NADH. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0030497The elongation of a fatty acid chain by the sequential addition of two-carbon units.
0.836 Hit 41.8% 9.96e-52
1575 PA3233 hypothetical protein PA3233 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008773Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII). GO:0015095Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other.
0.836 No Hit N/A —
Page of 223 · 5572 total proteins